| Source: HalifaxProj(inhibit) |
| Type: |
| Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts. IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth. IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin. |
| 7917- | IVT, | A review on the pharmacological effects of vitexin and isovitexin |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7890- | IVT, | Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses |
| - | in-vivo, | Nor, | NA |
| 7904- | IVT, | Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress |
| - | in-vivo, | Nor, | NA |
| 5119- | JG, | Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice |
| - | in-vivo, | Nor, | NA |
| 4007- | K+, | The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 8104- | KAE, | A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation |
| - | Review, | Nor, | NA |
| 8105- | KAE, | Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review |
| - | Review, | Var, | NA |
| 8080- | KAE, | Hepatoprotective Effect of Kaempferol—A Review |
| - | Review, | Nor, | NA |
| 8154- | lamb, | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells |
| - | in-vitro, | Nor, | NA |
| 8151- | lamb, | Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | BC, | MDA-MB-231 |
| 8156- | lamb, | A review on chemistry, source and therapeutic potential of lambertianic acid |
| - | Review, | Var, | NA |
| 8157- | lamb, | Pinus koraiensis leaf extract and lambertianic acid attenuate fatigue and improve endurance capacity via PI3K-mediated regulation of oxidative stress and mitochondrial biogenesis |
| - | in-vivo, | Nor, | NA |
| 8221- | LCA, | Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects |
| - | in-vitro, | Nor, | NA |
| 8229- | LCA, | Licochalcone A: a review of its pharmacology activities and molecular mechanisms |
| - | Review, | Nor, | NA |
| 8236- | LE, | Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects |
| - | Review, | Var, | NA |
| 8145- | LF, | Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 8135- | LF, | Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 8144- | LF, | A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway |
| - | Human, | AD, | NA |
| 6482- | LIN, | Pharmacological and molecular insights into linalool-rich Coriandrum sativum essential oil: Anticonvulsant, analgesic, anti-inflammatory, and antioxidant potential in rodent models |
| - | Review, | Nor, | NA |
| 4292- | LT, | Luteolin for neurodegenerative diseases: a review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | MS, | NA | - | Review, | Stroke, | NA |
| 2921- | LT, | Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies |
| - | Review, | Nor, | NA |
| 2911- | LT, | Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes |
| - | in-vitro, | Nor, | HaCaT |
| 2919- | LT, | Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence |
| - | Review, | Var, | NA |
| 2916- | LT, | Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3531- | Lyco, | Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system |
| - | in-vivo, | Nor, | NA |
| 3528- | Lyco, | The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3264- | Lyco, | Pharmacological potentials of lycopene against aging and aging‐related disorders: A review |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 3277- | Lyco, | Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent |
| - | Review, | Var, | NA |
| 3278- | Lyco, | Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells |
| - | in-vitro, | Colon, | SW480 |
| 1708- | Lyco, | The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies |
| - | Review, | Var, | NA |
| 4780- | Lyco, | Potential inhibitory effect of lycopene on prostate cancer |
| - | Review, | Pca, | NA |
| 4781- | Lyco, | 5-FU, | Chemo, | Cisplatin, | Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells |
| - | in-vitro, | Colon, | Caco-2 |
| 4782- | Lyco, | New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene |
| - | Review, | Var, | NA |
| 4784- | Lyco, | Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives |
| - | Review, | Diabetic, | NA | - | Review, | CardioV, | NA |
| 4801- | Lyco, | Lycopene in the Prevention of Cardiovascular Diseases |
| - | Review, | CardioV, | NA |
| 1782- | MEL, | Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities |
| - | Review, | Var, | NA |
| 1779- | MEL, | Therapeutic Potential of Melatonin Counteracting Chemotherapy-Induced Toxicity in Breast Cancer Patients: A Systematic Review |
| - | Review, | BC, | NA |
| 2246- | MF, | The Use of Pulsed Electromagnetic Field to Modulate Inflammation and Improve Tissue Regeneration: A Review |
| - | in-vitro, | Nor, | NA |
| 3741- | MF, | Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders |
| - | Review, | NA, | NA |
| 3536- | MF, | Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis |
| - | Review, | Arthritis, | NA | - | Review, | Stroke, | NA |
| 3474- | MF, | Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration |
| - | in-vitro, | Nor, | NA |
| 3470- | MF, | Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8+ T cell dysfunction and suppress cervical cancer progression |
| - | in-vitro, | Cerv, | HeLa |
| 3468- | MF, | An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing |
| - | Review, | NA, | NA |
| 221- | MFrot, | MF, | Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma |
| - | in-vivo, | Liver, | NA |
| 204- | MFrot, | MF, | Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization |
| - | in-vivo, | AD, | NA |
| 198- | MFrot, | MF, | Biological effects of rotating magnetic field: A review from 1969 to 2021 |
| - | Review, | Var, | NA |
| 3847- | MSM, | Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement |
| - | Review, | Arthritis, | NA |
| 1806- | NarG, | Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications |
| - | Review, | NA, | NA |
| 5253- | NCL, | Niclosamide: Beyond an antihelminthic drug |
| - | Review, | Var, | NA |
| 6489- | Nimb, | Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model |
| - | in-vivo, | Pca, | DU145 | - | in-vivo, | Pca, | LNCaP |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:158 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid