Cancer Database Query Results

Scientific Papers found: Click to Expand⟱

Gos,

-(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro

ChemoSen↑, Bcl-2↓, Mcl-1↓, BIM↑, PUMA↑,

Gos,

A phase II study of AT-101 (gossypol) in chemotherapy-sensitive recurrent extensive stage small cell lung cancer (ES-SCLC)

Trial,

Lung,

Bcl-2↓, Bcl-xL↓, Mcl-1↓, NOXA↑, PUMA↑, Dose↝, eff↓,

7316-

Gos,

PacT,

carbop,

Chemo,

A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors

Trial,

Var,

Twenty-four patients

Bcl-2↓, Bcl-xL↓, Mcl-1↓, Dose↝, toxicity↝,

7315-

Gos,

Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells

vitro+vivo,

CRC,

HT29

in-vitro,

CRC,

COLO205

TumCD↑, Casp3↑, Casp6↑, Casp8↑, Casp9↑, cl‑PARP↑, Bcl-xL↓, ROS↑, i-H2O2↑, eff↓, mtDam↑, MMP↓, Cyt‑c↑, AIF↑, TumCG↓,

7313-

Gos,

Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

in-vitro,

Lung,

H460

selectivity↑, eff↑,

7312-

Gos,

A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum

vitro+vivo,

Pca,

PC3

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

eff↑, TumAuto↑, TumCG↓, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Apoptosis↑, eff↑,

7311-

Gos,

Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials

Review,

CLL,

A total of 17 trials involving 759 patients met the inclusion criteria.

Dose↝, toxicity↓, PFS↓, OS↑, eff↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,

7310-

Gos,

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

in-vitro,

AML,

TumCD↑, MOMP↑, ROS↑, ATP↓, BAX↑, Cyt‑c↑, AIF↑,

7309-

Gos,

Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa

vitro+vivo,

Pca,

PC3

PC-3 xenograft model in nude mouse.

Bcl-2↓, Bcl-xL↓, Mcl-1↓, TumCG↓, Apoptosis↓, ChemoSen↑,

7314-

Gos,

The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro

in-vitro,

Melanoma,

A375

Dose↝, ROS↑, selectivity↑, Half-Life↓, MMP↓, BioAv↑,

941-

Gos,

Rad,

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis

in-vivo,

NA,

mice, injection to mice starting at week 4 postirradiation at a dose of 5 mg/kg in 30 μl volume

lactateProd↓, other↓, TGF-β↓,

845-

Gra,

A Review on Annona muricata and Its Anticancer Activity

Review,

NA,

GlucoseCon↓, ATP↓, HIF-1↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ERK↓, Akt↓, Apoptosis↑, NF-kB↓, ROS↑, Bax:Bcl2↑, MMP↓, Casp3↑, Casp9↑, p‑JNK↓,

844-

Gra,

Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells

in-vitro,

BC,

MDA-MB-231

0-200ug/mL

in-vitro,

BC,

MCF7

tumCV↓, TumCI↓, ROS↑,

843-

Gra,

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

in-vitro,

NMSC,

A431

3.5 µg/mL

DCM fraction proved to be by far the most potent in inhibiting the proliferation

in-vitro,

NMSC,

UW-BCC1

4.0 µg/mL

in-vitro,

Nor,

NHEKn

38.8 µg/mL

10-fold higher than in noncancerous NHEKn cells

TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,

842-

Gra,

Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)

in-vitro,

NA,

200-335ug/mL

in-vitro,

Nor,

no cytotoxic effect

no cytotoxic effect on normal spleen cells

other↓, *toxicity↓,

841-

Gra,

The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach

in-vitro,

CRC,

HT-29

1.62ug/ml@48hr

in-vitro,

Nor,

CCD841

32.51μg/ml@48 h

normal human colon cells

PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,

840-

Gra,

Evaluation of cytotoxicity of aqueous extract of Graviola leaves on squamous cell carcinoma cell-25 cell lines by 3-(4,5-dimethylthiazol-2-Yl) -2,5-diphenyltetrazolium bromide assay and determination of percentage of cell inhibition at G2M phase of cell cycle by flow cytometry: An in vitro study

in-vitro,

SCC,

SCC25

TumCCA↑, ATP↓,

839-

Gra,

Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway

in-vitro,

Liver,

HepG2

tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP/DDIT3↑,

838-

Gra,

Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes

in-vitro,

Pca,

BPH1

1.36 mg/mL

BPH cells and rats

BAX↑, Bcl-2↓, TumVol↓,

837-

Gra,

Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines

in-vitro,

BC,

MDA-MB-435

29.2 μg

in-vitro,

Nor,

WRL68

52.4 μg

in-vitro,

Nor,

HaCaT

30.1 μg

human immortalized keratinocyte cells

*toxicity↓,

836-

Gra,

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism

vitro+vivo,

PC,

mice

Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,

835-

Gra,

Annona muricata leaves induced apoptosis in A549 cells through mitochondrial-mediated pathway and involvement of NF-κB

in-vitro,

Lung,

A549

5ug/mL @72hr

ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp9↑, Casp3↑, Apoptosis↑, TumCCA↑,

834-

Gra,

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Review,

NA,

EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,

833-

Gra,

Cytotoxic Effect of Annona muricata leaf extracts on tumor cell lines in vitro

in-vitro,

BC,

MDA-MB-231

134.6 mg/ml

in-vitro,

Lung,

A549

124.6 mg/ml

Apoptosis↑,

847-

Gra,

Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).

NADHdeh↓,

858-

Gra,

Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells

in-vitro,

CRC,

HT-29

11.43 µg/ml

in-vitro,

CRC,

HCT116

8.98 µg/ml

TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,

857-

Gra,

The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line

in-vitro,

CRC,

COLO205

Casp3↑, tumCV↓,

856-

Gra,

https://pubmed.ncbi.nlm.nih.gov/33048613/

in-vitro,

BC,

MCF7

85.55 µg/mL

TumCCA↑, ROS↑, Casp↑,

855-

Gra,

Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques

in-vitro,

BC,

MCF7

 4.75 μg/mL

TumCG↓, TumCP↓, TumCCA↑, Apoptosis↑,

854-

Gra,

AgNPs,

Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy

vitro+vivo,

AML,

THP1

17.34 µg/mL

in-vitro,

AML,

AMJ13

vitro+vivo,

lymphoma,

HBL

TumCP↓, TumAuto↑, IL1↓, NLRP3↓, Apoptosis↑, mtDam↑, P53↑, LDH↓,

853-

Gra,

AgNPs,

Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies

other↑,

852-

Gra,

Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

in-vitro,

BC,

MCF7

2-3ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Colon,

HCT116

2ug/mL

AgNPs-PE, AgNPs-LE

in-vitro,

Melanoma,

A375

3-8ug/mL

AgNPs-PE, AgNPs-LE

tumCV↓,

851-

Gra,

Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF7

f 5.3, 2.86, 3.08, and 48.31 µg/mL

ethanol extract, ethyl acetate, n-hexane, and water fractions of A. muricata leaves

in-vitro,

Nor,

CV1

Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,

850-

Gra,

Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin

in-vitro,

PC,

PC3

0.1uM(Annonacin) 55ug/mL(EAB)

without impacting RWPE-1 normal prostate cells

in-vitro,

Pca,

DU145

ROS∅, MMP∅, Casp3↑, Casp7↑, VEGF↓,

849-

Gra,

Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis

in-vitro,

Pca,

PC3

 48.17μg/ml

in-vitro,

Nor,

PNT1A

7.8x higher

normal health cells

in-vitro,

NA,

HeLa

Casp9↑, CXCL1↓, *toxicity↓,

848-

Gra,

AgNPs,

Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles

in-vitro,

CRC,

HCT116

ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,

846-

Gra,

Cytotoxic effect of Annona muricata Linn leaves extract on Capan-1 cells

in-vitro,

NA,

Ca9-22

IC25 varied ~7.8-8μg/ml and ~0.9-1.0μg/ml respectively.

other↑,

1234-

Gra,

Graviola attenuates DMBA-induced breast cancer possibly through augmenting apoptosis and antioxidant pathway and downregulating estrogen receptors

in-vivo,

BC,

200 mg/kg body mass

rats

Apoptosis↑, BAX↑, P53↑, Casp3↑, ER-α36↓, lipid-P↓,

1233-

Gra,

THERAPEUTIC ELIGIBILITY OF GRAVIOLA VERSUS 5-FLUOROURACIL: APOPTOTIC EFFICACY ON HEAD AND NECK SQUAMOUS CELL CARCINOMA AND NORMAL EPITHELIUM CELLS

in-vitro,

HNSCC,

(200 μg/ml, 400 μg/ml, 600 μg/ml, 800 μg/ml, and 1000 μg/m

103ug/ml @48hr

Apoptosis↑, MMP↓,

1232-

Gra,

Graviola: A Systematic Review on Its Anticancer Properties

Review,

NA,

oral 100mg/kg

EGFR↓, cycD1/CCND1↓, Bcl-2↓, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, BAX↑, Cyt‑c↑, Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, ATP↓,

2437-

Gra,

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

in-vitro,

Pca,

LNCaP

1–5 μg/ml

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

PC3

in-vitro,

Nor,

PWR-1E

NOX↓, selectivity↑,

2438-

Gra,

Emerging therapeutic potential of graviola and its constituents in cancers

Review,

Var,

Hif1a↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, MUC4↓, TumCCA↑, MMP↓, NF-kB↓, ROS↓, Bax:Bcl2↑, ER(estro)↓, cycD1/CCND1↓, chemoPv↑, hepatoP↑,

7338-

Gra,

Pharmacological Activities of Soursop (Annona muricata Lin.)

Review,

Var,

AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,

7337-

Gra,

Synergistic interactions among flavonoids and acetogenins in Graviola (Annona muricata) leaves confer protection against prostate cancer

in-vitro,

Pca,

other↝, eff↝, BioAv↝, TumCD↓, TumCG↓, Dose↝, other↝,

7336-

Gra,

In Vitro Evaluation of Annona muricata Leaf Infusion as a Modulator of Antineoplastic Drug-Induced Cytotoxicity in Cancer Cell Lines

in-vitro,

BC,

MDA-MB-231

ChemoSen↑, selectivity↑,

7335-

Gra,

Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review

Review,

Var,

TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,

7334-

Gra,

Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism

in-vivo,

Park,

*other↑, *cognitive↓, *Risk↑,

7332-

GSE,

The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials

Review,

Nor,

16 clinical trials and 810 study subjects were analyzed.

*BP↓, *eff↑, *ROS↓, *DNAdam↓, *cardioP↑, *eff↝,

7333-

GSE,

The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis

Review,

Nor,

 Nineteen trials were included in this study.

*BP↓,

7331-

GSE,

Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract

in-vivo,

Nor,

 (MOCAP)-induced neurotoxicity in mice.

*ROS↓, TumCD↑, *RenoP↑,

Showing Research Papers: 4401 to 4450 of 8269
Prev Page 89 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1, GSH↑, 1, MDA↓, 2, ROS↓, 3, SOD↑, 1,

Cell Death(tgid=5) ⓘ

BAX↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

PGE2↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1, eff↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 2,

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1, cardioP↑, 1, cognitive↓, 1, RenoP↑, 1, Risk↑, 1, toxicity↓, 6, Wound Healing↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1, Bacteria↓, 1, Diar↓, 1,
Total Targets: 24

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Cancer Database Query Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

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