Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
5732- Buty,    GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon
- Study, CRC, NA
HCAR2↑, other↓, Apoptosis↑, HDAC↓, Bcl-2↓, Bcl-xL↓, cycD1/CCND1↓, DR5↑, NF-kB↓, GutMicro↑, SLC12A5↝,
1207- CA,  PacT,    Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa
TumCG↑, TumCMig↓, Apoptosis↓, ac‑α-tubulin↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
1297- CA,    Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
- in-vitro, Ovarian, OV7
lysosome↓, Apoptosis↑, Bax:Bcl2↑,
7514- CA,    Selective toxicity of caffeic acid in hepatocellular carcinoma cells
- in-vitro, HCC, NA
TumCP↓, Apoptosis↑,
5750- CA,    Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells
- in-vitro, MM, NA
eff↑, selectivity↑, Ki-67↓, PCNA↓, TumCP↓, p‑ERK↓, Akt↓, p27/CDKN1B↑, P21↑, TumCCA↑, Bax:Bcl2↑, cl‑Casp3↑, mt-Apoptosis↑,
5747- CA,    Caffeic Acid Enhances Anticancer Drug-induced Apoptosis in Acid-adapted HCT116 Colon Cancer Cells
- in-vitro, CRC, NA
TumCP↓, Apoptosis↑, ChemoSen↑, PI3K↓, Akt↓, ERK↓,
5746- CA,    Caffeic acid hinders the proliferation and migration through inhibition of IL-6 mediated JAK-STAT-3 signaling axis in human prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
tumCV↓, ROS↑, TumCCA↑, Apoptosis↑, p‑MAPK↓, ERK↓, JNK↓, p38↓, IL6↓, JAK1↓, p‑STAT3↓, cycD1/CCND1↓, CDK1↓, BAX↑, Casp3↑, Bcl-2↓, TumCD↑,
5877- CA,    Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↑, Casp9↑, Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↓, MDM2↓, ROS↑, eff↓, STAT3↓, survivin↓, cycD1/CCND1↓,
5866- CA,    Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480 - in-vitro, Colon, HT29
tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
5869- CA,    Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
- in-vitro, ESCC, KYSE150
TumCP↓, Apoptosis↓, TumCMig↓, TumCCA↑, DNAdam↑, MAPK↓, γH2AX↑, TumMeta↓, TumCI↓, P21↑, ROS↑, EMT↓, ChemoSen↑,
5870- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF7
ROS↑, cJun↑, p38↑, eff↓, TumCP↓, glucose↓, Apoptosis↑, BAX↑, PARP↑, Bcl-2↓, TumCG↑, Ki-67↓, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5876- CA,    Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells
- in-vitro, neuroblastoma, NA
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, Bcl-2↓, ROS↑, eff↓,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, eff↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,
5835- CAP,    Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+-mediated mitochondrial pathway
- in-vitro, GBM, U251
tumCV↓, Apoptosis↑, selectivity↑, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Casp↑, eff↑, MPT↑, ETC↓, Casp3↑, Casp9↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5832- CAP,    Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
- in-vitro, Oral, KB
TumCP↓, tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, Casp9↑, Casp3↑, PARP↑, Inflam↓, Pain↓,
5831- CAP,    Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
TRPV1↑, Ca+2↑, AntiCan↑, TumCP↓, Pain↓, TumCG↓, ChemoSen↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5826- CAP,    Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload
- in-vitro, Thyroid, NA
TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5856- CAP,    Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumAuto↑, angioG↓, TumCG↓, TumMeta↓, P-gp/ABCB1↝, ERK↝, NF-kB↝, STAT3↝, eff↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5848- CAP,  SRF,    Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
ChemoSen↑, Apoptosis↑, Casp9↑, PARP↑, Akt↓, AMPK↑, p‑ACC↑,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5843- CAP,    The Effects of Capsaicin on Gastrointestinal Cancers
- Review, GC, NA
*BioAv↑, ROS↑, Apoptosis↑, Glycolysis↓, HK2↓, MMP9↓, AMPK↑, TumCP↓, Casp3↑, Bcl-2↓, P53↑, BAX↑,
5203- CAP,    Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells
- in-vitro, OS, KB
tumCV↓, TNF-α↓, NF-kB↓, selectivity↑, Apoptosis↑, TumCMig↓,
5201- CAP,    Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells
- NA, HCC, HepG2
AntiCan↓, Apoptosis↑, cl‑PARP↑, Bcl-2↑, TumAuto↑, LC3II↑, eff↑, STAT3↑, ROS↑, eff↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
5199- CAP,    Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
- vitro+vivo, AML, NA
STAT3↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, VEGF↓, TumCCA↑, Apoptosis↑, Casp↑, eff↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
2012- CAP,    Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways
- NA, OS, MG63
AntiTum↑, Apoptosis↑, TRPV1↑, ROS↑, SOD↓, AMPK↑, P53↑, JNK↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑PARP↑, Ca+2↑, MMP↓,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5764- CAPE,    Caffeic Acid Phenethyl Ester (CAPE), Derived from a Honeybee Product Propolis, Exhibits a Diversity of Anti-tumor Effects in Preclinical Models of Human Breast Cancer
- vitro+vivo, BC, MCF7 - NA, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, NF-kB↓, MDR1↓, VEGF↓, angioG↓,
5762- CAPE,    Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy
- in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
ChemoSen↓, Apoptosis↑,
7520- CAPE,    Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5882- CAR,    Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, pRB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, PI3K↓, p‑Akt↓, Apoptosis↑, Bcl-2↓, BAX↑,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,

Showing Research Papers: 401 to 450 of 1808
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1808

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GFAP↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   compI↓, 1,   GPx↓, 2,   GSH↓, 2,   GSH/GSSG↓, 1,   MDA↓, 1,   MDA↑, 1,   NADH↓, 2,   RNS↑, 1,   ROS↑, 31,   mt-ROS↑, 1,   SOD↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   compIII↓, 1,   ETC↓, 1,   MEK↓, 1,   MMP↓, 15,   MMP↑, 2,   MPT↑, 3,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑ACC↑, 1,   ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 6,   cMyc↓, 1,   FASN↓, 1,   FBI-1↓, 1,   GLS↓, 1,   glucose↓, 2,   Glycolysis↓, 2,   HK2↓, 2,   LDH↓, 1,   LDH↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PDH↓, 1,   PFK↓, 1,   PKM2↓, 1,   SIRT1↓, 4,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   p‑Akt↓, 1,   Apoptosis↓, 4,   Apoptosis↑, 43,   mt-Apoptosis↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 13,   Bax:Bcl2↑, 5,   Bcl-2↓, 18,   Bcl-2↑, 1,   Bcl-xL↓, 4,   Casp↑, 10,   Casp3↓, 1,   Casp3↑, 15,   cl‑Casp3↑, 2,   Casp9↑, 8,   Cyt‑c↑, 12,   DR5↑, 1,   Fap1↓, 1,   Fas↑, 2,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 5,   p‑JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   p‑MAPK↓, 1,   MDM2↓, 2,   p27/CDKN1B↑, 1,   p38↓, 1,   p38↑, 2,   p‑p38↑, 2,   survivin↓, 5,   TRPV1↑, 7,   TumCD↑, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   other↓, 2,   pRB↓, 1,   tumCV↓, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 1,   ER Stress↑, 2,   GRP78/BiP↓, 1,   IRE1↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   LC3II↑, 3,   lysosome↓, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   P53↓, 1,   P53↑, 8,   PARP↑, 5,   cl‑PARP↑, 7,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 5,   CDK4↑, 1,   cycD1/CCND1↓, 8,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 4,   RB1↑, 1,   TumCCA↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 2,   ERK↓, 3,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 2,   FOXO3↑, 1,   HDAC↓, 1,   mTOR↓, 4,   NOTCH↓, 1,   PI3K↓, 8,   PI3K↑, 1,   STAT3↓, 7,   STAT3↑, 1,   STAT3↝, 1,   p‑STAT3↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TRPM7↓, 2,   TumCG↓, 7,   TumCG↑, 2,  

Migration(tgid=13) ⓘ

AXL↓, 1,   Ca+2↑, 10,   i-Ca+2?, 1,   p‑Cofilin↑, 1,   E-cadherin↑, 2,   F-actin↓, 2,   Ki-67↓, 4,   MMP2↓, 7,   MMP9↓, 8,   MMPs↓, 1,   Snail↓, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCA↓, 1,   TumCI↓, 2,   TumCMig↓, 9,   TumCP↓, 12,   TumCP↑, 1,   TumMeta↓, 5,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   ac‑α-tubulin↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   Hif1a↓, 2,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT3↓, 1,   P-gp/ABCB1↝, 1,   SLC12A5↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HCAR2↑, 1,   IL6↓, 2,   Inflam↓, 1,   JAK1↓, 1,   NF-kB↓, 4,   NF-kB↝, 1,   PD-L1↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1,   CDK6↓, 3,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 9,   Dose↝, 2,   Dose∅, 1,   eff↓, 11,   eff↑, 21,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MDR1↓, 1,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   AR↑, 1,   GutMicro↑, 1,   IL6↓, 2,   Ki-67↓, 4,   LDH↓, 1,   LDH↑, 1,   PD-L1↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 2,   AntiCan↑, 2,   AntiDiabetic↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 7,   NDRG1↑, 1,   neuroP↑, 1,   Obesity↓, 1,   Pain↓, 2,   toxicity↓, 1,   toxicity↝, 1,   TumW↓, 1,   Weight↑, 2,  
Total Targets: 217

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 5,   ROS∅, 1,   SOD↑, 2,   UCPs↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   MMP↑, 1,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   LDH↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3∅, 1,   Cyt‑c∅, 1,   necrosis↓, 1,   TRPV1↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,   TRPM7↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 4,   Ca+2↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL18↓, 1,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 9,   NF-kB↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 2,   BP↓, 1,   GutMicro↑, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 3,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 3,   Obesity↓, 2,   Pain↓, 3,   RenoP↑, 1,   toxicity∅, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 64

Scientific Paper Hit Count for: Apoptosis, Apoptosis
69 Curcumin
67 Silver-NanoParticles
45 Magnetic Fields
44 Quercetin
36 Thymoquinone
34 Berberine
34 EGCG (Epigallocatechin Gallate)
32 Sulforaphane (mainly Broccoli)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Kaempferol
25 Shikonin
23 Betulinic acid
23 Honokiol
23 Phenethyl isothiocyanate
22 Radiotherapy/Radiation
22 Resveratrol
22 Licochalcone A
20 Garcinol
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Cisplatin
18 Dandelion Root
18 Lycopene
18 Urolithin
17 Gambogic Acid
17 Hyperoside
16 Chemotherapy
16 Emodin
16 Eugenol
16 Fisetin
16 Formononetin
15 chitosan
15 Carvacrol
15 Luteolin
15 Nimbolide
14 Astaxanthin
14 Crocetin
14 Ivermectin
13 Beta-Caryophyllene
13 salinomycin
13 Graviola
13 Magnolol
13 Indole-3-carbinol
12 Allicin (mainly Garlic)
12 Metformin
12 chaetocin
12 HydroxyTyrosol
12 Isobavachalcone
12 Juglone
12 Selenium NanoParticles
11 Paclitaxel/Taxol
11 Propolis -bee glue
11 Chlorogenic acid
11 Silymarin (Milk Thistle) silibinin
11 Dichloroacetate
11 Isoliquiritigenin
11 Isovitexin
10 isoquercitrin
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 doxorubicin
10 Fucoidan
10 Gallic acid
10 Ginkgetin
10 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 isoorientin
10 Phenylbutyrate
10 Piperlongumine
9 Photodynamic Therapy
9 5-fluorouracil
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Hydrogen Gas
9 Magnetic Field Rotating
9 Rosmarinic acid
8 Coenzyme Q10
8 Auranofin
8 Gemcitabine (Gemzar)
8 Bufalin/Huachansu
8 Caffeic acid
8 Citric Acid
8 Carvone
8 Cynara scolymus/Globe Artichoke/Artichoke Extract
8 Electrical Pulses
8 Ursolic acid
8 Cynaropicrin
8 Ginkgolide B
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Carnosic acid
7 Cinnamon
7 Deguelin
7 Lemongrass Extract/Citral
7 Genistein (soy isoflavone)
7 Evodiamine
7 Vitamin K2
6 Astragalus
6 Fenbendazole
6 Andrographis
6 Celecoxib
6 D-limonene
6 Disulfiram
6 Ellagic acid
6 Echinacea
6 Ferulic acid
6 Ginkgo biloba
6 Hibiscus sabdariffa
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 3-bromopyruvate
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Diclofenac
5 Aflavin-3,3′-digallate
5 iodine
5 Vitexin
5 Lactoferrin/Talactoferrin
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 Rutin
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Centella asiatica / Gotu kola → asiaticoside
4 Dichloroacetophenone(2,2-)
4 Ginkgo biloba-EGb 761
4 Eurycomanone
4 Galloflavin
4 Geraniol
4 Ginger/6-Shogaol/Gingerol
4 γ-linolenic acid (Borage Oil)
4 Gossypol/AT-101
4 itraconazole
4 Lasiodin
4 Licorice
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 Aspirin
3 Dipyridamole
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cat’s Claw
3 Cannabidiol
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Ginkgolic acids
3 Grapeseed extract
3 HydroxyCitric Acid
3 Orlistat
3 Hyperthermia
3 Inositol
3 isoflavones
3 Lapachol
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Sorafenib (brand name Nexavar)
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Bullatacin
2 Chocolate
2 Hydroxycinnamic-acid
2 irinotecan
2 Polyphenols
2 CUSP9
2 gefitinib, erlotinib
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 eicosapentaenoic acid
2 Shilajit/Fulvic Acid
2 hydrogen sulfide
2 Helleborus niger extracts – Christmas Rose
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 methotrexate
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 Dihydrocaffeic Acid
1 methylseleninic acid
1 diet Methionine-Restricted Diet
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Cannabichromene
1 Tetrahydroxystilbene glucoside
1 Exercise
1 ferumoxytol
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 carboplatin
1 olaparib/LYNPARZA
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginseng
1 Rapamycin
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 Huperzine A/Huperzia serrata
1 Inoscavin A
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Mung Bean Sprouts
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 Phenolic Acids
1 Rhein
1 Rauwolfia serpentina/Indian Snakeroot
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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