Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7216- GBE,    Cytotoxic effect of Ginkgo biloba kernel extract on HCT116 and A2058 cancer cell lines
- in-vitro, Melanoma, A2058 - in-vitro, CRC, HCT116
tumCV↓, selectivity↑,
7215- GBE,  Cisplatin,    Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer
- vitro+vivo, NSCLC, NA
AntiCan↑, TumAuto↑, ChemoSen↑, Iron↑, lipid-P↑, Ferroptosis↑, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, ROS↑, NRF2↓, HO-1↓, MMP↓,
7226- GBE,    Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways
- vitro+vivo, Lung, NA
TumCP↓, selectivity↑, Apoptosis↑, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Fas↑, FasL↑, Dose↝, TumCG↓,
7223- GBE,    Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3K/Akt/NF- κ B/MMP-9 Signaling Pathway
- vitro+vivo, Melanoma, B16-F10
TumCP↓, TumCMig↓, p‑PI3K↓, p‑Akt↓, NF-kB↓, MMP9↓, TumMeta↓, Dose↝,
7234- GBE,    Ginkgo Biloba Extract Ameliorates Oxidative Phosphorylation Performance and Rescues Aβ-Induced Failure
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *OXPHOS↑, *OCR↑, *compI↓,
7218- GBE,    Efficacy and Safety of Ginkgo biloba in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
- Review, Stroke, NA
*Stroke↓, *eff↑, *toxicity↓, *other?,
3722- GBE,    Alzheimer's disease: Research summaries – Do Ginkgo products help?
- Review, AD, NA
*memory↑, *AntiAg↑,
3723- GBE,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
7670- GCL2505,    Effect of Continuous Ingestion of Bifidobacteria and Dietary Fiber on Improvement in Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial
- Trial, AD, NA
*cognitive↑, *GutMicro↑, *Inflam↓, *Dose↝, *BDNF∅,
790- Ge-132,    A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium)
- vitro+vivo, NA, NA
other↓, *toxicity↓,
791- Ge-132,    Germanium Sesquioxide Organic Germanium
other↝,
792- Ge-132,    The role of germanium in diseases: exploring its important biological effects
other↓,
789- Ge-132,    Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide
- Case Report, SCC, NA
Remission↑,
7132- Ge-132,    Organogermanium compound, Ge-132, forms complexes with adrenaline, ATP and other physiological cis-diol compounds
- in-vitro, Nor, NA
*other?,
7117- Ge-132,    Organogermanium suppresses cell death due to oxidative stress in normal human dermal fibroblasts
- in-vitro, Nor, NA
*IL6↓, *Apoptosis↓, *toxicity↓, Imm↑, IFN-γ↑, NK cell↑, AntiTum↑, Pain↓, *Wound Healing↑,
7131- Ge-132,    Antioxidant Activity of Ge-132, a Synthetic Organic Germanium, on Cultured Mammalian Cells
- in-vitro, Nor, CHO K1
*ROS↓,
7130- Ge-132,    Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer
- Trial, BC, NA
IL6↓, TumMeta↓, Dose↝, MCP1/CCL2↓,
7129- Ge-132,    Antitumor activity of Ge-132, a new organogermanium compound, in mice is expressed through the functions of macrophages and T lymphocytes
- in-vivo, lymphoma, NA
eff↑,
7128- Ge-132,    Pharmacokinetics of germanium after po beta-carboxyethylgermanium sesquioxide in 24 Chinese volunteers
- Trial, Nor, NA
*Half-Life↝,
7127- Ge-132,    Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents
- vitro+vivo, Var, NA
eff↑, BioAv↑, RadioS↑,
7126- Ge-132,    Immune activation of Bio-Germanium in a randomized, double-blind, placebo-controlled clinical trial with 130 human subjects: Therapeutic opportunities from new insights
- Trial, Nor, NA
AntiTum↑, AntiCan↑, *AntiAge↑, *AntiViral↑, *Inflam↓, *NK cell↑, *Imm↑, *TNF-α↑,
7125- Ge-132,    A review of public and environmental consequences of organic germanium
- Review, Nor, NA
*toxicity↓, other↝, Imm↑, anemia↓,
7124- Ge-132,    Physiological Activity of Trace Element Germanium including Anticancer Properties
- Review, Var, NA
*toxicity↓, Risk↓, Dose↝, AntiCan↑, AntiTum↑, Inflam↓, OXPHOS↝, *toxicity↓, *toxicity↓, other↑, eff↑, *Bacteria↓, *AntiFungal↑, eff↑, eff↑, ROS↑, eff↑, toxicity↝, *H2O2↓, *ROS↓, Warburg↓,
7133- Ge-132,    Organogermanium, Ge-132, promotes the clearance of senescent red blood cells via macrophage-mediated phagocyte activation
- in-vitro, Nor, RAW264.7
*RBC↑, *antiOx↑,
7101- Geld,    Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs
- in-vitro, Nor, NA
*toxicity↑, *AntiBio↑, HSP90↓, AntiCan↑,
7100- Geld,  Rad,    Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin
- in-vitro, Var, NA
HSP90↓, Akt↓, RadioS↑, selectivity↑,
7099- Geld,    Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation
- in-vitro, CRC, DLD1
RadioS↑, EF-1α↓, Akt↓, HSP90↓,
7098- Geld,    Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
- Review, Var, NA
HSP90↓, *toxicity↑, *toxicity↓, *BioAv↑, eff↑, *toxicity↓, other↝,
7097- Geld,    Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry
- Review, Var, NA
HSP90↓, *Bacteria↓, *toxicity↑,
7096- Geld,    A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues
- Study, Var, NA
HSP90↓, AntiTum↑,
7095- Geld,    Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
- Study, Var, NA
HSP90↓, selectivity↑,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
7109- GEN,    Single- and multiple-dose pharmacokinetics of genistein capsules in healthy chinese subjects: A phase I, randomized, open-label study
- Trial, Nor, NA
*Dose↝, *BioAv↝, *BioAv↝, *BioAv↝,
7106- GEN,  VitD3,    Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy
- Trial, Pca, NA
Dose↝, toxicity↓, VitD↑, AR↝,
7110- GEN,    Genistein
- Review, AD, NA
*toxicity↓, *Dose↝, *cognitive↑,
7107- GEN,    Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients
- Trial, Pca, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
COX2/PTGS2↓, P21↑, PGE2↓, other↑, Dose↝,
7105- GEN,    Effects of genistein supplementation on genome‑wide DNA methylation and gene expression in patients with localized prostate cancer
- Trial, Pca, NA
Risk↓, Myc↓, PTEN↑, Dose↝, NOTCH3↑, JAG1↑, ADCY4↑, NEU1↑,
7104- GEN,    Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial
- Trial, Pca, NA
Dose↝, PSA↓, *LDL↓,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, eff↑, ChemoSen↑,
28- GEN,    Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
- in-vivo, BC, MCF7
HH↓, Smo↓, Gli1↓, TumCG↓, TumCP↓, Apoptosis↑, CSCs↓,
29- GEN,    Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog-Gli1 pathway
- in-vivo, Pca, 22Rv1 - in-vivo, Pca, DU145
HH↓, Gli1↓, CSCs↓, TumCI↓, EMT↓, TumCG↓, CD44↓,
166- GEN,  EGCG,  RES,  CUR,    Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer
- in-vivo, Pca, NA
HH↓, Gli1↓,
927- GEN,  PacT,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioAv↑,
1504- GEN,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, P21↑, p16↑, ac‑H3↑, ac‑H4↑, TumCCA↑, Casp↑, Apoptosis↑, hTERT/TERT↓, BTG3↑,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
2997- GEN,    Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell
- in-vitro, Cerv, HeLa
TOP2↓, Sp1/3/4↓, Apoptosis↑, TumCCA↑,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,
7118- GEO2,    Germanium oxide inhibits the transition from G2 to M phase of CHO cells
- in-vitro, Ovarian, NA
TumCCA↑, CDK1↓,

Showing Research Papers: 4201 to 4250 of 8269
Prev Page 85 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ADCY4↑, 1,   anemia↓, 1,   JAG1↑, 1,   NEU1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH/GSSG↓, 1,   HO-1↓, 1,   Iron↑, 1,   lipid-P↑, 1,   NRF2↓, 1,   OXPHOS↝, 1,   ROS↑, 2,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 6,   Bax:Bcl2↑, 1,   BTG3↑, 1,   Casp↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 3,   IAP1↓, 1,   p‑JNK↑, 1,   Myc↓, 1,   p‑p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,   other↓, 2,   other↑, 2,   other↝, 4,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 7,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT3B↓, 1,   DNMTs↓, 2,   p16↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CycB/CCNB1↓, 1,   P21↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 2,   p‑cDC2↓, 1,   CSCs↓, 4,   EMT↓, 2,   p‑ERK↓, 1,   Gli1↓, 3,   HDAC↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HH↓, 3,   HMTs↓, 1,   KLF4↓, 1,   mTOR↓, 1,   NOTCH3↑, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,   Smo↓, 1,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MMP2↓, 1,   MMP9↓, 3,   PDGF↓, 1,   TIMP1↑, 1,   TumCI↓, 3,   TumCMig↓, 1,   TumCP↓, 5,   TumMeta↓, 3,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 1,   MCP1/CCL2↓, 1,   MyD88↑, 1,   NF-kB↓, 3,   NK cell↑, 1,   PGE2↓, 1,   PSA↓, 1,   TLR4↑, 1,   VitD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 3,   Dose↝, 8,   eff↑, 10,   Half-Life↑, 1,   MDR1↓, 1,   RadioS↑, 4,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   hTERT/TERT↓, 3,   IL6↓, 1,   Myc↓, 1,   PSA↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 4,   chemoPv↑, 1,   Pain↓, 1,   Remission↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 128

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   RBC↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   compI↓, 1,   GSH↑, 1,   H2O2↓, 1,   MDA↓, 1,   OXPHOS↑, 1,   ROS↓, 5,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↓, 1,   iNOS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   APP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL1β↑, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 5,   NF-kB↓, 1,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF∅, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   MAOB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 3,   Dose↝, 4,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 1,   cognitive↑, 3,   memory↑, 2,   neuroP↑, 2,   toxicity↓, 10,   toxicity↑, 4,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 3,   Bacteria↓, 4,  
Total Targets: 58

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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