mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
8159- UsA,    Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity
- in-vitro, Cerv, HeLa
STAT3↓, RAS↓, mTOR↓, PD-L1↓, TumCP↓, angioG↓, TumCMig↓, TumCI↓, TumCG↓,
3145- VitC,    Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect
- in-vitro, CRC, HCT116
Warburg↓, TumCG↓, Glycolysis↓, GlucoseCon↓, ATP↓, lactateProd↓, selectivity↑, GLUT1↓, PKM2↓, LDHA↓, mTOR↓,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,
7921- VT,    Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
- in-vitro, Colon, Caco-2
Dose↝, tumCV↓, SOD↓, Catalase↓, MDA↑, P53↑, BAX↓, TSC2↑, SESN2↑, PUMA↑, AMPK↑, PI3K↑, Akt↑, mTOR↓,
7914- VT,    Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells
- vitro+vivo, Lung, A549
tumCV↓, selectivity↑, Cyt‑c↑, MMP↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, TumCG↓, mtDam↑, LDH↑, Bax:Bcl2↑, cl‑Casp3↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 401 to 414 of 414
Prev Page 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 414

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   MDA↑, 1,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mitResp↓, 1,   MMP↓, 2,   mtDam↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   cMyc↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 5,   HK2↓, 2,   lactateProd↓, 2,   LDH↑, 1,   LDHA↓, 3,   PFK↓, 1,   PKM2↓, 3,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 3,   Apoptosis↑, 4,   BAX↓, 1,   Bax:Bcl2↑, 1,   Casp↑, 1,   cl‑Casp3↑, 1,   Chk2↓, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   MAPK↓, 1,   MDM2↑, 1,   PUMA↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↓, 1,   SESN2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 1,   DNAdam↑, 1,   P53↑, 2,   p53 Wildtype↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   EMT↓, 2,   ERK↓, 2,   IGF-1↓, 1,   mTOR↓, 8,   p‑mTOR↓, 3,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 2,   PI3K↑, 1,   p‑PI3K↓, 1,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 2,   TumCG↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 3,   F-actin↑, 1,   N-cadherin↓, 2,   Snail↓, 1,   Treg lymp↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   Vim↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   Hif1a↓, 1,   TAMS↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 1,   Half-Life↝, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   GutMicro↑, 1,   IL6↓, 1,   LDH↑, 1,   NOS2↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 100

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   Ferroptosis↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   PARK2↑, 2,   ROS↓, 3,   SIRT3↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   LDL↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   MitoP↑, 2,   p62↓, 1,   p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 2,   mTOR↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 3,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 2,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   motorD↑, 1,   neuroP↑, 3,   radioP↑, 1,   Risk↓, 2,   Strength↑, 2,   toxicity↓, 2,  
Total Targets: 59

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
22 Curcumin
19 Fisetin
15 Quercetin
14 Berberine
13 Baicalein
11 Ivermectin
9 Thymoquinone
9 Resveratrol
9 itraconazole
8 Apigenin (mainly Parsley)
8 Magnetic Fields
8 EGCG (Epigallocatechin Gallate)
8 Honokiol
8 Shikonin
7 Alpha-Lipoic-Acid
7 Artemisinin
7 Sulforaphane (mainly Broccoli)
7 Isoliquiritigenin
6 Chemotherapy
6 diet FMD Fasting Mimicking Diet
6 Lycopene
6 Urolithin
5 Capsaicin
5 Hydrogen Gas
5 Licochalcone A
5 Magnolol
5 Metformin
5 Piperlongumine
5 Rosmarinic acid
5 Silymarin (Milk Thistle) silibinin
4 5-fluorouracil
4 Ashwagandha(Withaferin A)
4 Beta-Caryophyllene
4 Chlorogenic acid
4 Chrysin
4 Cinnamon
4 Citric Acid
4 Dichloroacetate
4 Gambogic Acid
4 Hyperoside
4 Isovitexin
4 Vitexin
4 Kaempferol
4 Piperine
4 Pterostilbene
3 Coenzyme Q10
3 Astragalus
3 Cisplatin
3 brusatol
3 Carnosic acid
3 salinomycin
3 diet Short Term Fasting
3 Eugenol
3 Ginkgolide B
3 HydroxyTyrosol
3 isoquercitrin
3 Magnetic Field Rotating
3 Naringin
2 1,8-Cineole
2 Auranofin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Anethole/trans-Anethole
2 Betulinic acid
2 Brucea javanica
2 Boswellia (frankincense)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Propolis -bee glue
2 Hydroxycinnamic-acid
2 Calorie Restriction Mimetics
2 Ursolic acid
2 CUSP9
2 Deguelin
2 Dandelion Root
2 Ellagic acid
2 Emodin
2 Ferulic acid
2 Formononetin
2 Garcinol
2 Ginkgetin
2 Juglone
2 Lasiodin
2 Luteolin
2 Niclosamide (Niclocide)
2 doxorubicin
2 Plumbagin
2 α-Santalol/Sandalwood oil
2 Vitamin D3
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 2-DeoxyGlucose
1 Baicalin
1 Biochanin A
1 Bufalin/Huachansu
1 Butyrate
1 Trastuzumab
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Cichoric acid / Chicoric acid
1 immunotherapy
1 Spermidine
1 Aspirin
1 Crocetin
1 Radiotherapy/Radiation
1 diet Methionine-Restricted Diet
1 flavonoids
1 Fucoidan
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 HydroxyCitric Acid
1 Huperzine A/Huperzia serrata
1 Inulin Prebiotic
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 isoflavones
1 Sorafenib (brand name Nexavar)
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Licorice
1 Lactoferrin/Talactoferrin
1 Methylene blue
1 Mung Bean Sprouts
1 MCToil
1 Nimbolide
1 Oleuropein
1 Oleocanthal
1 sericin
1 Phenethyl isothiocyanate
1 Parthenolide
1 Gold NanoParticles
1 Selenium
1 Selenium NanoParticles
1 acetazolamide
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Usnic acid
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:209  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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