Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
1331- EMD,    Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
- in-vitro, NPC, NA
TumCCA↑, CycB/CCNB1↑, DNAdam↑, Casp3↑, cl‑PARP↑, MMP↓, Ca+2↑, ROS↑,
1296- EMD,    Emodin inhibits LOVO colorectal cancer cell proliferation via the regulation of the Bcl-2/Bax ratio and cytochrome c
- in-vitro, CRC, LoVo
BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, NA, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
1247- EMD,    Emodin exerts antitumor effects in ovarian cancer cell lines by preventing the development of cancer stem cells via epithelial mesenchymal transition
- vitro+vivo, Ovarian, SKOV3 - in-vitro, Ovarian, A2780S
TumCP↓, TumCMig↓, TumCI↓, EMT↓, N-cadherin↓, Vim↓, E-cadherin↑, TumCG↓, CD133↓, OCT4↓, CSCs↓,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
1246- EMD,    Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation
- in-vivo, BC, NA
TGF-β↓, EMT↓, CSCs↓,
7045- EMD,  TSG,    Synergic effects and possible mechanism of emodin and stilbene glycosides on colorectal cancer
- vitro+vivo, CRC, NA
Apoptosis↑, TumCMig↓, TumVol↓, IL6↓, TGF-β↓, i-P53↓, i-STAT3↓,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6824- EMD,    Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer’s Dementia: A Systematic Review
- Review, AD, NA
*Inflam?, *antiOx↑, *tau↓, *Aβ↓, *neuroP↑, *ROS↓, *memory↑, *cognitive↑, *other↝, *AChE↓, *BACE/β-secretase↓, *LC3II↓, *Beclin-1/ATG6↓, *p‑tau↓, *CREB↑, *HNE↓, *BioAv↓, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, BioAv↑, *HO-1↑, *PKCδ↑, *Akt↑, *NLRP3↓, *NF-kB↓, *TLR3↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓,
6815- EMD,    NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- in-vitro, Liver, HepG2
AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *AntiBio↑, *toxicity↝, tumCV↓, TumCP↓, Apoptosis↑, ALAT↓, glucose↓, GSH↓, ATP↓,
6816- EMD,    Emodin attenuates Alzheimer's disease by activating the protein kinase C signaling pathway
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *p‑PKCδ↑, *ROS↓,
6817- EMD,    Emodin inhibits aggregation of amyloid-β peptide 1–42 and improves cognitive deficits in Alzheimer's disease transgenic mice
- in-vivo, AD, NA
*Aβ↓, *tau↓, *ROS↓, *Inflam↓, *cognitive↑,
6818- EMD,    Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer's Disease-Like Features in Rats
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *PP2A↑, *cAMP↑, *5LO↓, *IL6↓, *TNF-α↓, *ROS↓, *DNMT1↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, eff↑, MMP2↓, MMP9↓, eff↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, eff↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?,
6821- EMD,    Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection
- Study, AD, NA
*ROS↓, *Aβ↓,
6822- EMD,    Behavioral, Histopathological, and Biochemical Implications of Aloe Emodin in Copper-Aβ-Induced Alzheimer's Disease-like Model Rats
- in-vivo, AD, NA
*Copper↓, *Aβ↓, *memory↑, *cognitive↑, *Apoptosis↓, *TAC↑, *Inflam↓,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
6826- EMD,    Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties
*AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *Bacteria↓, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓, *PP2A↑,
6827- EMD,    Mechanism of Emodin in the Treatment of Rheumatoid Arthritis
- Review, Arthritis, NA
*ALAT↓, *AST↓, *ROS↓, *cardioP↑, *TNF-α↓, *NF-kB↓, *Inflam↓, *AntiArt↑, *PGE2↓, *MMP3↓, *MMP13↓, *COX2/PTGS2↓, *AntiCan↑, *neuroP↑, *hepatoP↑,
6828- EMD,    Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice
- in-vitro, AD, U251
*MMP↑, *ROS↓, *NRF2↑, *HO-1↑, *SOD↑, *Bcl-2↑, *Catalase↑, *BAX↓, *memory↑, *ANXi↓, *Aβ↓, *antiOx↑, *MDA↓,
6829- EMD,    Molecular Mechanisms of Action of Emodin: As an Anti-Cardiovascular Disease Drug
*diuretic↑, *Bacteria↓, *AntiViral↑, *Inflam↓, AntiCan↑, *cardioP↑, *NF-kB↓, *TNF-α↓, *IL1β↓, *NO↑, *eNOS↑, *PPARγ↑, *Casp9↓, *Casp3↓, *GSDMD↓, *Bcl-2↑, *STAT3↑, *ATP↑, *SOD↑, *GSH↑, *HDAC2↓, *SIRT3↑, ROS↑, PCNA↓, P53↑, cMyc↓,
6830- EMD,    Anticancer activity of emodin is associated with downregulation of CD155
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, E0771 - in-vitro, BC, 4T1
TumCP↓, TumCMig↓, TumCCA↑, CD155↓, Dose↓, other↝, TumCG↓,
6831- EMD,  PI,    Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats
- in-vivo, Nor, NA
*BioAv↑,
6832- EMD,    Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
- in-vitro, Cerv, HeLa
Cyt‑c↑, APAF1↑, Fas↑, FasL↑, FADD↑, proCasp9↓, proCasp8↓, proCasp3↓, TumCP↓, Apoptosis↑, Casp9↑, Casp8↑, Casp3↑,
6833- EMD,    Anticancer potential of emodin
- Review, Var, NA
Inflam↓, angioG↓, TumCCA↑, Apoptosis↑, HIF-1↓, TumCI↓, TumCMig↓, HER2/EBBR2↓, CK2↓, ROS↑, AR↓, JAK2↓, STAT3↓, Mcl-1↓, NAT↓, ChemoSen↑, survivin↓, XIAP↓, NF-kB↓, *neuroP↑, *hepatoP↑,
6834- EMD,    Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9
- in-vitro, Cerv, HeLa
AntiCan↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, TumCD↑, DNAdam↑,
6835- EMD,    Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin
- in-vitro, BC, NA
HER2/EBBR2↓, TumCG↓, Diff↑,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
3830- EMD,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *BACE/β-secretase↓,
950- EMD,    Emodin Decreases Hepatic Hypoxia-Inducible Factor-1[Formula: see text] by Inhibiting its Biosynthesis
- in-vivo, NA, NA - in-vitro, Liver, HepG2
HIF-1↓,
988- EMD,    Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS
- in-vitro, RCC, NA
Necroptosis↑, p‑RIP1↑, MLKL↑, ROS↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
5227- EMD,    Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy
- vitro+vivo, Nor, NA
*cardioP↑, HDAC↓, HDAC1↓, HDAC2↓, ac‑H3↑, Dose↝, BioAv↓,
5226- EMD,    Emodin and rhein decrease levels of hypoxia-inducible factor-1α in human pancreatic cancer cells and attenuate cancer cachexia in athymic mice carrying these cells
- vitro+vivo, Pca, MIA PaCa-2
Hif1a↓, TumCG↓, cachexia↓,
5225- EMD,    Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
- vitro+vivo, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
STAT3↓, Akt↓, cSrc↓, JAK1↓, JAK2↓, SHP1↑, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCP↓, Casp3↑, cl‑PARP↑, ChemoSen↑, XIAP↓,
5224- EMD,    Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-α and IL-6 Release by Blockading NF-κB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
NF-kB↓, p‑IKKα↓, p‑MAPK↓, ERK↓,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
2422- EMD,    Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling
- in-vitro, HCC, HepG2
HK2↓, PKM2↓, LDHA↓, Glycolysis↓, TumCCA↑, ROS↓, glut↓, Hif1a↓,
2345- EMD,    Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation
- in-vitro, AD, PC12
*PKM2↓, *neuroP↑,
3460- EP,    Picosecond pulsed electric fields induce apoptosis in HeLa cells via the endoplasmic reticulum stress and caspase-dependent signaling pathways
- in-vitro, Cerv, HeLa
tumCV↓, Apoptosis↑, TumCCA↑, GRP78/BiP↑, GRP94↑, CEBPA↑, CHOP/DDIT3↑, Ca+2↑, Casp12↑, Casp9↑, Casp3↑, Cyt‑c↑, BAX↑, Bcl-2↓, ER Stress↑, MMP↓,
5256- EP,    Pulsed electric fields: a sharp sword in the battle against cancers
- Review, Var, NA
BioAv↑, TumCD↑, MMP↓, Apoptosis↑, TumCCA↑, Imm↑, RadioS↑, ChemoSen↑,
6110- EP,    Leukemic cell intracellular responses to nanosecond electric fields
- in-vitro, AML, NA
eff↑, EPR↑, other↝, other↝, Dose↝, Dose↝, Dose↝, eff↑,
5525- EP,    Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs)
- Review, Var, NA
CellMemb↑, Ca+2↑, ER Stress↑, ROS↑, MMP↓, VGCC↓, VGSC↓, Dose↝,
5530- EP,    Expression of voltage-gated calcium channels augments cell susceptibility to membrane disruption by nanosecond pulsed electric field
- in-vitro, Nor, HEK293
*CellMemb↑, *VGCC↑, *Ca+2↑, *MMP↓, *VGCC⇅, eff↑,
5526- EP,    Nanosecond Pulsed Electric Field Modulates Electron Transport and Mitochondrial Structure and Function
- Review, Var, NA
CellMemb↑, ROS↑, ETC↝, OCR↓, MMP↓,
5529- EP,    Effects of nsPEFs on Electron Transport and Mitochondrial Structures and Functions
- Review, Var, NA
ETC↓, OCR↓, CellMemb↑, mt-ROS↑, MMP↓,
5528- EP,    Nanosecond pulsed electric fields mimic natural cell signal transduction mechanisms
- Review, Var, NA
Apoptosis↑, CA↑, Wound Healing↑,
5527- EP,    Nanosecond pulsed electric field (nsPEF) application effects on human cells: intracellular membrane disruption and apoptosis induction
- in-vivo, Var, NA
*Dose↓, Apoptosis↑, DNAdam↑, mtDam↑,

Showing Research Papers: 3551 to 3600 of 8269
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD155↓, 1,   NAT↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 2,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 11,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ETC↓, 1,   ETC↝, 1,   MMP↓, 11,   mtDam↑, 2,   OCR↓, 2,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   cMyc↓, 2,   glucose↓, 1,   glut↓, 1,   Glycolysis↓, 4,   HK2↓, 2,   LDHA↓, 2,   PKM2↓, 2,   SREBP2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   APAF1↑, 1,   Apoptosis↑, 15,   BAX↑, 6,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Bcl-xL↓, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 10,   proCasp3↓, 1,   Casp7↑, 1,   Casp8↑, 1,   proCasp8↓, 1,   Casp9↑, 7,   proCasp9↓, 1,   CK2↓, 1,   Cyt‑c↑, 6,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   p‑MAPK↓, 1,   Mcl-1↓, 3,   MLKL↑, 1,   MOMP↑, 1,   Necroptosis↑, 2,   p‑RIP1↑, 1,   survivin↓, 2,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   other↝, 4,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   GRP94↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↑, 3,   i-P53↓, 1,   PARP↓, 1,   cl‑PARP↑, 4,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CEBPA↑, 1,   CSCs↓, 4,   Diff↓, 1,   Diff↑, 1,   EMT↓, 4,   ERK↓, 1,   ERK5↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   miR-34a↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 4,   SHP1↑, 1,   STAT↓, 1,   STAT3↓, 4,   i-STAT3↓, 1,   TumCG↓, 6,   TumCG↑, 1,   VGCC↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   CA↑, 1,   Ca+2↑, 3,   E-cadherin↑, 2,   Ki-67↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↓, 2,   PKCδ↓, 2,   Slug↓, 1,   TGF-β↓, 3,   TRIB3↑, 1,   TumCI↓, 5,   TumCMig↓, 4,   TumCP↓, 9,   TumCP↑, 1,   TumMeta↓, 2,   TumMeta↑, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EPR↑, 1,   HIF-1↓, 2,   Hif1a↓, 2,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 3,   GLUT1↓, 2,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1,   p‑IKKα↓, 1,   IL12↑, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 1,   JAK1↓, 1,   JAK2↓, 2,   NF-kB↓, 4,   NF-kB↑, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 6,   Dose↓, 1,   Dose↝, 5,   eff↑, 10,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↓, 1,   HER2/EBBR2↓, 3,   IL6↓, 2,   Ki-67↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 1,   cachexia↓, 1,   OS↑, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 1,   Wound Healing↑, 1,  
Total Targets: 167

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 2,   diuretic↑, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Catalase↑, 1,   Copper↓, 1,   GPx↑, 1,   GSH↑, 2,   HNE↓, 1,   HO-1↑, 3,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 10,   SIRT3↑, 1,   SOD↑, 3,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 1,   MMP↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 2,   cAMP↑, 1,   CREB↑, 1,   glucose↓, 1,   NAD↓, 1,   PKM2↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   GADD34↓, 1,   GSDMD↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,   LC3II↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   HDAC↓, 1,   HDAC2↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,   STAT3↑, 1,   VGCC↑, 1,   VGCC⇅, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Ca+2↑, 1,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 1,   PKCδ↑, 2,   p‑PKCδ↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   eNOS↑, 1,   Hif1a↓, 2,   NO↓, 1,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam?, 1,   Inflam↓, 12,   Inflam↑, 1,   JAK↓, 1,   MyD88↓, 1,   NF-kB↓, 6,   PGE2↓, 2,   TLR3↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↓, 1,   tau↓, 3,   p‑tau↓, 4,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 9,   BACE/β-secretase↓, 3,   NLRP3↓, 2,   PP2A↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 2,   Dose↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   GutMicro↑, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 4,   AntiTum↑, 1,   ANXi↓, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 4,   hepatoP↑, 8,   memory↑, 3,   neuroP↑, 9,   Obesity↓, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↝, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 5,  
Total Targets: 123

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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