Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE/β-secretase↓,
4327- VitB1/Thiamine,    Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease
- Study, AD, NA
*Risk↓, *other↝,
4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, *cognitive↑, *cognitive∅,
4324- VitB5,    Substantively Lowered Levels of Pantothenic Acid (Vitamin B5) in Several Regions of the Human Brain in Parkinson’s Disease Dementia
- Study, AD, NA - Study, Park, NA
*Risk↓, *other↝, *other↝, *Ach↑, *Aβ↑, *other?,
4326- VitB5,    Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
- in-vivo, HD, NA
*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,
4325- VitB5,    Localized Pantothenic Acid (Vitamin B5) Reductions Present Throughout the Dementia with Lewy Bodies Brain
- Study, AD, NA - Study, Park, NA
*Risk↑, *Dose↝, *Dose↓, *other↝,
4323- VitB5,    Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease
- Study, AD, NA
*Risk↓, *Acetyl-CoA↑, *Ach↑, *neuroP↑,
4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, *other↑, *other↑, *cognitive↑, *eff↝, *Risk↑, *other↑,
4055- VitB6,  VitD3,    Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patients
- Study, AD, NA
*Risk↓, *cognitive↑,
4057- VitB6,  VitB12,  FA,    Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Study, AD, NA
*Risk↓, *Risk∅,
4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, *Risk↓, *Risk↓, *cognitive↑,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *Hcy/homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,
4319- VitC,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *Inflam↓, *Risk↓, *cognitive↑,
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
4350- VitD3,    Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
- Review, Var, NA - Review, AD, NA
Risk↓, angioG↓, TumMeta↓, AntiCan↑, *cognitive↑, *Mood↑,
4320- VitD3,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Calcium↝, *cognitive↑, *Aβ↓, *Inflam↓, *Risk↓, *other↝,
4618- VitD3,    Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1
- in-vivo, Cerv, NA
Risk↓, RadioS↑, Apoptosis↑, EMT↝,
1739- VitD3,    Effect of Vitamin D3 Supplements on Development of Advanced Cancer
- Trial, Var, NA
AntiCan↑, Dose↝, Risk↓, TumCP↓, Inflam↓, eff∅,
1740- VitD3,    Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms
- Review, Var, NA
Risk↓, eff↑, eff↑, Risk↓, Risk↓, ChemoSen↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp9↑, hTERT/TERT↓, eff↑, E-cadherin↑, CLDN2↑, ZO-1↑, Snail↓, Zeb1↓, Vim↓, VEGF↓, NK cell↑, Risk↓, eff↑,
7068- VitD3,    Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer’s Disease
- in-vivo, AD, NA
*Aβ↓, *GABA↓, Risk↓,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,
2285- VitK2,    New insights into vitamin K biology with relevance to cancer
- Review, Var, NA
Risk↓, AntiCan↑, eff↑, MMP↓, ROS↑, Cyt‑c↑, eff↓, SXR↑,
4309- VitK2,    Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Review, NA, NA
*Apoptosis↓, *ROS↓, *antiOx↑, *cognitive↑, *memory↑, *Risk↓, *p‑tau↓,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1818- VitK2,    New insights on vitamin K biology with relevance to cancer
- Review, Var, NA
TumCG↓, ChemoSen↑, toxicity∅, OS↑, BMD↑, eff↑, MMP↓, ROS↑, eff↓, ERK↑, JNK↑, p38↑, Cyt‑c↑, Casp↑, ATP↓, lactateProd↑, AMPK↑, Rho↓, TumCG↓, BioAv↑, cardioP↑, Risk↓,
1825- VitK2,    Vitamin K intake and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial
- Analysis, Pca, NA
Risk∅,
1830- VitK2,    Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study
- Study, Lung, NA
Risk↓, NF-kB↓, PKCδ↓,
1759- WBV,    Prostate cancer and occupational exposure to whole-body vibration in a national population-based cohort study
- Study, Pca, NA
Risk↓,

Showing Research Papers: 251 to 280 of 280
Prev Page 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 280

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   Glycolysis↓, 1,   lactateProd↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Casp↑, 1,   Casp3↑, 1,   pro‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 4,   Fas↑, 1,   FasL↑, 1,   hTERT/TERT↓, 1,   JNK↑, 2,   p38↑, 1,   YAP/TEAD↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,   IRE1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↝, 1,   ERK↑, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

CLDN2↑, 1,   E-cadherin↑, 1,   MMPs↓, 1,   PKCδ↓, 1,   Rho↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCP↓, 1,   TumMeta↓, 2,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   NK cell↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

SXR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 1,   eff↓, 2,   eff↑, 9,   eff∅, 1,   RadioS↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   hTERT/TERT↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   cardioP↑, 1,   OS↑, 1,   Risk↓, 14,   Risk∅, 1,   toxicity∅, 2,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   PARK2↑, 1,   ROS↓, 6,   SIRT3↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↑, 1,   AMPK↑, 1,   GlucoseCon↑, 1,   LDL↓, 1,   NADPH↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 3,   other?, 2,   other↑, 3,   other↝, 8,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,   Inflam↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↓, 1,   MAOA↓, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   Aβ↑, 1,   BACE/β-secretase↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↓, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 1,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Calcium↝, 1,   GutMicro↑, 2,   Hcy/homoC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 11,   cognitive∅, 1,   memory↑, 1,   Mood↑, 1,   neuroP↑, 6,   Risk↓, 20,   Risk↑, 3,   Risk∅, 2,   Strength↑, 1,   toxicity↓, 1,  
Total Targets: 62

Scientific Paper Hit Count for: Risk, Risk
23 Selenium
18 Folic Acid, Vit B9
16 Boron
15 Selenite (Sodium)
13 Aspirin
10 Vitamin D3
10 Lycopene
9 Choline
8 Vitamin B6,pyridoxine
7 Vitamin K2
7 Magnesium
6 Allicin (mainly Garlic)
6 Vitamin C (Ascorbic Acid)
6 diet Plant based
6 Exercise
6 Vitamin B12
6 Kaempferol
6 Phenethyl isothiocyanate
5 Chemotherapy
5 Hormone replacement therapy
5 Calcium
5 diet Fermented Foods
5 isoflavones
5 Selenium NanoParticles
4 beta-carotene(VitA)
4 Capsaicin
4 Coenzyme Q10
4 Vitamin E
4 Sulforaphane (mainly Broccoli)
4 Vitamin B5,Pantothenic Acid
3 Aluminum
3 Radiotherapy/Radiation
3 Celecoxib
3 Chlorogenic acid
3 Chocolate
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Silicic Acid
3 iodine
3 Melatonin
3 Metformin
3 Urolithin
2 5-Hydroxytryptophan
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Bruteridin(bergamot juice)
2 Butyrate
2 EGCG (Epigallocatechin Gallate)
2 flavonoids
2 Indole-3-carbinol
2 Inulin Prebiotic
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Potassium
2 Lutein
2 Zeaxanthin
2 Quercetin
2 chitosan
2 Taurine
2 Vitamin B1/Thiamine
1 Anthocyanins
1 alpha Linolenic acid
1 Astaxanthin
1 beta-glucans
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Bullatacin
1 Carvacrol
1 Catechins
1 Chyawanprash
1 Dipyridamole
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Vitamin A, Retinoic Acid
1 Fisetin
1 Fucoidan
1 Ginkgo biloba
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Graviola
1 Grapeseed extract
1 Inositol
1 isoquercitrin
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 Oleuropein
1 Rutin
1 buckwheat sprouts
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:785  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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