ER Stress Cancer Research Results

ER Stress, endoplasmic reticulum (ER) stress signaling pathway: Click to Expand ⟱
Source:
Type:
Protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.
The endoplasmic reticulum (ER) stress signaling pathway plays a crucial role in maintaining cellular homeostasis and responding to various stressors, including those encountered in cancer. When cells experience stress, such as the accumulation of misfolded proteins, they activate a series of signaling pathways collectively known as the unfolded protein response (UPR). The UPR aims to restore normal function by enhancing the protein-folding capacity of the ER, degrading misfolded proteins, and, if the stress is unresolved, triggering apoptosis.
The activation of ER stress pathways can contribute to resistance against chemotherapy and targeted therapies. Cancer cells may utilize the UPR to survive treatment-induced stress, making it challenging to achieve effective therapeutic outcomes.

-ER stress-associated proteins include: phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12
Scientific Papers found: Click to Expand⟱
3107- VitC,    Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment
- Review, Var, NA
Risk↓, *ROS↓, ROS↑, VEGF↓, COX2/PTGS2↓, ER Stress↑, IRE1↑, JNK↑, CHOP/DDIT3↑, Hif1a↓, eff↑, Glycolysis↓, MMPs↓, TumMeta↓, YAP/TEAD↓, eff↑, TET1↑,
3110- VitC,    Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
- in-vivo, Nor, NA
*IL2↑, *IL6↑, *IL12↑, *NRF2↑, *Catalase↑, *SOD↑, *GPx↑, *GRP78/BiP↓, *ER Stress↓,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,

Showing Research Papers: 301 to 303 of 303
Prev Page 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 303

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↑, 1,   Glycolysis↓, 1,   lactateProd↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   JNK↑, 1,   YAP/TEAD↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,   IRE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   TET1↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 4,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 2,   GRP78/BiP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL12↑, 1,   IL2↑, 1,   IL6↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   toxicity↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: ER Stress, endoplasmic reticulum (ER) stress signaling pathway
13 Silver-NanoParticles
13 Phenylbutyrate
12 Quercetin
11 Curcumin
11 Berberine
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
8 Ashwagandha(Withaferin A)
8 Licochalcone A
7 Artemisinin
7 Chrysin
7 salinomycin
7 Gambogic Acid
7 Piperlongumine
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Honokiol
6 Kaempferol
6 Luteolin
5 Allicin (mainly Garlic)
5 Resveratrol
5 Rosmarinic acid
5 Sulforaphane (mainly Broccoli)
5 Vitamin C (Ascorbic Acid)
4 Baicalein
4 Betulinic acid
4 Capsaicin
4 Celastrol
4 Propolis -bee glue
4 Emodin
4 Electrical Pulses
4 Shikonin
4 Selenite (Sodium)
3 Photodynamic Therapy
3 Boron
3 Crocetin
3 Copper and Cu NanoParticles
3 Hydrogen Gas
3 HydroxyTyrosol
3 Nimbolide
3 Selenium NanoParticles
2 3-bromopyruvate
2 Andrographis
2 Cisplatin
2 Boswellia (frankincense)
2 Celecoxib
2 Isobavachalcone
2 Isovitexin
2 Plumbagin
2 Pterostilbene
2 Thymoquinone
1 5-Aminolevulinic acid
1 Auranofin
1 Astragalus
1 Radiotherapy/Radiation
1 Alpha-Lipoic-Acid
1 Melatonin
1 immunotherapy
1 Sorafenib (brand name Nexavar)
1 Aloe anthraquinones
1 Berbamine
1 Chemotherapy
1 Bacopa monnieri
1 α-Bisabolol / Chamomile oil
1 doxorubicin
1 Bortezomib
1 Bullatacin
1 Carnosic acid
1 Carvacrol
1 carboplatin
1 Cannabidiol
1 chitosan
1 Choline
1 Cinnamon
1 Coenzyme Q10
1 Cynaropicrin
1 Dichloroacetate
1 Dipyridamole
1 Aspirin
1 Dandelion Root
1 Disulfiram
1 Ellagic acid
1 Ferulic acid
1 Fenbendazole
1 verapamil
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hyperthermia
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoquercitrin
1 Ivermectin
1 Vitexin
1 Lemongrass Extract/Citral
1 Lutein
1 Lycopene
1 Magnolol
1 Magnetic Field Rotating
1 Magnesium
1 Naringin
1 nelfinavir/Viracept
1 Docetaxel
1 Oroxylin-A
1 Oleuropein
1 temozolomide
1 Phenethyl isothiocyanate
1 Parthenolide
1 Paclitaxel/Taxol
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Osimertinib
1 Adagrasib
1 Taurine
1 Urolithin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:103  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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