selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱
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The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability
Scientific Papers found: Click to Expand⟱
5041- SAS,  Cisplatin,    Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism
- in-vitro, CRC, NA
xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4484- Se,  Chit,  PEG,    Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
4715- Se,    The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells
chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,
4734- SeNPs,  CPT-11,    Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles
- in-vitro, CRC, HCT8 - in-vivo, NA, NA
chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,
4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, eff↑, *eff↑,
4480- SeNPs,  Chit,    Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
- in-vitro, Lung, A549 - in-vitro, Nor, HK-2
selectivity↑, *toxicity↓, ROS↑, mtDam↑, Apoptosis↑, LDH↑,
4501- SeNPs,    Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines
- in-vitro, GBM, A172 - in-vitro, Colon, Caco-2 - in-vitro, Pca, DU145 - in-vitro, BC, MCF-7 - in-vitro, Nor, L929
*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,
4469- SeNPs,    Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential
- Review, Var, NA
antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,
4471- SeNPs,    Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis
- in-vitro, Liver, HepG2
eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,
4472- SeNPs,    Therapeutic potential of selenium nanoparticles
- Review, Var, NA
*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,
4473- SeNPs,    Anti-cancerous effect and biological evaluation of green synthesized Selenium nanoparticles on MCF-7 breast cancer and HUVEC cell lines
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
AntiCan↑, selectivity↓, *Bacteria↓, *antiOx↑, *toxicity↓, ROS↑, tumCV↓,
4449- SeNPs,    PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction
- in-vitro, Liver, HepG2
MMP↓, selectivity↑, Apoptosis↑, ROS↑,
4448- SeNPs,    Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies
- Review, Nor, NA
*toxicity↓, *toxicity↓, selectivity↑, *antiOx↑, *cognitive↑, *other↝, TumCCA↑,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, NA, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
4457- SeNPs,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
2166- SFN,    Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction
- in-vitro, Oral, NA - in-vivo, NA, NA
CSCs↓, selectivity↑, TumCMig↓, TumCI↓,
1734- SFN,    Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia
- in-vitro, Bladder, RT112
selectivity↑, TumCP↓, Glycolysis↓, Hif1a↓,
1736- SFN,    Antitumor and antimetastatic effects of dietary sulforaphane in a triple-negative breast cancer models
- in-vitro, BC, NA - in-vivo, BC, NA
TumCG↓, selectivity↓,
1498- SFN,    Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460
selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,
1502- SFN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
HDAC↓, AntiCan↑, DNMTs↓, hTERT/TERT↓, selectivity↑,
1497- SFN,    Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
- in-vitro, Nor, PrEC - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,
1494- SFN,  doxoR,    Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- in-vivo, BC, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,
3299- SIL,    Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells
- in-vitro, Colon, HT29
tumCV↓, MMP↓, ROS↑, selectivity↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,
2185- SK,    Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- in-vitro, Lung, LLC1 - in-vitro, Melanoma, B16-BL6 - in-vivo, NA, NA
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, selectivity↑, Warburg↓, TumVol↓, TumW↓,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2226- SK,    Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
- in-vitro, HCC, HUH7 - in-vitro, HCC, Bel-7402
selectivity↑, ROS↑, eff↓, Akt↓, RIP1↓, NF-kB↓,
3048- SK,    Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, 4T1 - in-vitro, Nor, MCF12A - in-vivo, NA, NA
tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,
2009- SK,    Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer
- in-vitro, Bladder, NA
TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,
2008- SK,  Cisplatin,    Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,
2007- SK,    Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
- in-vitro, lymphoma, U937 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3 - in-vitro, CRC, HCT116 - in-vitro, OS, U2OS - NA, Nor, RPE-1
tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
977- SK,    A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, HMEC
TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
4742- SSE,    Antitumor Effects of Selenium
- Review, Var, NA - Review, Arthritis, NA - Review, Sepsis, NA
*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,
5078- SSE,  Rad,    Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer
- Trial, Pca, NA
Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,
5074- SSE,    Application of Sodium Selenite in the Prevention and Treatment of Cancers
- Review, Var, NA
Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,
5093- SSE,    Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice
- in-vivo, Var, NA
AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,
5110- SSE,    Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells
- in-vitro, AML, APL NB4
Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,
5088- SSE,    Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
- in-vitro, BC, MCF-7 - in-vitro, GBM, U87MG - in-vitro, Pca, PC3 - in-vitro, Cerv, HeLa - in-vitro, GBM, A172
Ferroptosis↑, ROS↑, Iron↑, xCT↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,
5086- SSE,    Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, T98G - in-vitro, GBM, A172
TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,
5327- TFdiG,    Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells
- in-vitro, Ovarian, A2780S
TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,

Showing Research Papers: 351 to 400 of 431
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 431

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 7,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↑, 1,   Keap1↑, 1,   lipid-P↑, 2,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 1,   NRF2∅, 1,   Prx↓, 1,   PrxI↓, 1,   ROS↓, 2,   ROS↑, 27,   i-ROS↑, 1,   SOD↓, 1,   Trx↓, 1,   xCT↓, 3,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 15,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDH↓, 1,   LDH↑, 1,   PKM2↓, 1,   SIRT1↓, 1,   SREBP1↓, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 15,   BAD↑, 1,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-xL↓, 1,   BID↑, 1,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp9↑, 5,   Cyt‑c↑, 6,   Diablo↑, 1,   Endon↑, 1,   Ferroptosis↑, 1,   GADD34↑, 1,   hTERT/TERT↓, 1,   IAP1↑, 1,   ICAD↑, 1,   MDM2↓, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27↑, 1,   PUMA↑, 1,   RIP1↓, 1,   survivin↓, 1,   Telomerase↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,   HATs↑, 1,   other↑, 2,   other↝, 1,   tumCV↓, 9,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 4,   HSP27↑, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,   p62↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 8,   DNArepair↓, 1,   DNArepair↑, 1,   DNMTs↓, 3,   P53↑, 3,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycD1/CCND1↓, 1,   P21↑, 2,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cMYB↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 1,   GSK‐3β↑, 1,   HDAC↓, 5,   IGFBP3↑, 1,   NOTCH↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 10,   Wnt↓, 1,  

Migration ⓘ

CA↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   E-cadherin↑, 2,   ER-α36↓, 1,   FAK↓, 1,   miR-203↑, 1,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   Smad1↑, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 4,   uPA↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   angioG↑, 1,   EGFR↓, 2,   EPR↑, 1,   Hif1a↓, 3,   VEGF↓, 4,  

Barriers & Transport ⓘ

AQPs↓, 1,   BBB↑, 1,   NHE1↓, 1,   P-gp↓, 1,   sonoP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1↓, 1,   IL2↑, 1,   Imm↑, 2,   INF-γ↑, 1,   Inflam↓, 2,   NF-kB↓, 2,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 2,   Th1 response↑, 1,   Th2↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   ERα/ESR1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   ChemoSen↑, 8,   Dose↑, 4,   Dose↝, 6,   eff↓, 7,   eff↑, 18,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 3,   RadioS↓, 1,   RadioS↑, 4,   selectivity?, 1,   selectivity↓, 3,   selectivity↑, 55,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 3,   AST↓, 1,   EGFR↓, 2,   ERα/ESR1↓, 1,   hTERT/TERT↓, 1,   LDH↓, 1,   LDH↑, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 11,   AntiCan∅, 1,   AntiTum↑, 2,   cardioP↑, 2,   CardioT↓, 1,   chemoP↑, 5,   chemoPv↑, 2,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 2,   Remission↑, 1,   Risk↓, 2,   Risk↑, 1,   toxicity↓, 1,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 202

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 6,   GPx↑, 2,   GSH↑, 4,   lipid-P↓, 1,   NRF2↑, 4,   ROS↓, 3,   selenoP↑, 2,   SOD↑, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Cyt‑c↓, 1,   IAP1↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 3,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   GADD45A↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Migration ⓘ

AntiAg↑, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 6,   TNF-α↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 6,   Dose↝, 3,   eff↑, 6,   Half-Life↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   creat↓, 1,   CRP↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cognitive↑, 1,   Pain↓, 1,   radioP↑, 2,   toxicity↓, 13,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 5,  
Total Targets: 47

Scientific Paper Hit Count for: selectivity, selectivity
35 Silver-NanoParticles
27 Magnetic Fields
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
12 Radiotherapy/Radiation
12 Betulinic acid
11 Chemotherapy
10 salinomycin
10 Phenethyl isothiocyanate
10 Shikonin
9 Vitamin C (Ascorbic Acid)
9 Capsaicin
9 Propolis -bee glue
9 chitosan
9 Dichloroacetate
9 Sulforaphane (mainly Broccoli)
8 doxorubicin
8 Carvacrol
8 Copper and Cu NanoParticles
8 Honokiol
8 Magnetic Field Rotating
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
6 Apigenin (mainly Parsley)
6 Baicalein
6 EGCG (Epigallocatechin Gallate)
6 Fisetin
6 Hydrogen Gas
5 3-bromopyruvate
5 Rosmarinic acid
5 Ashwagandha(Withaferin A)
5 Melatonin
5 Curcumin
5 Cisplatin
5 Selenium
5 HydroxyTyrosol
4 Alpha-Lipoic-Acid
4 Metformin
4 Phenylbutyrate
4 Boron
4 diet FMD Fasting Mimicking Diet
4 Ellagic acid
4 Lycopene
4 Magnolol
4 Parthenolide
4 VitK3,menadione
3 chemodynamic therapy
3 Fenbendazole
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Chrysin
3 Citric Acid
3 diet Methionine-Restricted Diet
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Gold NanoParticles
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Coenzyme Q10
2 Hydroxycinnamic-acid
2 Date Fruit Extract
2 Oxygen, Hyperbaric
2 Disulfiram
2 Electrical Pulses
2 Gambogic Acid
2 Graviola
2 Luteolin
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 diet Ketogenic
1 PXD, phenoxodiol
1 Emodin
1 Juglone
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 Hyperthermia
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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