Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7112- GEO2,    Hazard assessment of germanium supplements
- Review, Var, NA
toxicity↝, RenoP↓, NP/CIPN↑, Dose↝,
7113- GEO2,    Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide
- Review, Nor, NA
*Dose↓, *Dose↑, *toxicity↑, *creat↑, *Dose↑, *other?,
7116- GEO2,    Analytical product study of germanium-containing medicine by different ICP-MS applications
- Study, Nor, NA
*toxicity↓, *toxicity↑,
7119- GEO2,    Germanium oxide enhances the radiosensitivity of cells
- in-vitro, Nor, CHO K1
RadioS↑, ROS↑, eff↓, DNAdam↓, Catalase∅, GSTs∅,
7120- GEO2,    Germanium dioxide-induced nephropathy: a new type of renal disease
- Human, Var, NA
toxicity↑,
7121- GEO2,    Subacute nephrotoxicity of germanium dioxide in the experimental animal
- in-vivo, Nor, NA
toxicity↑, *creat↑, *BUN↑, *other↑,
7122- GEO2,    Nephrotoxicity of germanium compounds: report of a case and review of the literature
- Case Report, Var, NA
toxicity↑,
7123- GEO2,    Kinetics of germanium dioxide in rats
- in-vivo, Nor, NA
*Half-Life↝,
6566- Ger,  5-FU,    Geraniol, a Component of Plant Essential Oils, Sensitizes Human Colonic Cancer Cells to 5-Fluorouracil Treatment
- in-vitro, CRC, NA
TumCP↓, ChemoSen↑, other↝, EPR↑,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,
6562- Ger,    Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings
- Review, Var, NA - Review, AD, NA
*Inflam↓, *AntiCan↑, *AntiBio↑, *antiOx↑, *neuroP↑, ROS↓, Apoptosis↑, TumCCA↑, P53↝, STAT3↓, Casp↝, *Catalase↑, *GSTs↑, *GPx↑, *AChE↓, *GSH↑, *SOD↑, *TBARS↓, *NO↓, *XO↓, *memory↑, *IL1β↓, *iNOS↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *survivin↓, TumCP↓, TumCMig↓, TumCG↑, selectivity↑, TumMeta↓, angioG↓, Hif1a↓, Beclin-1/ATG6↓,
6563- Ger,  5-FU,    Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts
- vitro+vivo, Colon, SW-620 - in-vitro, Colon, Caco-2
TS↓, TK1↓, ChemoSen↑, TumVol↓, OS↑,
6564- Ger,    Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
- in-vitro, HCC, HepG2
TumCG↓, HMG-CoA↓, TumCP↓, eff↑, Dose↝,
6565- Ger,    Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest
- in-vitro, CRC, COLO205
AntiCan↑, mt-Apoptosis↑, BAX↑, Bcl-2↓, DNAdam↑, TumCCA↑,
6567- Ger,    Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- vitro+vivo, CRC, SW480 - in-vitro, CRC, HT29
AntiTum↑, *Inflam↓, *antiOx↓, TumCP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, p‑PI3K↓, p‑Akt↓, Dose↝, TumCG↓,
6568- Ger,    Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells
- in-vitro, Colon, Caco-2
HMG-CoA↓, MMP↓, PKCδ↓, ERK↓,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
6570- Ger,    Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells
- in-vitro, Thyroid, TPC-1
*Inflam↓, AntiCan↑, *neuroP↑, tumCV↓, TumCP↓, ROS↑, Apoptosis?, MMP↓, Bcl-2↓, cycD1/CCND1↓, cMyc↓, COX2/PTGS2↓, TNF-α↓, NF-kB↓, IL6↓, survivin↓, BAX↑, Casp3↑, JAK2↓, STAT3↓, ERK↓,
6571- Ger,    Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management
- Review, Obesity, NA
*lipidLev↓, *antiOx↓, Inflam↓, *ROS↓, *BioAv↑, *AntiDiabetic↑, *Obesity↓,
6573- Ger,    Systematic elucidation of the mechanism of geraniol via network pharmacology
- Study, Nor, NA - Study, Var, NA
HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,
7115- GeS,    A phase II study of spirogermanium as second line therapy in patients with poor prognosis lymphoma. An NCI Canada Clinical Trials Group Study
- Trial, lymphoma, NA
eff↓, toxicity↝,
7114- GeS,    A phase II study of spirogermanium in advanced human malignancy
- Human, Var, NA
*toxicity↝,
7201- GGB,    Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway
- vitro+vivo, GC, AGS - in-vitro, GC, HGC27
TumCI↓, TumCMig↓, Apoptosis↑, Pyro↑, BAX↑, GSDMD↑, Bcl-2↓, TumCG↓, EMT↓, PCNA↓, N-cadherin↓, E-cadherin↑, PI3K↓, Akt↓, mTOR↓, Dose↝,
7199- GGB,    Ginkgolide B Promotes Angiogenesis After Oxygen-Glucose Deprivation by Regulating AKT1 in bEnd.3 Cells
- in-vitro, Stroke, NA
*neuroP↑, *VEGF↑, *AKT1↑, *angioG↑, *Stroke↓,
7268- GGB,    Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42
- in-vitro, AD, NA
*PGE2↓, *Casp3↓, *neuroP↑, *PAF↑,
7269- GGB,    Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease
- in-vivo, AD, NA
*Inflam↓, *cognitive↑, *NLRP3↓, *neuroP↑,
7270- GGB,    Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor
- NA, AD, NA
*BDNF↑, *Apoptosis↓, *neuroP↑,
7271- GGB,    Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway
- in-vitro, Oral, NA
PAF↓, ChemoSen↑, Apoptosis↑,
7272- GGB,    Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p
- in-vitro, Bladder, NA
Zeb1↓, TumCI↓, miR-223-3p↓,
7273- GGB,    Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway
- vitro+vivo, Ovarian, NA
PAF↓, CSCs↓,
7274- GGB,    The potential immunotherapy effect of Ginkgolide B thwarts oral squamous cell carcinoma progression by targeting the SREBP1/KLK8/CCL22 axis
- vitro+vivo, Oral, KYSE-510 - in-vitro, Oral, TE1
lipid-P↝, TumCP↓, TumCMig↓, SREBP1/SREBF1↓, other↝,
7275- GGB,    Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota
- in-vivo, AD, NA
*cognitive↑, *neuroP↑, *RAGE↓, *BAX↓, *Bcl-2↑, *GutMicro↑,
7276- GGB,    Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs
- in-vivo, Nor, NA
*Dose↝, *BioAv↑, *Dose↝,
7277- GGB,    Ginkgolide B inhibits hydrogen peroxide-induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells
- in-vitro, Nor, H9c2
*cardioP↑, *Bcl-2↑, *cl‑Casp3↓, *BAX↓, *PI3K↑, *Akt↑, *mTOR↑,
7278- GGB,    Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *BDNF↑, *cognitive↑, *memory↑,
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,
7291- GGB,    Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora
- in-vivo, Nor, NA
BioAv↑, eff↑,
7294- GGB,    Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4
- vitro+vivo, GC, NA
angioG↓, GLUT1↓, GLUT4↓,
7293- GGB,    Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells
- in-vitro, AML, NA
TumCG↓, Apoptosis↑, mt-ROS↑,
7289- GGB,    The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
- Review, Var, NA
ORR↑, ChemoSen↑, OS↑, Weight↓, VEGF↑,
7286- GGB,    Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
Hif1a↓, Glycolysis↓, OXPHOS↑, ROS↑, Apoptosis↑, toxicity↓, PDKs↓, HK2↓, LDHA↓, PFKFB2↓, PKM2↓, eff↑,
7287- GGB,  Rad,    Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, TumCMig↓, RadioS↑, TumCCA↑, PI3K↓, p‑Akt↓, PDK1 / PDPK1↓,
7288- GGB,    Anti-Angiogenic Properties of Ginsenoside Rg3 Epimers: In Vitro Assessment of Single and Combination Treatments
- in-vitro, BC, MDA-MB-231
TumCMig↓, TumCP↓, Apoptosis↑, VEGF↓, AQPs↓, Akt↓, p‑mTOR↓, eff↑,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,
7221- GGB,  GEM,    Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway
- in-vitro, PC, NA
eff↑, NF-kB↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *eff↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *BioAv↑,
7142- GI,    Phase II study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer
- Trial, Nor, NA
COX2/PTGS2↓, *PGE2↓, *5-HETE↓, *12-HETE↓, *Eic↓, *AntiCan↑, *antiOx↑, *Inflam↓, 5LO↓, eff↝,
7143- GI,  Chemo,    Effect of a Standardized Ginger Root Powder Regimen on Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Double-Blind, Placebo-Controlled Randomized Trial
- Trial, Var, NA
Dose↝, chemoPv↑, Nausea↓, Vomit↓, mal↓, QoL↑,
7144- GI,  Cisplatin,    A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high-dose cisplatin
- Trial, Var, NA
Dose↝, Nausea∅, Vomit∅,
7145- GI,  Chemo,    Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study
- Trial, BC, NA
Dose↝, toxicity∅, Nausea∅, Vomit∅,

Showing Research Papers: 4251 to 4300 of 8269
Prev Page 86 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

mal↓, 1,   miR-223-3p↓, 1,   Nausea↓, 1,   Nausea∅, 2,   ORR↑, 1,   PAF↓, 2,   Vomit↓, 1,   Vomit∅, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase∅, 1,   GSH↓, 1,   GSTs∅, 1,   HO-1↝, 1,   lipid-P↝, 1,   OXPHOS↑, 1,   ROS↓, 1,   ROS↑, 4,   mt-ROS↑, 1,   SOD↓, 1,   TBARS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   HMG-CoA↓, 2,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,   PDKs↓, 1,   PFKFB2↓, 1,   PKM2↓, 1,   SREBP1/SREBF1↓, 1,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 2,   Apoptosis?, 1,   Apoptosis↑, 8,   mt-Apoptosis↑, 1,   BAX↑, 6,   Bcl-2↓, 5,   Casp↝, 1,   Casp3↑, 4,   Casp8↑, 1,   Casp9↑, 3,   GSDMD↑, 1,   Pyro↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 2,   P53↑, 1,   P53↝, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 1,   ERK↓, 2,   HRAS↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   STAT3↓, 2,   TK1↓, 1,   TumCG↓, 4,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   TumCI↓, 3,   TumCMig↓, 6,   TumCP↓, 8,   TumMeta↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EPR↑, 1,   Hif1a↓, 2,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↑, 1,   GLUT1↓, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL6↓, 1,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 3,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 4,   Dose↝, 7,   eff↓, 2,   eff↑, 5,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoPv↑, 1,   NP/CIPN↑, 1,   OS↑, 2,   QoL↑, 1,   RenoP↓, 1,   toxicity↓, 1,   toxicity↑, 3,   toxicity↝, 2,   toxicity∅, 1,   TumVol↓, 1,   Weight↓, 1,  
Total Targets: 117

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   5-HETE↓, 1,   AntiBio↑, 1,   Eic↓, 1,   PAF↓, 1,   PAF↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 4,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 1,   TBARS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↑, 1,   BUN↑, 1,   lipidLev↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 3,   Bcl-2↑, 3,   Casp3↓, 1,   cl‑Casp3↓, 2,   Cyt‑c↓, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Mst1↓, 1,   mTOR↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   RAGE↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   IL8↓, 1,   Inflam↓, 7,   MyD88↓, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,   XO↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   BioAv↝, 1,   Dose↓, 1,   Dose↑, 2,   Dose↝, 2,   eff↓, 2,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

creat↑, 2,   GutMicro↑, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 4,   memory↑, 2,   neuroP↑, 9,   Obesity↓, 1,   radioP↑, 1,   toxicity↓, 1,   toxicity↑, 2,   toxicity↝, 1,  
Total Targets: 80

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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