MMP Cancer Research Results

MMP, ΔΨm, mitochondrial membrane potential: Click to Expand ⟱
Source:
Type:
Destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Mitochondria are organelles within eukaryotic cells that produce adenosine triphosphate (ATP), the main energy molecule used by the cell. For this reason, the mitochondrion is sometimes referred to as “the powerhouse of the cell”.
Mitochondria produce ATP through process of cellular respiration—specifically, aerobic respiration, which requires oxygen. The citric acid cycle, or Krebs cycle, takes place in the mitochondria.
The mitochondrial membrane potential is widely used in assessing mitochondrial function as it relates to the mitochondrial capacity of ATP generation by oxidative phosphorylation. The mitochondrial membrane potential is a reliable indicator of mitochondrial health.
In cancer cells, ΔΨm is often decreased, which can lead to changes in cellular metabolism, increased glycolysis, increased reactive oxygen species (ROS) production, and altered cell death pathways.

The membrane of malignant mitochondria is hyperpolarized (−220 mV) in comparison to their healthy counterparts (−160 mV), which facilitates the penetration of positively charged molecules to the cancer cells mitochondria.
The MMP is a critical indicator of mitochondrial function, directly reflecting the organelle's capacity to generate ATP through oxidative phosphorylation.


Scientific Papers found: Click to Expand⟱
1644- HCAs,  PBG,    Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis
- in-vitro, Pca, LNCaP
NF-kB↓, TRAILR↑, Casp8↑, Casp3↑, MMP↓, Dose?,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7356- HibSad,    Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,
7339- Hne,    Apoptosis-inducing activity of Helleborus niger in ALL and AML
- in-vitro, AML, NA
TumCP↓, DNAdam↓, Casp3↑, MMP↓, eff↑, Apoptosis↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2887- HNK,    Honokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming
- in-vitro, AD, BV2
*Glycolysis↑, *ATP↑, *ROS↓, *MMP↑, *OXPHOS↑, *PPARα↑, *PGC-1α↑,
2889- HNK,  doxoR,    Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
- in-vivo, Nor, NA
*SIRT3↑, chemoP↑, *cardioP↑, mtDam↑, ROS↑, *ROS↓, *MMP↑,
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, *antiOx↑, *AntiAge↑, *MMP↑, *ECAR↓, *Glycolysis↓, *PAR-2↓, *CXCL12↑, *BMAL1↑, *mt-ROS↓, *OXPHOS↓,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
886- HPT,    Impact of hyper- and hypothermia on cellular and whole-body physiology
- Analysis, NA, NA
MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,
7535- HT,    Hydroxytyrosol acetate from olive leaves (Olea Europaea L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line
- in-vitro, Liver, Bel-7402
TumCP↓, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Apoptosis↑,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
7557- HYP,    Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1-42
- in-vitro, AD, NA
*neuroP↑, *Aβ↓, *Casp3↑, *ZO-1↓, *CLDN5↓, *OCLN↓, *MMP2↑, *MMP↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7554- HYP,    Effect of hyperoside on the apoptosis of A549 human non‑small cell lung cancer cells and the underlying mechanism
- in-vitro, NSCLC, A549
tumCV↓, Apoptosis↑, p‑MAPK↑, JNK↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, AIF↑,
7612- I3C,    Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in nontumorigenic breast epithelial cells
- in-vitro, Nor, MCF10
selectivity↑, Bax:Bcl2↓, Bcl-xL↓, BAX↑, MMP↓, Cyt‑c↑, TumCD↑,
7584- I3C,    Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells
- in-vitro, Cerv, HeLa - in-vitro, CRC, HCT8 - in-vitro, Liver, HepG2
TumCP↓, Apoptosis↑, TumCI↓, *antiOx↑, AhR↑, MMP↓, Casp3↑, Casp8↑,
7586- I3C,    Bax translocation to mitochondria is an important event in inducing apoptotic cell death by indole-3-carbinol (I3C) treatment of breast cancer cells
- in-vitro, BC, NA
TumCG↓, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, TumCCA↑,
7591- I3C,    Indole-3-carbinol (I3C)-induced apoptosis in nasopharyngeal cancer cells through Fas/FasL and MAPK pathway
- in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, XIAP↓, IAP1↓, survivin↓, Diablo↑, Cyt‑c↑, HTRA2/Omi/PARK13↑, mtDam↑, Fas↑, FasL↑,
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,
7770- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- in-vitro, Lung, NA - vitro+vivo, BC, 4T1
necrosis↑, ROS↑, mtDam↑, Ca+2↑, NA↑, MMP↓, TumCG↓,
7767- IBC,    Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway
- vitro+vivo, GC, NA
TumCG↓, ROS↑, DHODH↓, MMP↓, cGAS–STING↑, Imm↑, mtDam↑,
7772- IBC,    Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation
- vitro+vivo, AML, NA
Apoptosis↑, Diff↑, tumCV↓, TumCP↓, MMP↓, BAX↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, p‑MEK↑, p‑ERK↑, ROS↑, eff↓,
7636- Ins,    Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models
*glucose↝, *lipid-P↓, *ROS↓, *BioAv↑, *hepatoP↑, *Inflam↓, *MMP↑, *ATP↑, *GutMicro↑, *Dose↝, *Half-Life↝, *BioAv↑, *eff↑, *hepatoP↑, *SOD↑, *Catalase↑, *Casp3↓, *ALAT↓, *AST↓, *AMPK↑, *SREBP1/SREBF1↑, *NA↑,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7724- IP6,    Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway
- in-vitro, Cerv, HeLa
NF-kB↓, Akt↓, MMP↓, Cyt‑c↑, Apoptosis↑, Casp3↑, Casp9↑, PARP↑, eff↑,
7730- isoFl,    Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years
- Review, Var, NA
Apoptosis↑, ROS↓, TumCCA↓, TumCMig↓, TumCI↓, MMP↓, angioG↓, ChemoSen↑, p‑Akt↓, p‑mTOR↓, cl‑PARP↑, cycA1/CCNA1↓, CycB/CCNB1↓, STAT3↓,
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
7856- isoO,    Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
- in-vitro, Lung, A549
Bacteria↓, Inflam↓, TumCD↑, selectivity↑, Apoptosis↑, MMP↓, BAX↑, cl‑Casp3↑, PARP↓, Bcl-2↓, TumCCA↑, CycB/CCNB1↓, CDK1↓, CDK2↓, NA↑, p27/CDKN1B↑, ROS↑, eff↓, p‑p38↑, p‑JNK↑, ERK↓, STAT3↓, NF-kB↓,
7885- isoO,    Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway
Dose↝, tumCV↓, TumCP↓, LDH↑, TumCCA↑, ROS↑, MMP↓, BAX↑, Bcl-2↓, Cyt‑c↑, Casp3↑, Casp9↑,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7872- isoO,    Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
- in-vivo, Arthritis, NA
*antiOx↑, *MMP↑, *Apoptosis↓, *MAPK↓, *SOD↑, *HO-1↑, *NQO1↑, *MDA↓, *ROS↓, *NRF2↑, *PI3K↑, *Akt↑,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
8011- itraC,    Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death
- vitro+vivo, BC, MCF7 - vitro+vivo, BC, SkBr3
MMP↓, Bcl-2↓, Casp3↑, TumAuto↑, LC3II↑, p62↓, HH↓, Shh↓, Gli1↓, Apoptosis↑, TumVol↓, eff↑, TumCCA↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8038- IVM,    Ivermectin and gemcitabine combination treatment induces apoptosis of pancreatic cancer cells via mitochondrial dysfunction
- in-vitro, PC, NA
*AntiP↑, AntiTum↑, ChemoSen↑, TumCP↓, TumCCA↑, cycD1/CCND1↓, mTOR↓, STAT3↑, Apoptosis↑, mtDam↑, ROS↑, MMP↓, OCR↓, MitoP↓,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, eff↑, *AntiP↑,
8028- IVM,    Ivermectin as an Alternative Anticancer Agent: A Review of Its Chemical Properties and Therapeutic Potential
- Review, Var, NA
*BioAv↝, Apoptosis↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, TumMeta↓, PI3K↓, Akt↓, mTOR↓, TumPF↓, CSCs↓, eff↑, ChemoSen↑, mtDam↑, MMP↓, ATP↓, ROS↑, NF-kB↓, BAX↑, Casp3↑, Casp9↑, ICD↑, Ki-67↓, PSA↓, YAP/TEAD↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8022- IVM,    Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
- vitro+vivo, RCC, NA
AntiP↑, TumCP↓, Apoptosis↑, selectivity↑, TumCG↓, MMP↓, mitResp↓, ATP↓, ROS↑, eff↓,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8045- IVM,    Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway
- in-vitro, Cerv, HeLa
tumCV↓, TumCCA↑, DNA-PK↑, ChrMod↝, MMP↓, Bax:Bcl2↑, Cyt‑c↓, Casp9↑, Casp3↑, ROS↑, TumCMig↓,

Showing Research Papers: 401 to 450 of 723
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 723

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,   DHODH↓, 2,   HTRA2/Omi/PARK13↑, 1,   MTA1↓, 1,   NA↑, 2,   TFE3↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   compI↓, 2,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   ICD↑, 4,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   PARK2↑, 1,   ROS↓, 3,   ROS↑, 24,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 1,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 5,   e-ATP↑, 1,   p‑MEK↑, 1,   mitResp↓, 2,   MMP↓, 40,   MPT↑, 2,   mtDam↑, 11,   OCR↓, 3,   PINK1↑, 1,   c-Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 1,   LDH↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 8,   p‑Akt↓, 5,   Apoptosis↑, 23,   BAD↑, 2,   Bak↑, 1,   BAX↑, 15,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 15,   Bcl-xL↓, 6,   Casp↑, 2,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 17,   cl‑Casp3↑, 5,   proCasp3↓, 1,   Casp7↑, 1,   Casp8↑, 6,   Casp9↑, 12,   cl‑Casp9↑, 2,   Cyt‑c↓, 1,   Cyt‑c↑, 16,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 1,   Hippo↓, 1,   IAP1↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 2,   Mcl-1↑, 1,   necrosis↑, 2,   p27/CDKN1B↑, 3,   p‑p38↑, 1,   survivin↓, 4,   TRAILR↑, 1,   TumCD↑, 6,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1,   cJun↑, 1,   p‑cJun↑, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↑, 1,   LC3B-II↑, 1,   LC3II↑, 3,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNA-PK↑, 1,   DNAdam↓, 1,   DNAdam↑, 2,   P53↑, 5,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 6,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   mitA↓, 1,   P21?, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD24↓, 1,   CD44↓, 2,   CSCs↓, 6,   Diff↑, 2,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 1,   p‑ERK↑, 2,   FOXO4↑, 1,   Gli1↓, 2,   HDAC↓, 1,   HDAC1↓, 1,   HDAC3↓, 1,   HH↓, 2,   miR-34a↑, 1,   mTOR↓, 6,   p‑mTOR↓, 3,   mTORC1↓, 2,   Nanog↓, 2,   Nestin↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 4,   PTCH1↓, 1,   RAS↓, 1,   Shh↓, 2,   SOX2↓, 2,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   TCF↓, 1,   TCF↝, 1,   TumCG↓, 5,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↑, 3,   E-cadherin↑, 1,   Ki-67↓, 1,   LRP1↓, 1,   MMP2↓, 3,   MMP9↓, 2,   MMPs↓, 2,   N-cadherin↓, 1,   PAK1↓, 1,   PAK1↑, 1,   Snail↓, 1,   SOX4↓, 1,   TIMP2↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 11,   TumCP↑, 1,   TumMeta↓, 2,   TumPF↓, 1,   Twist↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 2,   NO↑, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 2,   P-gp/ABCB1↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HMGB1↑, 1,   IKKα↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 8,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,   TLR1↑, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

cGAS–STING↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   ChemoSen↑, 6,   Dose?, 1,   Dose↝, 4,   eff↓, 10,   eff↑, 9,   Half-Life↓, 1,   Half-Life↝, 3,   MDR1↓, 1,   selectivity↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,   Ki-67↓, 1,   LDH↑, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 1,   OS↑, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 247

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 2,   antiD↓, 1,   AntiP↑, 4,   NA↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 7,   Catalase↑, 4,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 3,   GSH↑, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 1,   MDA↓, 1,   NQO1↑, 2,   NRF2↑, 3,   OXPHOS↓, 1,   OXPHOS↑, 1,   ROS↓, 13,   mt-ROS↓, 2,   SIRT3↑, 3,   SOD↑, 4,   TAC↑, 1,   Trx1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MMP↓, 2,   MMP↑, 9,   PGC-1α↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ALAT↓, 4,   AMPK↑, 3,   p‑AMPK↑, 2,   BMAL1↑, 1,   BUN↓, 1,   ECAR↓, 1,   glucose↝, 1,   Glycolysis↓, 1,   Glycolysis↑, 1,   LDH↑, 1,   PPARα↑, 1,   PPARγ↑, 2,   SREBP1/SREBF1↑, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   p‑Akt↑, 2,   Apoptosis↓, 2,   Casp3↓, 2,   Casp3↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   AntiThr↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   PI3K↑, 1,   p‑PI3K↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 2,   CXCL12↑, 1,   MMP2↑, 1,   PAI-1/SERPINE1↓, 1,   ZO-1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CLDN5↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 2,   Inflam↓, 9,   NF-kB↓, 1,   PAR-2↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,   eff↑, 2,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   AST↓, 4,   BP↓, 1,   GutMicro↑, 1,   LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 3,   cardioP↑, 2,   cognitive↑, 1,   hepatoP↑, 5,   memory↑, 1,   motorD↑, 2,   neuroP?, 1,   neuroP↑, 5,   RenoP↑, 1,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 111

Scientific Paper Hit Count for: MMP, ΔΨm, mitochondrial membrane potential
31 Silver-NanoParticles
25 Quercetin
21 Betulinic acid
21 Capsaicin
17 Baicalein
17 Propolis -bee glue
17 Fisetin
16 Curcumin
16 Berberine
15 Sulforaphane (mainly Broccoli)
15 Emodin
15 Shikonin
15 Thymoquinone
14 Apigenin (mainly Parsley)
14 Magnetic Fields
11 Chrysin
11 Resveratrol
10 Ashwagandha(Withaferin A)
10 Electrical Pulses
10 Gambogic Acid
10 Graviola
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
9 Ivermectin
9 Vitamin K2
8 Allicin (mainly Garlic)
8 Dichloroacetate
8 Honokiol
8 Kaempferol
8 Licochalcone A
8 Phenethyl isothiocyanate
7 Cisplatin
7 Radiotherapy/Radiation
7 Dandelion Root
7 EGCG (Epigallocatechin Gallate)
7 Juglone
7 Phenylbutyrate
7 salinomycin
6 chitosan
6 Beta-Caryophyllene
6 Carvacrol
6 Luteolin
6 Parthenolide
5 Alpha-Lipoic-Acid
5 Artemisinin
5 doxorubicin
5 Rosmarinic acid
5 Eugenol
5 Ferulic acid
5 isoorientin
5 Vitexin
5 Lycopene
5 Magnetic Field Rotating
5 Selenium NanoParticles
5 Ursolic acid
4 Auranofin
4 Vitamin C (Ascorbic Acid)
4 Metformin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 chaetocin
4 Selenium
4 Copper and Cu NanoParticles
4 Date Fruit Extract
4 Ginkgo biloba-EGb 761
4 Evodiamine
4 Formononetin
4 Gallic acid
4 Garcinol
4 HydroxyTyrosol
4 Hyperoside
4 Indole-3-carbinol
4 Isobavachalcone
4 Propyl gallate
4 Taurine
3 SonoDynamic Therapy UltraSound
3 Isovitexin
3 Boron
3 Thymol-Thymus vulgaris
3 Crocetin
3 Carvone
3 Cynaropicrin
3 Diclofenac
3 Ellagic acid
3 Fucoidan
3 Geraniol
3 Gossypol/AT-101
3 Hibiscus sabdariffa
3 isoquercitrin
3 Linalool
3 Piperlongumine
3 Spermidine
3 Urolithin
2 Astragalus
2 Gemcitabine (Gemzar)
2 5-fluorouracil
2 Anethole/trans-Anethole
2 Baicalin
2 Biochanin A
2 Bufalin/Huachansu
2 Bullatacin
2 Celecoxib
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cinnamon
2 Hydroxycinnamic-acid
2 Citric Acid
2 Coenzyme Q10
2 Fenbendazole
2 Paclitaxel/Taxol
2 Ginseng
2 γ-linolenic acid (Borage Oil)
2 Gold NanoParticles
2 Hydrogen Gas
2 Hyperthermia
2 Photodynamic Therapy
2 Magnolol
2 Nimbolide
2 Piperine
2 Plumbagin
2 Psoralidin
2 VitK3,menadione
1 2-DeoxyGlucose
1 Glucose
1 Camptothecin
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Andrographis
1 Angelica archangelica / Garden Angelica
1 Astaxanthin
1 Atorvastatin
1 Aloe anthraquinones
1 Berbamine
1 D-limonene
1 Cannabidiol
1 Brucea javanica
1 Bromelain
1 Chemotherapy
1 Bruteridin(bergamot juice)
1 buckwheat sprouts
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 Vitamin E
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Dihydrocaffeic Acid
1 Cyclopamine
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Mistletoe/Viscum album Extracts
1 Disulfiram
1 Shilajit/Fulvic Acid
1 hydroxychloroquine
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Helleborus niger extracts – Christmas Rose
1 Inositol
1 iodine
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 isoflavones
1 itraconazole
1 Geldanamycin
1 Licorice
1 Lemongrass Extract/Citral
1 1,8-Cineole
1 Methylene blue
1 Methyl Jasmonate
1 Melatonin
1 Methylglyoxal
1 Moringa oleifera
1 Mushroom Chaga
1 Bicarbonate(Sodium)
1 No Product/Mechanism Only
1 Oleuropein
1 temozolomide
1 Pterostilbene
1 Rauwolfia serpentina/Indian Snakeroot
1 Oxaliplatin
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Sulfasalazine
1 polyethylene glycol
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:197  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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