Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
6290- DL,    Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells
- in-vitro, AML, K562 - in-vitro, AML, HL-60
BAX↑, Cyt‑c↑, Casp9↑, cl‑Casp3↑, mtDam↑, Apoptosis↑,
6265- DL,    Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee
- Trial, Var, NA
toxicity↓, Dose↑, OS↑,
6266- DL,    Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓, IGF-1↑, TumCCA↑, TumCP↓,
6267- DL,    Effect of d-limonene and its derivatives on breast cancer in human trials: a scoping review and narrative synthesis
- Review, BC, NA
*toxicity↓, cycD1/CCND1↓, TumCP↓, other↑,
6268- DL,    Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2)
- in-vitro, Liver, HepG2
other↑,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6270- DL,    d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
- vitro+vivo, Lung, A549 - vitro+vivo, Lung, H1299
TumCG↓, Apoptosis↑, TumAuto↑, Dose?,
6271- DL,    D-limonene rich volatile oil from blood oranges inhibits angiogenesis, metastasis and cell death in human colon cancer cells
- in-vitro, Colon, SW480 - in-vitro, Colon, HT-29
TumCP↓, Apoptosis↑, Bax:Bcl2↑, VEGF↓, angioG↓, TumMeta↓, VEGFR1↓, MMP9↓,
6272- DL,    Anti‐leukemic and anti‐angiogenic effects of d‐Limonene on K562‐implanted C57BL/6 mice and the chick chorioallantoic membrane model
- vitro+vivo, CLL, NA
angioG↓, other↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6275- DL,    Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans
- in-vivo, Col, NA
*TNF-α↓, *Inflam↓, *IL6↓,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6287- DL,    D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis
- in-vivo, Covid, NA
*PI3K↓, *Akt↓, *NF-kB↓,
6286- DL,    d-Limonene inhibits cytokines and chemokines expression by regulating NF-kappaB and STAT in HaCat cells and DNCB-induced atopic dermatitis in BALB/c mice
- in-vitro, Nor, NA
*Inflam↓,
6285- DL,    Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
VEGF↓, *STAT3↓, TumCP↓, TumMeta↓, p‑STAT3↓, MMP9↓, SHP1↑, angioG↓,
6284- DL,    Chemoprevention and therapy of cancer by d-limonene
- in-vivo, Var, NA
chemoPv↑, other↑,
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6279- DL,    Human breast tissue disposition and bioactivity of limonene in women with early stage breast cancer
- Trial, BC, NA
chemoPv↑, cycD1/CCND1↓,
6276- DL,  Tam,    Combination of tamoxifen and D-limonene enhances therapeutic efficacy in breast cancer cells
- in-vitro, BC, MCF7
TumCG↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, Apoptosis↑,
6283- DL,    D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
- in-vivo, Nor, NA
*TGF-β1↓, *VEGF↓, *MDA↓, *GPx↑, *Catalase↑, *Inflam↓, *ROS↓, *angioG↓,
6728- DMSO,    Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes
- in-vitro, Nor, NA
*CellMemb↑, *CryoP↑,
6727- DMSO,    The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics

6726- DMSO,    DMSO induces apoptosis in SV40-transformed human keratinocytes, but not in normal keratinocytes
- in-vitro, NA, NA
Apoptosis↑, selectivity↑,
6725- DMSO,    DMSO induces dehydration near lipid membrane surfaces
- Study, Nor, NA
*CellMemb↑, *CryoP↑,
6724- DMSO,    Ion transport through dimethyl sulfoxide (DMSO) induced transient water pores in cell membranes
- in-vitro, Nor, NA
*CellMemb↑, *Ca+2↑,
6723- DMSO,    Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide
- Review, Nor, NA
*BioEnh↑, *other↝,
5386- docx,  AsP,    Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy
- vitro+vivo, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Pca, PC3
Dose↝, ROS↑, eff↑, eff↑,
6328- DRE,    Hydroalcoholic extract of Taraxacum officinale induces apoptosis and autophagy in 4T1 breast cancer cells
- in-vitro, BC, 4T1
TumCG↓, TumCP↓, Apoptosis↑, TumAuto↑, DNAdam↑, BAX↑, Bax:Bcl2↑, P53↑, Beclin-1/ATG6↑, ATG7↑, Bcl-2↓, NO↓,
6329- DRE,  VitA,RetA,    Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MMP9↓, IL1β↓, P53↑, KAI1/CD82↑, eff↑,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6344- DRE,    Dandelion: Purported Benefits, Side Effects & More
- Review, Var, NA
*other↝, *hepatoP↑, *ALAT↓, *MDA↓, *TNF-α↓, *IL6↓, *antiOx↑, *Inflam↓, *proCasp3↓, Casp3↑, tumCV↓, TNF-α↑, IL1↑,
6345- DRE,    Human clinical trials on for cancer killing dandelion extract
- Review, AML, NA
TumCD↑,
6346- DRE,    Unusual Response of Acute Monocytic Leukemia to Dandelion Root Extract
- Case Report, AML, NA
QoL↑, other↑, Dose↝,
6347- DRE,    Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure
*hepatoP↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓, *creat↓, *TOS↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6349- DRE,    Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
- vitro+vivo, Nor, NCM460
*Apoptosis↓, *ROS↓, *NF-kB↓, *other↓,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6326- DRE,  MT/VAE,    Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy
- in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, Apoptosis↑, MMP↓, TumCI↓, TumCMig↓, eff↑,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6321- DRE,    Dandelion root extract suppressed gastric cancer cells proliferation and migration through targeting lncRNA-CCAT1
- in-vitro, GC, NA
CCAT1↓, TumCP↓, TumCMig↓,
6322- DRE,  LGE,    Dandelion Root and Lemongrass Extracts Induce Apoptosis, Enhance Chemotherapeutic Efficacy, and Reduce Tumour Xenograft Growth In Vivo in Prostate Cancer
- vitro+vivo, Pca, DU145
AntiCan↑, ChemoSen↑, Dose↝, *ROS↓, Apoptosis↑, selectivity↑, *toxicity↓, *chemoP↑, eff↓, ROS↑,
6327- DRE,    Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, CRC, HCT116 - in-vitro, Nor, Hs27
TumCG↓, selectivity↑, p‑AMPK↑,

Showing Research Papers: 3201 to 3250 of 8269
Prev Page 65 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

KAI1/CD82↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GSH↓, 2,   OXPHOS↓, 1,   ROS↑, 7,   mt-ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   MMP↓, 5,   mtDam↑, 3,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑AMPK↑, 1,   ATG7↑, 1,   FABP4↓, 1,   Glycolysis↓, 1,   LDH↑, 1,   PPARγ↑, 1,   SCD1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 16,   BAD↑, 1,   BAX↑, 8,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 1,   BID↑, 1,   cl‑BID↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 3,   Casp8↓, 1,   Casp8↑, 4,   Casp9↑, 5,   cl‑Casp9↑, 1,   Cyt‑c↑, 4,   iNOS↓, 1,   JNK↓, 1,   MOMP↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 5,   tumCV↓, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↓, 1,   P53↑, 4,   PARP↓, 1,   cl‑PARP↑, 2,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   P21↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   Diff↑, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   IGF-1↑, 1,   mTOR↓, 1,   PI3K↓, 4,   RAS↓, 1,   SHP1↑, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   STAT6↓, 1,   TumCG↓, 7,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

CCAT1↓, 1,   p‑FAK↓, 1,   Ki-67↓, 1,   MMP2↓, 4,   MMP9↓, 7,   PAK1↓, 1,   TGF-β↑, 1,   TumCI↓, 4,   TumCMig↓, 7,   TumCP↓, 11,   TumMeta↓, 2,   VEGFR1↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   NO↓, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   IL1↑, 1,   IL1β↓, 1,   IL1β↑, 1,   JAK1↓, 1,   NF-kB↑, 1,   TNF-α↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 3,   DDS↑, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 5,   eff↓, 2,   eff↑, 9,   selectivity↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   chemoPv↑, 4,   OS↑, 1,   QoL↑, 1,   toxicity↓, 3,  
Total Targets: 114

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CryoP↑, 2,   diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Bil↓, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 2,   lipid-P↓, 1,   MDA↓, 2,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 10,   SOD↑, 2,   TOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   Bax:Bcl2↑, 1,   Casp1↓, 1,   Casp3↓, 1,   proCasp3↓, 1,   Casp9↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   TGF-β1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 3,   GastroP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 2,   Inflam↓, 11,   NF-kB↓, 4,   TLR4↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioEnh↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 1,   Bil↓, 1,   creat↓, 2,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 4,   chemoP↑, 1,   hepatoP↑, 4,   neuroP↑, 3,   Obesity↓, 1,   RenoP↑, 1,   toxicity?, 1,   toxicity↓, 6,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 70

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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