| Source: HalifaxProj (block) |
| Type: |
| Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation.
TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development. Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment. |
| 7529- | HT, | Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition |
| - | in-vivo, | AD, | NA |
| 7539- | HT, | Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | LoVo |
| 601- | HT, | Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells |
| - | in-vivo, | NA, | HT-29 |
| 7569- | HYP, | Inhibitory effects of hyperoside on lung cancer by inducing apoptosis and suppressing inflammatory response via caspase-3 and NF-κB signaling pathway |
| - | vitro+vivo, | Lung, | A549 |
| 7567- | HYP, | Hyperoside: A review on its sources, biological activities, and molecular mechanisms |
| - | Review, | Var, | NA |
| 7565- | HYP, | Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review |
| - | Review, | AD, | NA |
| 7563- | HYP, | Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury |
| - | vitro+vivo, | Nor, | NA |
| 7560- | HYP, | Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7631- | Ins, | IP6, | Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate |
| - | Review, | Var, | NA |
| 7702- | IP6, | Ins, | capec, | Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model |
| - | in-vivo, | CRC, | NA |
| 7781- | ISL, | Perspectives on the Role of Isoliquiritigenin in Cancer |
| - | Review, | Var, | NA |
| 7784- | ISL, | Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity |
| - | in-vivo, | AD, | NA |
| 7780- | ISL, | Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response |
| - | in-vivo, | Nor, | NA |
| 7779- | ISL, | Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury |
| - | in-vivo, | Alcohol, | NA |
| 7732- | isoFl, | Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity |
| 7866- | isoO, | Orientin and Cancer Suppression: Molecular Mechanisms and Synergistic Effects |
| - | Review, | Var, | NA |
| 7864- | isoO, | Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | AD, | BV2 |
| 7862- | isoO, | Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia |
| - | in-vitro, | Nor, | BV2 |
| 7861- | isoO, | Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7852- | isoO, | Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways |
| - | in-vitro, | AD, | NA |
| 7886- | isoO, | Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo |
| - | vitro+vivo, | Nor, | NA |
| 7884- | isoO, | Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome |
| - | in-vitro, | Nor, | RAW264.7 |
| 7883- | isoO, | Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7875- | isoO, | Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | Nor, | BV2 |
| 7822- | isoO, | Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice |
| - | in-vivo, | AD, | NA |
| 7837- | ISQ, | Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation |
| - | in-vivo, | Nor, | NA |
| 7917- | IVT, | A review on the pharmacological effects of vitexin and isovitexin |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7890- | IVT, | Isovitexin protects against cisplatin-induced kidney injury in mice through inhibiting inflammatory and oxidative responses |
| - | in-vivo, | Nor, | NA |
| 7904- | IVT, | Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress |
| - | in-vivo, | Nor, | NA |
| 5119- | JG, | Juglone Suppresses Inflammation and Oxidative Stress in Colitis Mice |
| - | in-vivo, | Nor, | NA |
| 8085- | KAE, | Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways |
| - | Review, | Var, | NA |
| 8104- | KAE, | A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation |
| - | Review, | Nor, | NA |
| 8105- | KAE, | Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review |
| - | Review, | Var, | NA |
| 8069- | KAE, | Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia |
| - | in-vivo, | AD, | NA |
| 8080- | KAE, | Hepatoprotective Effect of Kaempferol—A Review |
| - | Review, | Nor, | NA |
| 8151- | lamb, | Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 | - | in-vitro, | BC, | MDA-MB-231 |
| 8156- | lamb, | A review on chemistry, source and therapeutic potential of lambertianic acid |
| - | Review, | Var, | NA |
| 8258- | LCA, | Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation |
| - | in-vitro, | Nor, | NA |
| 8221- | LCA, | Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects |
| - | in-vitro, | Nor, | NA |
| 8145- | LF, | Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 8203- | LGE, | Eug, | Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages |
| - | in-vitro, | Nor, | NA |
| 4292- | LT, | Luteolin for neurodegenerative diseases: a review |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | MS, | NA | - | Review, | Stroke, | NA |
| 2921- | LT, | Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies |
| - | Review, | Nor, | NA |
| 2919- | LT, | Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence |
| - | Review, | Var, | NA |
| 2916- | LT, | Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3531- | Lyco, | Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system |
| - | in-vivo, | Nor, | NA |
| 3528- | Lyco, | The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3529- | Lyco, | The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke |
| - | in-vivo, | Nor, | NA |
| 3530- | Lyco, | Lycopene Scavenges Cellular ROS, Modulates Autophagy and Improves Survival through 7SK snRNA Interaction in Smooth Muscle Cells |
| - | in-vitro, | Stroke, | NA |
| 3268- | Lyco, | Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders |
| - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:309 State#:% Dir#:%
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