Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,
817- GAR,    Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways
- vitro+vivo, SCC, KYSE150 - vitro+vivo, SCC, KYSE450
HATs↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, CBP↓, p300↓, TGF-β↓, Ki-67↓, SMAD2↓, SMAD3↓,
818- GAR,  GB,    Garcinol Sensitizes NSCLC Cells to Standard Therapies by Regulating EMT-Modulating miRNAs
- in-vitro, Lung, A549
miR-205↑, Let-7↑, Apoptosis↑, miR-200b↑, miR-218↑,
819- GAR,    Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma
- in-vivo, GBM, U87MG - in-vitro, GBM, GBM
OCT4↓, SOX2↓, TumCG↓,
820- GAR,    Garcinol in gastrointestinal cancer prevention: recent advances and future prospects
- Review, NA, NA
Fas↑, TRAIL↑, PARP↑, BAX↑, Bcl-2↓, ROS↑, STAT3↓, Apoptosis↑, MMP2↓, MMP9↓,
821- GAR,    Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis
- in-vitro, Liver, Hep3B
ROS↑, CHOP/DDIT3↑, MMP↓, Bax:Bcl2↑, Casp8↑, Casp3↑, Casp9↑, cl‑PARP↑, DFF45↑,
822- GAR,    Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
- vitro+vivo, HNSCC, NA
ROS↑, STAT3↓, cSrc↓, JAK1↓, JAK2↓, NF-kB↓, TGF-β↓, TumCG↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
824- GAR,    Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
- in-vitro, NA, NA
AntiAg↓,
825- GAR,    Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling
- in-vitro, Pca, LNCaP - in-vitro, Pca, Bxpc-3 - in-vitro, Pca, PC3 - in-vitro, Pca, C4-2B
TumCG↓, Apoptosis↑, NF-kB↓,
796- GAR,    Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
- vitro+vivo, Pca, HeLa
HATs↓, PCAF↓, Apoptosis↑,
832- GAR,  Rad,    Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining
- in-vitro, Lung, A549 - in-vitro, NA, HeLa
HATs↓, other↑,
831- GAR,  CUR,    Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, Casp3↑, MMP↓, Cyt‑c↑, proCasp9↑, Bcl-2↓, BAX↑, PARP↓, DNAdam↑, DFF45↓,
830- GAR,    Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells
- in-vitro, CRC, HT-29
TumCI↓, TumCMig↓, Apoptosis↑, p‑FAK↓, Src↓, MAPK↓, ERK↓, PI3K/Akt↓, Bax:Bcl2↑, Cyt‑c↑, MMP7↓,
829- GAR,    The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma
- vitro+vivo, Melanoma, NA

828- GAR,  Cisplatin,    Garcinol Alone and in Combination With Cisplatin Affect Cellular Behavior and PI3K/AKT Protein Phosphorylation in Human Ovarian Cancer Cells
- in-vitro, Ovarian, OVCAR-3
tumCV↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, p‑PI3K↓, p‑Akt↓, NF-kB↓,
827- GAR,    Garcinol Is an HDAC11 Inhibitor
- in-vitro, NA, NA
HDAC11↓,
826- GAR,    Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
- vitro+vivo, HCC, HepG2 - vitro+vivo, Liver, HUH7
STAT3↓, TumCP↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, survivin↓, VEGF↓, TumCCA↑, TumVol↓,
793- GAR,    Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer
- in-vitro, SCC, SCC9 - in-vitro, SCC, SCC4 - in-vitro, SCC, SCC25
TumCG↓, Apoptosis↑, TumCCA↑, NF-kB↓, COX2/PTGS2↓, VEGF↓,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
795- GAR,    Garcinol—A Natural Histone Acetyltransferase Inhibitor and New Anti-Cancer Epigenetic Drug
- Review, NA, NA
HATs↓, BAX↑, PARP↑, Bcl-2↓, Casp3↑, Casp9↑, DR5↑, cFLIP↓, MMP2↓, MMP9↓, STAT3↓, p‑Akt↓,
797- GAR,  CUR,    Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
- in-vitro, BC, MCF7 - in-vitro, OS, U2OS - in-vitro, OS, SaOS2
TumCP↓, H3K18↓, DNAdam↑,
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7204- GAs,    The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba
- Review, Nor, NA
AntiTum↑, SUMO↓, antiNeop↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *toxicity↑, *ROS↑, *toxicity↝,
7214- GAs,    Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling
- vitro+vivo, NPC, CNE2
tumCV↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, PARP↑, Casp3↑, Casp9↑, TumCCA↑, CDK6↓, CycD3↓, ChemoSen↑,
7224- GAs,    Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,
7227- GAs,    Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports
- Review, Nor, NA
toxicity↑, other↝,
7233- GAs,    Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis
- in-vitro, Laryn, HEp2
TumCG↓, selectivity↑, Casp3↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, TumCP↓,
1187- GAs,    Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
- in-vitro, Melanoma, U251 - in-vitro, Melanoma, MM.1S
STAT3↓, PTEN↑, Apoptosis↑, PTPN6↑,
1186- GAs,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
1190- GBE,    Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model
- in-vivo, CRC, SW-620
TumMeta↑, Ki-67↑,
1189- GBE,    New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer
- Review, NA, NA
Apoptosis↑, TumCP↓, TumCI↓, TumCMig↓, Inflam↓, antiOx↑, angioG↓,
1188- GBE,    The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2-mediated antioxidant protection
- Review, Stroke, NA
*NRF2↑, *ROS↓, *Stroke↓,
7207- GBE,    The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review
- Review, AD, NA
*Inflam↓, *Apoptosis↓, *neuroP↑, *cardioP↑, *hepatoP↑, *AntiViral↑, *Bacteria↓, *RenoP↑, *ROS↓, *NADPH↓, *MAPK↓, *ERK↓, *JNK↓, *AP-1↓, *cAMP↑, *STAT5↓, *AMPK↑,
7197- GBE,    Ginkgo biloba for cognitive impairment and dementia
- Review, AD, NA
*cognitive↑, *toxicity↓,
7198- GBE,    Ginkgo biloba extract suppresses hepatocellular carcinoma progression by inhibiting the recruitment of myeloid-derived suppressor cells through reduced CXCL1 secretion via SRC downregulation
- vitro+vivo, HCC, NA
TumCG↓, Src↓, CXCL1↓, Dose↝,
7195- GBE,    Mitochondrial effects of Ginkgo biloba extract
- Review, AD, NA
*ROS↓, *mitResp↑, *AntiAge↑, *ATP↑, *neuroP↑, *ETC↑, *compI↑,
7187- GBE,    Ginkgo biloba for prevention of dementia: a randomized controlled trial
- Trial, AD, NA
*Dose↝, Risk∅, eff∅,
7205- GBE,    Exploring the multifaceted role of ginkgolides and bilobalide from Ginkgo biloba in mitigating metabolic disorders
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *ROS↓, *cardioP↑, *Obesity↓, *BioAv↓,
7206- GBE,  EGb 761,    Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer's Dementia: Clinical Trial Systematic Review
- Review, AD, NA
*Dose↝, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑,
7188- GBE,    Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trial
- Trial, AD, NA
*Dose↝, *cognitive↑,
7210- GBE,    Effectiveness and safety of ginkgo biloba preparations in the treatment of Alzheimer's disease: A systematic review and meta-analysis
- Review, AD, NA
*eff↑, *memory↑,
7211- GBE,    Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53
- in-vitro, CRC, HCT116
P53↑, MDM2↓, TumCD↓, tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Ferroptosis↑, ChemoSen↑,
7212- GBE,    The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *mitResp↑, *Casp9↓, *Casp3↓, *Apoptosis↓, *ATP↑, *neuroP↑, *IL1β↓, *IL6↓, *TNF-α↓, *PGE2↓, *memory↑, *cognitive↑, *BloodF↑, *lipid-P↓, *Aβ↓, *MAOA↓, *DA↑, *Dose↝, *toxicity↓,
7190- GBE,    Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis
- Review, Nor, NA
*AntiAg∅, *other∅,
7189- GBE,    Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect®Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx]
- Trial, NA, NA
*Dose↝, *toxicity↓,
1117- GBE,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CCN2/CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
4245- GBE,    Standardized extract of Ginkgo biloba enhances memory persistence over time
- in-vivo, AD, NA
*memory↑, *BDNF↑, *CREB↓, *BDNF↑,
4244- GBE,    Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men
- Human, Nor, NA
*BDNF∅,
7238- GBE,    Preventive effect of Ginkgo biloba extract (GBB) on the lipopolysaccharide-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2 via suppression of nuclear factor-kappaB in RAW 264.7 cells
- in-vitro, Nor, RAW264.7
*NO↓, *PGE2↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓,

Showing Research Papers: 4151 to 4200 of 8269
Prev Page 84 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SUMO↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   ROS↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,   c-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   FASN↓, 1,   lipoGen↓, 1,   PI3K/Akt↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 13,   BAX↑, 7,   Bax:Bcl2↑, 3,   Bcl-2↓, 8,   Bcl-xL↓, 1,   Casp3↓, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 4,   proCasp9↑, 1,   CBP↓, 1,   cFLIP↓, 3,   Cyt‑c↑, 3,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↑, 1,   MAPK↓, 1,   Mcl-1↓, 2,   MDM2↓, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 2,   TRAIL↑, 1,   TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   H3K18↓, 1,   HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   HATs↓, 4,   miR-205↑, 1,   miR-218↑, 1,   other↑, 1,   other↝, 2,   PCAF↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↓, 1,   DFF45↑, 1,   DNAdam↑, 2,   P53↑, 1,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   CycD3↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   Gli1↓, 1,   HDAC11↓, 1,   Let-7↑, 1,   NOTCH1↓, 1,   OCT4↓, 1,   p300↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,   PTPN6↑, 1,   SOX2↓, 1,   Src↓, 2,   STAT3↓, 5,   TumCG↓, 6,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   ATPase↓, 1,   CCN2/CTGF↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   p‑FAK↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   miR-200b↑, 1,   miR-200c↑, 1,   MMP1:TIMP1↑, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   PAI-1/SERPINE1↓, 1,   SMAD2↓, 2,   p‑SMAD2↓, 1,   SMAD3↓, 2,   p‑SMAD3↓, 1,   TGF-β↓, 3,   TIMP1↓, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 5,   TumMeta↑, 1,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCL1↓, 1,   CXCR4↓, 1,   Inflam↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff∅, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EZH2↓, 1,   HER2/EBBR2↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,   AntiTum↑, 1,   Risk∅, 1,   toxicity↑, 1,   TumVol↓, 1,   Wound Healing↓, 1,  
Total Targets: 130

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

DA↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   compI↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 5,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   ETC↑, 1,   mitResp↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cAMP↑, 1,   CREB↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other∅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   STAT5↓, 1,  

Migration(tgid=13) ⓘ

AntiAg∅, 1,   AP-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 4,   NF-kB↓, 1,   PGE2↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   BDNF∅, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Dose↝, 5,   eff↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 2,   cognitive↑, 4,   hepatoP↑, 1,   memory↑, 3,   neuroP↑, 5,   Obesity↓, 1,   RenoP↑, 1,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,  
Total Targets: 58

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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