Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1619- EA,  CUR,    Antimutagenic Effect of the Ellagic Acid and Curcumin Combinations
- in-vitro, Nor, NA
eff↑,
1617- EA,  CUR,    The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
- in-vitro, Nor, NA
Dose∅, GSTs↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1610- EA,    Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer
- Review, Cerv, NA
TumCCA↑, STAT3↓, P21↑, IGFBP7↑, Akt↓, mTOR↓, ROS↑, DNAdam↑, P53↑, P21↑, BAX↑,
1611- EA,    Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues
- in-vitro, Mal, NA
*BioAv↓, eff↑, *BioAv↓, ROS↑,
1612- EA,    Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cell
- in-vitro, EC, NA
NHE1↓, i-pH↓, ROS↓, GlucoseCon↓, NHE1↓, Glycolysis↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
1614- EA,    Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
- Human, Nor, NA
*BioEnh↝, *Half-Life∅,
1615- EA,    Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
- Human, Nor, NA
*BioAv∅, *ROS∅,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
3756- EA,    Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
- Analysis, AD, NA
*AChE↓, *BACE/β-secretase↓, *MAOB↓,
1110- EA,  GEM,    Ellagic Acid Resensitizes Gemcitabine-Resistant Bladder Cancer Cells by Inhibiting Epithelial-Mesenchymal Transition and Gemcitabine Transporters
- vitro+vivo, Bladder, NA
TGF-β↓, SMAD2↓, SMAD3↓, SMAD4↓,
1037- EA,    Unripe Black Raspberry (Rubus coreanus Miquel) Extract and Its Constitute, Ellagic Acid Induces T Cell Activation and Antitumor Immunity by Blocking PD-1/PD-L1 Interaction
- in-vivo, CRC, NA
AntiTum↑, PD-L1↓,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
6769- Ech,    Echinacea
- Review, Nor, NA
*Imm↑,
6616- Ech,    Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated
- in-vivo, Nor, NA
*NK cell↑, *Imm↑,
6611- Ech,    Proliferative activity of a blend of Echinacea angustifolia and Echinacea purpurea root extracts in human vein epithelial, HeLa, and QBC-939 cell lines, but not in Beas-2b cell lines
- in-vitro, Cerv, HeLa - in-vitro, Nor, BEAS-2B - in-vitro, Nor, HUVECs
Imm↑, TumCP↑, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓,
6614- Ech,    Echinacea: a Miracle Herb against Aging and Cancer? Evidence In vivo in Mice
- in-vivo, Var, NA
*Imm↑, *AntiAge↑, OS↑, NK cell↑, PGE2↓, 5LO↓, COX2/PTGS2↓, Dose↝, eff↑,
6613- Ech,    Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system
- Study, Nor, NA
*TNF-α↓, *IL8↓, Imm↑,
6612- Ech,    Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, Nor, NA
*Imm↑, Dose↝, eff↑,
6603- Ech,  doxoR,    The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
- Trial, Var, NA
other∅, other↝, Imm↑, CYP3A4⇅, other↑,
6604- Ech,    Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion
- Human, Nor, NA
*BioAv↑, *Half-Life↝, *Dose↝, Dose?,
6605- Ech,    Bioavailability of Echinacea Constituents: Caco-2 Monolayers and Pharmacokinetics of the Alkylamides and Caffeic Acid Conjugates
- Human, Nor, NA
*Imm↑,
6606- Ech,  Cic,    Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HCT116
TumCP↓, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓, eff↑,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
6608- Ech,  CBC,    The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Casp3↑, TumCD↑,
6609- Ech,  Cic,    Echinacea purpurea Extract Enhances Natural Killer Cell Activity In Vivo by Upregulating MHC II and Th1-type CD4+ T Cell Responses
- in-vivo, Nor, NA
*Dose↝, *CD4+↑, *Th1 response↑, *NK cell↑, *Imm↑,
6610- Ech,  Cic,    A standardized extract of Echinacea purpurea containing higher chicoric acid content enhances immune function in murine macrophages and cyclophosphamide-induced immunosuppression mice
- in-vivo, Nor, NA
*NK cell↑, *Imm↑, Dose↝,
6634- Ech,    Echinacea purpurea: Pharmacology, phytochemistry and analysis methods
- Review, Var, NA
AntiArt↑, *Imm↑, *Neut↑, *NK cell↑, *COX1↓, *COX2/PTGS2↓, *Inflam↓, TumCG↑, *toxicity↓,
6621- Ech,  Cisplatin,    Experimental Evaluation of Protective Activity of Echinacea pallida against Cisplatin Toxicity
- in-vivo, Nor, NA
chemoP↑, RenoP↑,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
6619- Ech,    Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA)
- Review, Nor, NA
*eff↑, *Imm↑, *AntiViral↑,
6618- Ech,    Kaempferols from Echinacea purpurea demonstrate anti-cancer potential by targeting anexelekto in breast cancer therapy using chemoinformatics approach
- Analysis, BC, NA
AXL↓, Dose?,
6617- Ech,    Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
Dose↝, selectivity↑, TumCCA↑, Apoptosis↑, toxicity↓, ChemoSen↑, other↝, *antiOx↑,
7193- EGb 761,  5-FU,    Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
*antiOx↑, AntiCan↑, ChemoSen↑, selectivity↑, EMT↓, E-cadherin↑, Vim↓, HMGB1↓, other↝, chemoPv↑,
7191- EGb 761,    Pharmacokinetic drug interactions involving Ginkgo biloba
- NA, Nor, NA
*other∅, *Dose↝,
7192- EGb 761,    Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases
- in-vitro, Nor, HMEC
Risk↓, *TumCP↓, *TumCMig↓, *angioG↓,
7194- EGb 761,    Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
- in-vitro, Oral, NA
Casp3↑, Apoptosis↑, Dose↝, TumCP↓, cl‑PARP↑, AntiCan↑,
7209- EGb 761,    Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review
- Review, AD, NA
*cognitive↑, *toxicity↓,
7208- EGb 761,    EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
- in-vitro, Nor, SH-SY5Y
*Ca+2↑, *Apoptosis↓, *ROS↓, *MMP↑, *Casp3↓, *Casp9↓,
7203- EGb 761,    Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials
- Review, AD, NA
cognitive↑, QoL↑, Dose↝,
7202- EGb 761,    Ginkgo biloba leaf extract EGb 761® for the treatment of various diseases: Overview of systematic reviews
- Review, AD, NA
*cognitive↑, *Tinn↓, *toxicity↓,
7200- EGb 761,  PCA,    Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference
*Dose↝, *AChE↓, *GSK‐3β↝, *eff↑, *cognitive↑, *toxicity↓,
7196- EGb 761,    Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction-meta-analysis of pooled data from randomised clinical trials
- Review, AD, NA - Review, Stroke, NA
*neuroP↑, *cognitive↑, *Stroke↓, *toxicity↓, Dose↝,
7225- EGb 761,    Efficacy and safety of Ginkgo biloba standardized extract in the treatment of vascular cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial
- Trial, AD, NA
*cognitive↑, *Dose↝, *Dose↝,
7237- EGb 761,    Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway
- in-vitro, HCC, HepG2
TumCG↓, tumCV↓, Apoptosis↑, P53↑, NF-kB↓,
7232- EGb 761,    Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial
- Trial, AD, NA
*cognitive↑, *toxicity↓,

Showing Research Papers: 3301 to 3350 of 8269
Prev Page 67 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↓, 1,   MAD↓, 1,   ROS↓, 1,   ROS↑, 8,   TBARS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CYP3A4⇅, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   LDH↓, 2,   PDH↝, 1,   PDK1 / PDPK1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↑, 12,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 8,   Casp7↑, 2,   Casp9↑, 2,   Cyt‑c↑, 2,   DR4↑, 1,   DR5↑, 1,   HEY1↓, 1,   MAPK↓, 2,   survivin↓, 1,   Telomerase↓, 2,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 3,   other∅, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 7,   P53↑, 4,   cl‑PARP↑, 5,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1/2/5/9↓, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 1,   cycD1/CCND1↓, 4,   cycE1↓, 1,   P21↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CIP2A↓, 1,   EMT↓, 2,   Gli1↓, 1,   HH↓, 1,   IGFBP7↑, 1,   mTOR↓, 1,   mTOR⇅, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   NOTCH3↓, 1,   PI3K↓, 3,   PTEN↑, 1,   Shh↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 3,   TumCG↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AXL↓, 1,   E-cadherin↑, 3,   GLI2↓, 1,   Ki-67↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   NEDD9↓, 1,   PKCδ↓, 1,   SMAD2↓, 1,   SMAD3↓, 2,   SMAD4↓, 1,   Snail↓, 2,   TGF-β↓, 2,   TGF-β↑, 1,   TSC1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 6,   TumCP↑, 1,   TumMeta↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 3,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   NHE1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   HMGB1↓, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 5,   Inflam↓, 1,   NF-kB↓, 3,   p‑NF-kB↓, 1,   NK cell↑, 2,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

i-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 5,   Dose?, 2,   Dose↝, 7,   Dose∅, 3,   eff↑, 11,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   E6↓, 1,   E7↓, 1,   IL6↓, 2,   Ki-67↓, 1,   LDH↓, 2,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,  
Total Targets: 150

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Stroke↓, 1,   Tinn↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ROS↓, 1,   ROS∅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↝, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 1,   IL8↓, 1,   Imm↑, 9,   Inflam↓, 1,   Neut↑, 1,   NK cell↑, 5,   Th1 response↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   MAOB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv∅, 1,   BioEnh↑, 1,   BioEnh↝, 1,   Dose↝, 6,   eff↑, 2,   Half-Life↝, 1,   Half-Life∅, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cognitive↑, 6,   neuroP↑, 1,   toxicity↓, 6,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 43

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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