COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
7883- isoO,    Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *5LO↓, *IL1β↓, *Catalase↑, *GSTs↑,
7875- isoO,    Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, Nor, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
7888- IVT,    Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways
- vitro+vivo, Nor, NA
*Inflam↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Apoptosis↓, *p‑MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *ICAM-1↓, *VCAM-1↓, *MPO↓, *MDA↓, *GSH↑, *SOD↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8102- KAE,    Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
- vitro+vivo, GC, MKN-28 - vitro+vivo, GC, SGC-7901 - in-vitro, GC, GES-1
TumCP↓, TumCCA↑, Apoptosis↑, selectivity↑, TumVol↓, CycB/CCNB1↓, CDK1↓, CDC25↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, p‑Akt↓, p‑ERK↓, COX2/PTGS2↓,
8104- KAE,    A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF-κB inhibition and Nrf2 activation
- Review, Nor, NA
*ROS↓, *Inflam↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *NF-kB↓, *hepatoP↑, *RenoP↑, *cardioP↑, *neuroP↑,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓,
8072- KAE,    Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation
- Review, CRC, NA
AntiCan↑, TumCP↓, TumCI↓, Inflam↓, angioG↓, ROS↑, Apoptosis↑, ChemoSen↑, Risk↓, *antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, *neuroP↑, selectivity↑, PUMA↑, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, NF-kB↓, COX2/PTGS2↓, CC(CDKs/cyclins)↓, TumCCA↑, BioAv↓, eff↑, DR4↑, DR5↑, Casp3↑, Casp9↑, Casp7↑, TumCP↓, TumCI↓, TumAuto↑, mtDam↑, P53↑, MAPK↑, *lipid-P↓, *TAC↑, *Catalase↑, *SOD↑, *GPx↑, *NRF2↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
864- Lae,    Can Amygdalin Provide any Benefit in Integrative Anticancer Treatment?
- Review, NA, NA
TumCCA↑, COX2/PTGS2↝, E-cadherin↑, other∅, other∅,
8154- lamb,    Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
- in-vitro, Nor, NA
*IL6↓, *PGD2↓, *LTC4↓, *COX2/PTGS2↓, *β-HEX↓, *antiAll↑,
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, cl‑PARP↑, p‑STAT3↓, NF-kB↓, XIAP?, survivin↓, Bcl-2↓, Bcl-xL↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ac‑p65↑, Obesity↓, miR-134↑,
8150- lamb,    Reactive oxygen species dependent phosphorylation of the liver kinase B1/AMP activated protein kinase/ acetyl-CoA carboxylase signaling is critically involved in apoptotic effect of lambertianic acid in hepatocellular carcinoma cells
- in-vitro, HCC, HepG2 - in-vitro, HCC, SK-HEP-1
lipidLev↓, TumCCA↑, cl‑Casp3↑, cl‑PARP↑, AMPK↑, Akt↓, mTOR↓, Bcl-2↓, Bcl-xL↓, COX2/PTGS2↓, ROS↑, eff↓, p‑STK11/LKB1↑, p‑ACC↑, *Obesity↓, *Stress↓, *antiAll↑, tumCV↓, selectivity↑, TumCP↓,
8156- lamb,    A review on chemistry, source and therapeutic potential of lambertianic acid
- Review, Var, NA
*Obesity↓, *AntiCan↑, *AMPK↑, *β-HEX↓, NA↑, TumCCA↑, AMPK↑, ACC↑, p‑Akt↓, FOXM1↓, CycB/CCNB1↓, XIAP↓, Bcl-2↓, p‑STAT3↓, p‑NF-kB↓, Bcl-xL↓, survivin↓, VEGF↓, COX2/PTGS2↓, cMyc↓, IL6↓, TNF-α↓, ROS↑, STK11/LKB1↑, cl‑Casp3↑, cl‑PARP↑, eff↑, AR↓, TumCP↓, p‑P53↓, P21↓, p27/CDKN1B↓, cycD1/CCND1↓, CDK4↓, PSA↓, STAT3↓, ac‑p65↓, *antiAll↑,
8175- Las,    Lasiodin Inhibits Proliferation of Human Nasopharyngeal Carcinoma Cells by Simultaneous Modulation of the Apaf-1/Caspase, AKT/MAPK and COX-2/NF-κB Signaling Pathways
- in-vitro, NPC, NA
tumCV↓, TumCMig↓, APAF1↑, Cyt‑c↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, p‑Akt↓, p‑ERK↓, p‑p38↓, p‑JNK↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑,
8255- LCA,    Antitumor and antimetastatic effects of licochalcone A in mouse models
- in-vivo, Colon, NA
COX2/PTGS2↓, iNOS↓, NF-kB↓, AP-1↓, AntiTum↑, β-catenin/ZEB1↓, OS↑, TumMeta↓, MMP9↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
1787- LE,    Licorice and cancer
- Review, Var, NA
Inflam↓, AntiCan↓, DNAdam↓, LOX1↓, COX2/PTGS2↓, PKCδ↓, EGFR↓,
8198- LGE,    Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression
- in-vitro, Var, NA
COX2/PTGS2↓, PPARα↑, PPARγ↑,
8203- LGE,  Eug,    Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages
- in-vitro, Nor, NA
*Inflam↓, *antiOx↑, *AntiP↑, *Dose↝, *toxicity↝, *COX2/PTGS2↓, *TNF-α↓,
1084- LT,  CHr,    Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*COX2/PTGS2↓, *COX2/PTGS2∅, *PGE2↓, *ROS↓,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2/PTGS2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
3275- Lyco,    Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer
- Review, Var, NA
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, P53↑, GSK‐3β↓, p27/CDKN1B↓, Akt↓, mTOR↓, ROS↓, MMPs↓, TumCI↓, TumCMig↓, NF-kB↓, *iNOS↓, *COX2/PTGS2↓, lipid-P↓, GSH↑, NRF2↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
3278- Lyco,    Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells
- in-vitro, Colon, SW480
TNF-α↓, IL1β↓, IL6↓, iNOS↓, COX2/PTGS2↓, PGE2↓, NO↓, NF-kB↓, JNK↓, Inflam↓, MPO↓,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4777- Lyco,    Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells
- in-vitro, GC, AGS
*antiOx↑, tumCV↓, DNAdam↑, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, ROS↓, NF-kB↓, COX2/PTGS2↓, EGFR↓, p38↓,
4781- Lyco,  5-FU,  Chemo,  Cisplatin,    Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells
- in-vitro, Colon, Caco-2
chemoP↑, Inflam↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, ROS↑, ChemoSen↑, SOD↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2/PTGS2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, eff↑,
5252- MAG,    Insights on the Multifunctional Activities of Magnolol
- Review, Var, NA
BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,
1089- MAG,    Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-κB signaling pathways
- in-vitro, AML, RAW264.7
p‑IκB↓, NF-kB↓, p‑ERK↓, p‑JNK↓, p‑PI3K↓, p‑Akt↓, iNOS↓, COX2/PTGS2↓,
1782- MEL,    Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumCG↑, TumMeta↑, ChemoSideEff↓, radioP↑, ChemoSen↑, *ROS↓, *SOD↑, *GSH↑, *GPx↑, *Catalase↑, Dose∅, VEGF↓, eff↑, Hif1a↓, GLUT1↑, GLUT3↑, CAIX/CA9↑, P21↑, p27/CDKN1B↑, PTEN↑, Warburg↓, PI3K↓, Akt↓, NF-kB↓, cycD1/CCND1↓, CDK4↓, CycB/CCNB1↓, CDK4↓, MAPK↑, IGF-1R↓, STAT3↓, MMP9↓, MMP2↓, MMP13↓, E-cadherin↑, Vim↓, RANKL↓, JNK↑, Bcl-2↓, P53↑, Casp3↑, Casp9↑, BAX↑, DNArepair↑, COX2/PTGS2↓, IL6↓, IL8↓, NO↓, T-Cell↑, NK cell↑, Treg lymp↓, FOXP3↓, CD4+↑, TNF-α↑, Th1 response↑, BioAv↝, RadioS↑, OS↑,
2375- MET,    Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling
- in-vitro, GC, SGC-7901
tumCV↓, TumCI↓, TumCMig↓, Apoptosis↑, PARP↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, COX2/PTGS2↓,
3474- MF,    Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration
- in-vitro, Nor, NA
*Inflam↓, *Apoptosis↓, *other↑, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *IL8↓, *cAMP↑, *IL10↑,
538- MF,    The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift
- in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, MSTO-211H
TumCG↓, Ca+2↑, COX2/PTGS2↓, ATP↑, MMP↑, ROS↑, OXPHOS↑, mitResp↑,
2311- MFrot,  MF,    Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
- in-vivo, Nor, HaCaT
*COX2/PTGS2↓, *Inflam↓, *MMP9↑, *GPx↑, *Diff↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3807- mushLions,    Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
*AntiAge↑, *other↑, *NOS2↓, *COX2/PTGS2↓, *P53↑, *neuroP↑,
1141- Myr,    Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
- Review, NA, NA
*PI3K↑, *Akt↑, p‑Akt↓, SIRT3↑, p‑ERK↓, p38↓, VEGF↓, MEK↓, MKK4↓, MMP9↓, Raf↓, F-actin↓, MMP2↓, COX2/PTGS2↓, BMP2↓, cycD1/CCND1↓, Bax:Bcl2↑, EMT↓, EGFR↓, TumAuto↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
1803- NarG,    Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review
- Review, Var, NA
JAK↓, STAT↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, COX2/PTGS2↓, NOTCH↓, TumCCA↑,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6492- Nimb,    Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumCP↓, TumCI↓, angioG↓, TumMeta↓, PTEN↑, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, IKKα↓, CXCR2↓, CXCR4↓, Bcl-2↓, COX2/PTGS2↓, MMP9↓, VEGF↓, TIMP2↑, chemoPv↑, ROS↑, DR4↑, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, Mcl-1↓, XIAP↓, survivin↓, FasL↑, FADD↑, EGFR↓, MMPs↓,

Showing Research Papers: 301 to 350 of 491
Prev Page 7 of 10 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 491

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   miR-134↑, 1,   NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 2,   CYP1A1↓, 2,   CYP1A1↑, 1,   GPx↑, 4,   GSH↑, 3,   GSR↑, 1,   GSTA1↑, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   MPO↓, 1,   NRF2↓, 1,   NRF2↑, 3,   OXPHOS↑, 1,   ROS↓, 5,   ROS↑, 12,   i-ROS↓, 1,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↑, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   mitResp↑, 1,   MKK4↓, 2,   MKK7↓, 1,   MMP↓, 5,   MMP↑, 1,   mtDam↑, 1,   Raf↓, 1,   e-Raf↓, 1,   XIAP?, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   p‑ACC↑, 1,   AMPK↑, 2,   CAIX/CA9↑, 1,   cMyc↓, 4,   p‑cMyc↑, 1,   GLO-I↓, 1,   GlucoseCon↓, 1,   lipidLev↓, 1,   PKM2↓, 1,   PPARα↑, 1,   PPARγ↑, 3,   SIRT1↑, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   p‑Akt↓, 8,   APAF1↑, 2,   Apoptosis↑, 14,   BAX↓, 2,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 10,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↑, 1,   p‑BID↓, 1,   BIM↑, 1,   BMP2↓, 1,   Casp↑, 1,   Casp3↑, 10,   cl‑Casp3↑, 7,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 7,   cl‑Casp9↑, 4,   Chk2↓, 1,   Cyt‑c↑, 3,   DR4↑, 2,   DR5↑, 3,   FADD↑, 1,   FasL↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 6,   JNK↓, 2,   JNK↑, 2,   p‑JNK↓, 2,   MAPK↓, 1,   MAPK↑, 3,   Mcl-1↓, 2,   p‑Mcl-1↓, 1,   MDM2↓, 1,   necrosis↑, 1,   NICD↓, 1,   p27/CDKN1B↓, 2,   p27/CDKN1B↑, 2,   p38↓, 4,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 8,   Telomerase↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other∅, 2,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 3,   HSP90↓, 2,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   CHK1↓, 1,   DNAdam↓, 2,   DNAdam↑, 6,   DNArepair↑, 1,   P53↓, 1,   P53↑, 9,   p‑P53↓, 1,   PARP↓, 1,   cl‑PARP↑, 10,   PCNA↓, 4,   γH2AX↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 5,   p‑CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 8,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 3,   P21↓, 1,   P21↑, 8,   TumCCA↑, 17,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CTSB↓, 1,   CTSD↓, 1,   EMT↓, 4,   ERK↓, 3,   p‑ERK↓, 5,   FOXM1↓, 1,   FOXO3↓, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 2,   IGF-1?, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 11,   p‑PI3K↓, 1,   PTEN↑, 3,   RAS↓, 2,   STAT↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   TAZ↓, 1,   TumCG↓, 2,   TumCG↑, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 2,   Ca+2↑, 2,   i-Ca+2↑, 1,   CC(CDKs/cyclins)↓, 1,   CD31/PECAM-1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 5,   F-actin↓, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP2↓, 8,   MMP3↓, 1,   MMP7↓, 4,   MMP9↓, 13,   MMPs↓, 2,   N-cadherin↓, 3,   PKCδ↓, 1,   Slug?, 1,   Snail?, 1,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 4,   Treg lymp↓, 1,   TumCA↓, 1,   TumCI↓, 7,   TumCMig↓, 5,   TumCP↓, 13,   TumMeta↓, 4,   TumMeta↑, 2,   VCAM-1↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 5,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 4,   Hif1a↓, 6,   LOX1↓, 1,   NO↓, 2,   VEGF↓, 12,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 26,   COX2/PTGS2↝, 1,   CXCR2↓, 1,   CXCR4↓, 2,   FOXP3↓, 1,   FOXP3↑, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1↑, 1,   IL10↑, 1,   IL1β↓, 2,   IL2↑, 1,   IL4↑, 2,   IL6↓, 7,   IL8↓, 1,   Inflam↓, 5,   p‑IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   NF-kB↓, 17,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PGE2↓, 4,   PSA↓, 1,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TNF-α↓, 6,   TNF-α↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   GR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↓, 1,   ChemoSen↑, 9,   Dose↑, 1,   Dose↝, 3,   Dose∅, 1,   eff↓, 1,   eff↑, 7,   MDR1↓, 1,   RadioS↑, 2,   selectivity?, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   p‑BRCA1↑, 1,   EGFR↓, 4,   FOXM1↓, 1,   hTERT/TERT↓, 1,   IL6↓, 7,   Ki-67↓, 1,   PSA↓, 1,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 5,   AntiTum↑, 2,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   Obesity↓, 1,   OS↑, 3,   QoL↑, 1,   radioP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 300

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

antiAll↑, 4,   AntiBio↑, 2,   AntiP↑, 1,   LTC4↓, 1,   Stress↓, 1,   Stroke↓, 1,   β-HEX↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 12,   ARE↑, 1,   Catalase↑, 7,   CYP2E1↓, 2,   GPx↑, 7,   GSH↑, 5,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 3,   lipid-P↓, 3,   MDA↓, 3,   MPO↓, 2,   NRF2↑, 7,   ROS↓, 17,   SOD↑, 10,   TAC↑, 2,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

p‑MKK4↑, 1,   MMP↑, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 2,   cAMP↑, 1,   DGAT1↓, 1,   FASN↓, 1,   LDL↓, 1,   lipidLev↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 2,   BMP2↑, 1,   Casp3↓, 2,   Casp8↓, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   iNOS↓, 9,   p‑JNK↓, 1,   MAPK↓, 1,   p‑MAPK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   PI3K↑, 1,   RUNX2↑, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   5LO↝, 1,   AntiAg↑, 1,   AP-1↓, 1,   Cartilage↑, 1,   COL1↓, 1,   COL1↑, 1,   MMP1↓, 1,   MMP9↑, 1,   MMPs↓, 1,   RAGE↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   TGF-β1↑, 1,   VCAM-1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 24,   COX2/PTGS2∅, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 6,   IL6↓, 14,   IL8↓, 1,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 15,   IκB?, 1,   NF-kB↓, 12,   PGD2↓, 1,   PGE2↓, 6,   TLR4↓, 1,   TNF-α↓, 11,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   NLRP3↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 2,   BioEnh↑, 1,   Dose↝, 3,   eff↑, 4,   Half-Life↑, 1,   Half-Life↝, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   GutMicro↑, 1,   IL6↓, 14,   NOS2↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 8,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 8,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Bacteria↑, 1,  
Total Targets: 141

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
28 Curcumin
25 Thymoquinone
19 Quercetin
18 Resveratrol
15 Fisetin
12 Lycopene
11 Celecoxib
11 Chrysin
11 Silymarin (Milk Thistle) silibinin
10 Apigenin (mainly Parsley)
10 Propolis -bee glue
10 Eugenol
9 Boswellia (frankincense)
9 Carvacrol
9 isoorientin
9 Sulforaphane (mainly Broccoli)
8 Berberine
8 Beta-Caryophyllene
8 Diclofenac
7 Artemisinin
7 EGCG (Epigallocatechin Gallate)
7 Honokiol
7 Kaempferol
7 Rosmarinic acid
6 Chlorogenic acid
6 Ginger/6-Shogaol/Gingerol
5 Radiotherapy/Radiation
5 Baicalein
5 Echinacea
5 Ellagic acid
5 Ferulic acid
5 Garcinol
5 Piperine
4 Aspirin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Cisplatin
4 lambertianic acid
4 Shikonin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Isovitexin
3 Betulinic acid
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cichoric acid / Chicoric acid
3 Chemotherapy
3 D-limonene
3 Dandelion Root
3 Formononetin
3 Gambogic Acid
3 Grapeseed extract
3 Isoliquiritigenin
3 Luteolin
3 Magnetic Fields
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Rutin
2 acetaminophen
2 Allicin (mainly Garlic)
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Baicalin
2 xanthohumol
2 Cannabidiol
2 Boron
2 buckwheat sprouts
2 Caffeic acid
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Chocolate
2 Crocetin
2 Ursolic acid
2 CUSP9
2 Docosahexaenoic Acid
2 Emodin
2 Genistein (soy isoflavone)
2 Geraniol
2 Hydroxycinnamic-acid
2 Hyperoside
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Vitexin
2 Licorice
2 Lemongrass Extract/Citral
2 Magnolol
2 Naringin
2 Nimbolide
2 Oleuropein
2 Oleocanthal
2 Piperlongumine
2 Vitamin C (Ascorbic Acid)
2 Vitamin K2
1 1,8-Cineole
1 Auranofin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Bruteridin(bergamot juice)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 cannabidiolic acid
1 Celastrol
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Lecithin
1 Oxygen, Hyperbaric
1 Docetaxel
1 Galantamine
1 Dichloroacetate
1 Date Fruit Extract
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 flavonoids
1 Bortezomib
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Proanthocyanidins
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 Hops (Humulus lupulus)
1 Inositol
1 iodine
1 Laetrile B17 Amygdalin
1 Lasiodin
1 Licochalcone A
1 5-fluorouracil
1 Melatonin
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 Myricetin
1 Neem
1 Protocatechuic acid
1 Mung Bean Sprouts
1 Polyphenols
1 Perilla
1 Germacranolide sesquiterpene lactone
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Aflavin-3,3′-digallate
1 doxorubicin
1 Turmerones
1 Vitamin B1/Thiamine
1 Whole Body Vibration
1 Wogonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:66  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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