TNF-α Cancer Research Results

TNF-α, TNF-α: Click to Expand ⟱
Source: HalifaxProj (block)
Type:
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, *Mood↑, *neuroP↑, *Inflam↓, *TNF-α↓, *BBB↝, *other↝, *Dose↝,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, NA, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,
3149- VitC,    Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *IL6↓, *ER Stress↓, *ATF6↓, *eIF2α↓, *GRP78/BiP↓, *XBP-1↓, *Inflam↓,
3128- VitC,    Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages
- in-vitro, Nor, NA
*ROS↓, *DNAdam↓, *TNF-α↓, *IL6↓, *p38↓,
3131- VitC,    Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model
- in-vivo, Nor, NA
*MMP2↓, *MMP9↓, *TNF-α↓, *IL1β↓, *TIMP2↑, *TIMP1↓, *antiOx↑, *Inflam↓,
2368- VitD3,    Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice
- in-vivo, Obesity, NA
*Weight↓, *TNF-α↓, *IL1β↓, LPS↓, *ZO-1↑, *GutMicro↑,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
2277- VitK2,    Vitamin K2 suppresses rotenone-induced microglial activation in vitro
- in-vitro, Nor, BV2 - NA, AD, NA - NA, Park, NA
*p38↓, *ROS↓, *Casp1↓, *MMP↑, *NF-kB↓, *IL1β↓, *iNOS↓, *COX2↓, *TNF-α↓,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,

Showing Research Papers: 351 to 360 of 360
Prev Page 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 360

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   H2O2↑, 1,   ROS↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↝, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   IL2↓, 1,   IL8↓, 1,   LPS↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   Dose↑, 1,   Dose↝, 1,   Half-Life↝, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   HO-1↑, 1,   Keap1↓, 1,   NRF2↑, 1,   ROS↓, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   NAD↑, 1,   NADPH↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Casp1↓, 1,   iNOS↓, 2,   p38↓, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   TGF-β↓, 1,   TIMP1↓, 2,   TIMP2↑, 1,   ZO-1↑, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1β↓, 3,   IL2↓, 1,   IL5↓, 1,   IL6↓, 3,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 8,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   Albumin↑, 1,   AST↓, 2,   GutMicro↑, 1,   IL6↓, 3,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   Mood↑, 1,   neuroP↑, 2,   toxicity↝, 1,   Weight↓, 1,  
Total Targets: 50

Scientific Paper Hit Count for: TNF-α, TNF-α
19 Thymoquinone
17 Quercetin
15 Lycopene
15 Silymarin (Milk Thistle) silibinin
13 Hydrogen Gas
12 Boron
12 Curcumin
12 Magnetic Fields
11 Silver-NanoParticles
11 Propolis -bee glue
9 Rosmarinic acid
9 Shikonin
8 Berberine
8 EGCG (Epigallocatechin Gallate)
8 Sulforaphane (mainly Broccoli)
7 Resveratrol
7 Honokiol
6 Alpha-Lipoic-Acid
6 Baicalein
6 Boswellia (frankincense)
6 Chlorogenic acid
6 Chrysin
6 Urolithin
5 Ashwagandha(Withaferin A)
5 Selenium NanoParticles
5 Fisetin
4 Astragalus
4 Apigenin (mainly Parsley)
4 Artemisinin
4 Selenium
4 Capsaicin
4 Carvacrol
4 Celastrol
4 Luteolin
4 Vitamin C (Ascorbic Acid)
3 Citric Acid
3 beta-glucans
3 Cisplatin
3 Folic Acid, Vit B9
3 Vitamin B3,Niacin
3 Butyrate
3 Thymol-Thymus vulgaris
3 Coenzyme Q10
3 Piperine
3 Pterostilbene
2 5-fluorouracil
2 Allicin (mainly Garlic)
2 doxorubicin
2 Astaxanthin
2 immunotherapy
2 Baicalin
2 Radiotherapy/Radiation
2 Betulinic acid
2 Vitamin B12
2 borneol
2 Cat’s Claw
2 chitosan
2 Ursolic acid
2 diet Short Term Fasting
2 Ferulic acid
2 Chemotherapy
2 Melatonin
2 Magnetic Field Rotating
2 Naringin
2 Oleocanthal
2 Phenylbutyrate
2 Sesame seeds and Oil
2 Selenite (Sodium)
2 Vitamin K2
1 2-DeoxyGlucose
1 Anthocyanins
1 entinostat
1 Paclitaxel
1 alpha Linolenic acid
1 Andrographis
1 Atorvastatin
1 Aloe anthraquinones
1 Biochanin A
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bacopa monnieri
1 brusatol
1 Carnosic acid
1 Caffeine
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carnosine
1 Cinnamon
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin -acetylsalicylic acid
1 Crocetin
1 Ginger/6-Shogaol/Gingerol
1 Ellagic acid
1 Evodiamine
1 Docetaxel
1 Exercise
1 Ascorbyl Palmitate
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 Orlistat
1 HydroxyTyrosol
1 Juglone
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Piperlongumine
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Rutin
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:309  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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