lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
2110- TQ,    Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HEK293
P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,
3400- TQ,  Chemo,    Thymoquinone Ameliorates Carfilzomib-Induced Renal Impairment by Modulating Oxidative Stress Markers, Inflammatory/Apoptotic Mediators, and Augmenting Nrf2 in Rats
- in-vitro, Nor, NA
*GSH↑, *SOD↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *Casp3↓, *Catalase↑, *NRF2↑, *RenoP↑,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3571- TQ,    The Role of Thymoquinone in Inflammatory Response in Chronic Diseases
- Review, Var, NA - Review, Stroke, NA
*BioAv↓, *BioAv↑, *Inflam↓, *antiOx↑, *ROS↓, *GSH↑, *GSTs↑, *MPO↓, *NF-kB↓, *COX2↓, *IL1β↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *cardioP↑, *lipid-P↓, *TAC↑, *RenoP↑, Apoptosis↑, TumCCA↑, TumCP↓, TumCMig↓, angioG↓, TNF-α↓, NF-kB↓, ROS↑, EMT↓, *Aβ↓, *p‑tau↓, *BACE↓, *TLR2↓, *TLR4↓, *MyD88↓, *IRF3↓, *eff↑, eff↑, DNAdam↑, *iNOS↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4874- Uro,  EGCG,    A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease
- in-vivo, AD, NA
*motorD↑, *memory↑, *MitoP↑, *Aβ↓, *mitResp↑, *Nrf1↑, *PINK1↑, *PARK2↑, *ATG5↑, *Bcl-2↑, *H2O2↓, *ROS↓, *lipid-P↓, *mt-ATP↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4858- Uro,    The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent
- in-vitro, Nor, NA
*ROS?, *neuroP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *monoA↓, *tyrosinase↓,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
4468- VitC,  SSE,    Selenium modulates cancer cell response to pharmacologic ascorbate
- in-vivo, GBM, U87MG - in-vitro, CRC, HCT116
eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, NA, NA
RNR↓, GSH↓, Trx1↓, GPx↓, lipid-P↑, AIF↑, ROS↑,
4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *cardioP↑, *lipid-P↓, *cognitive↑, *neuroP↑, *Aβ↓, *NGF↑,
1221- Z,    Unexpected zinc dependency of ferroptosis: what is in a name?
- Analysis, Nor, NA
*Ferroptosis↑, *ROS↑, *lipid-P↑,

Showing Research Papers: 251 to 268 of 268
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 268

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   GPx↓, 1,   GSH↓, 2,   H2O2↑, 2,   lipid-P↑, 4,   ROS↑, 3,   ROS⇅, 1,   i-ROS↑, 1,   Trx1↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

cMyc↑, 1,   FASN↓, 1,   Glycolysis↓, 1,   NAD↓, 1,   RNR↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 4,   BAX↑, 4,   Bcl-2↓, 3,   Casp↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   p38↑, 1,   survivin↓, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,   tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↝, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   FOXO1↑, 1,   PI3K↓, 2,   TumCG↓, 3,  

Migration ⓘ

Ca+2↑, 2,   MMP2↓, 1,   MMP9↓, 1,   PKCδ↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Imm↑, 1,   NF-kB↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   eff↓, 3,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 2,   hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 74

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 6,   Catalase↑, 8,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GPx↑, 8,   GSH↑, 6,   GSR↑, 4,   GSTs↑, 2,   H2O2↓, 3,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 13,   lipid-P↑, 1,   MDA↓, 3,   MPO↓, 1,   NADH↓, 1,   Nrf1↑, 1,   NRF2↑, 5,   PARK2↑, 2,   RNS↓, 1,   ROS?, 1,   ROS↓, 12,   ROS↑, 1,   SIRT3↑, 1,   SOD↑, 10,   TAC↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mt-ATP↑, 1,   mitResp↑, 1,   MMP↑, 3,   PINK1↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   ALAT↓, 1,   AMPK↑, 1,   BUN↓, 1,   cMyc↓, 1,   CREB↑, 1,   LDH↓, 2,   LDL↓, 2,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↓, 1,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Casp3↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   PI3K↓, 1,   tyrosinase↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Cartilage↑, 1,   MMP9↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 2,   BBB↝, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 3,   CRP↓, 2,   IFN-γ↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 5,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 9,   MyD88↓, 2,   NF-kB↓, 4,   TLR1↓, 1,   TLR2↓, 2,   TLR4↓, 2,   TNF-α↓, 4,   TRIF↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,   monoA↓, 1,   NGF↑, 1,   tau↓, 1,   p‑tau↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 7,   BACE↓, 1,   NLRP3↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 1,   eff↑, 4,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 1,   CRP↓, 2,   GutMicro↑, 1,   IL6↓, 5,   LDH↓, 2,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 5,   cognitive↑, 6,   hepatoP↑, 1,   memory↑, 4,   motorD↑, 2,   neuroP↑, 8,   Obesity↓, 1,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 2,   Strength↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   IRF3↓, 2,  
Total Targets: 135

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
14 Thymoquinone
12 Quercetin
12 Silymarin (Milk Thistle) silibinin
11 Curcumin
10 Silver-NanoParticles
10 Alpha-Lipoic-Acid
10 Resveratrol
7 Artemisinin
7 Rosmarinic acid
6 Ashwagandha(Withaferin A)
6 Berberine
6 Carvacrol
6 Lycopene
6 Shikonin
6 Urolithin
5 Luteolin
5 Chrysin
5 Ferulic acid
5 Piperlongumine
5 Selenium NanoParticles
5 Selenite (Sodium)
4 Vitamin C (Ascorbic Acid)
4 Bacopa monnieri
4 Boron
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Chemotherapy
4 Copper and Cu NanoParticles
3 Allicin (mainly Garlic)
3 chitosan
3 Cinnamon
3 Coenzyme Q10
3 Selenium
3 Crocetin
3 erastin
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Juglone
3 Moringa oleifera
3 Phenethyl isothiocyanate
3 Pterostilbene
3 salinomycin
2 alpha Linolenic acid
2 Astaxanthin
2 Baicalein
2 Biochanin A
2 beta-carotene(VitA)
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carnosine
2 Citric Acid
2 Vitamin E
2 Disulfiram
2 EGCG (Epigallocatechin Gallate)
2 Fisetin
2 Graviola
2 Hydrogen Gas
2 Piperine
2 Rutin
2 Radiotherapy/Radiation
1 Astragalus
1 Glucose
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Aloe anthraquinones
1 Betulinic acid
1 Bromelain
1 Bruteridin(bergamot juice)
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 Hydroxycinnamic-acid
1 Honokiol
1 HydroxyTyrosol
1 Melatonin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phosphatidylserine
1 Sulfasalazine
1 Sulforaphane (mainly Broccoli)
1 Shankhpushpi
1 Spermidine
1 Taurine
1 5-fluorouracil
1 Vitamin B5,Pantothenic Acid
1 VitK3,menadione
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:453  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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