Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱
Source:
Type:
Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.
Scientific Papers found: Click to Expand⟱
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
6274- DL,    Protective Effect of D-Limonene against Oxidative Stress-Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
- in-vitro, Nor, NA
*antiOx↑, *ROS↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *Bax:Bcl2↑, *p‑p38↓,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
6288- DL,    From Citrus to Clinic: Limonene’s Journey Through Preclinical Research, Clinical Trials, and Formulation Innovations
- Review, Var, NA - Review, AD, NA
other↑, DDS↑, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *neuroP↑, *Imm↑, *Wound Healing↑, *other↑, *BioAv↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *DNAdam↓, *AntiDiabetic↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, *AChE↓, *BChE↓, *Aβ↓, *ROS↓, *toxicity?,
6280- DL,    Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs
- Review, Var, NA
BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, TGF-β↑, Bcl-2↓, VEGF↓, AntiTum↑, *Inflam↓, *Bacteria↓,
6344- DRE,    Dandelion: Purported Benefits, Side Effects & More
- Review, Var, NA
*other↝, *hepatoP↑, *ALAT↓, *MDA↓, *TNF-α↓, *IL6↓, *antiOx↑, *Inflam↓, *proCasp3↓, Casp3↑, tumCV↓, TNF-α↑, IL1↑,
6350- DRE,    Tracking Evidences of Dandelion for the Treatment of Cancer: From Chemical Composition, Bioactivity, Signaling Pathways in Cancer Cells to Perspective Study
- Review, Var, NA
AntiCan↑, *Bacteria↓, *Inflam↓, *antiOx↑, TumCCA↑, Apoptosis↑, MOMP↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, MMP↓, Bcl-2↓, TumCMig↓, TumCI↓, Wnt↓, β-catenin/ZEB1↓, MMP2↓, MMP9↓, TumAuto↑, mTOR↓, 4E-BP1↓, Glycolysis↓, angioG↓,
6319- DRE,    Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
- in-vitro, AML, MV411 - in-vitro, AML, HL-60
Apoptosis↑, TumAuto↑, *toxicity↓, selectivity↑, Casp8↑, MMP↓, *Inflam↓, *antiOx↑, *AntiCan↑, DNAdam↑, cl‑Casp3↑, tumCV↓, ROS↑,
6320- DRE,    Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
Apoptosis↑, MMP↓, TumAuto↑, selectivity↑, eff↑, Casp8↑, Casp3↑, cl‑BID↑, mtDam↑, ROS↑,
6353- DRE,  Cisplatin,    Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Cyt‑c↓, *DNAdam↓, *GSH↑, *SOD↑, *Albumin↝, *creat↓, *BUN↓, *RenoP↑, *lipid-P↓, *TNF-α↓, *Casp3↓, *Casp9↓, *chemoP↑,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
6608- Ech,  CBC,    The pro-apoptosis effects of Echinacea purpurea and Cannabis sativa extracts in human lung cancer cells through caspase-dependent pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, ROS↑, Casp3↑, TumCD↑,
6620- Ech,    Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans
- in-vivo, Var, NA
angioG↓, *NK cell↑, Imm↑, Inflam↓, tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, MMPs↓, other↑,
7194- EGb 761,    Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
- in-vitro, Oral, NA
Casp3↑, Apoptosis↑, Dose↝, TumCP↓, cl‑PARP↑, AntiCan↑,
7208- EGb 761,    EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
- in-vitro, Nor, SH-SY5Y
*Ca+2↑, *Apoptosis↓, *ROS↓, *MMP↑, *Casp3↓, *Casp9↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3203- EGCG,    (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress
- NA, MM, NA
ROS↑, Ca+2↝, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, *GRP78/BiP↓, *UPR↓, UPR↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
3206- EGCG,    Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration
- Review, AMD, NA
*Ca+2↓, *ROS↓, *Apoptosis↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *PERK↓, *IRE1↓, *p‑PARP↓, *Casp3↓, *Casp12↓, *ER Stress↓, *UPR↓,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
20- EGCG,    Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
- in-vivo, Liver, NA - in-vivo, Tong, NA
HH↓, Gli1↓, Smo↓, TNF-α↓, COX2/PTGS2↓, *antiOx↑, Hif1a↓, NF-kB↓, VEGF↓, STAT3↓, Bcl-2↓, P53↑, Akt↓, p‑Akt↓, p‑mTOR↓, EGFR↓, AP-1↓, BAX↑, ROS↑, Casp3↑, Apoptosis↑, NRF2↑, *H2O2↓, *NO↓, *SOD↑, *Catalase↑, *GPx↑, *ROS↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
989- EGCG,  Citrate,    In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
- in-vitro, HCC, NA - in-vivo, NA, NA
PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
668- EGCG,    The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
- Review, BC, MCF7 - Review, BC, MDA-MB-231
HER2/EBBR2↓, EGFR↓, mtDam↑, ROS↑, PI3K/Akt↓, P53↑, P21↑, Casp3↑, Casp9↑, BAX↑, PTEN↑, Bcl-2↓, hTERT/TERT↓, STAT3↓, TumCCA↑, Hif1a↓,
689- EGCG,    EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF-κB and MMP-9
- vitro+vivo, Bladder, SW780
Casp8↑, Casp9↑, Casp3↑, BAX↑, PARP↑, TumVol↓, NF-kB↓, MMP9↓,
681- EGCG,    Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models
- vitro+vivo, BC, NA
Casp3↑, Casp8↑, Casp9↑, TumAuto↑, Beclin-1/ATG6↝, ATG5↝, GlucoseCon↓, lactateProd↓, ATP↝, HK2↓, LDHA↓, Hif1a↓, GLUT1↓, TumVol↓, VEGF↓,
1976- EGCG,    Epigallocatechin-3-gallate exhibits anti-tumor effect by perturbing redox homeostasis, modulating the release of pro-inflammatory mediators and decreasing the invasiveness of glioblastoma cells
- in-vitro, GBM, U87MG
ROS↑, MMP↓, Casp3↑, Cyt‑c↑, Trx1↓, Ceru↓, IL6↓, IL8↓, MCP1/CCL2↓, RANTES?, uPA↝, ROS↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
1332- EMD,    Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway
- in-vivo, Nor, HepaRG
*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,
1327- EMD,    Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway
- in-vitro, Lung, A549
Cyt‑c↑, Casp2↑, Casp3↑, Casp9↑, ERK↓, Akt↓, ROS↑, MMP↓, Bcl-2↓, BAX↑,
1323- EMD,    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
- Review, Cerv, NA
TumCCA↑, DNAdam↑, mTOR↓, Casp3↑, Casp8↑, Casp9↑, TGF-β↑, SMAD3↓, p‑SMAD4↓, ROS↑, MMP↓, CXCR4↓, HER2/EBBR2↓, ER Stress↓, TumAuto↑, NOTCH1↓,
1325- EMD,  PacT,    Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
- vitro+vivo, Lung, A549
TumCP↓, Apoptosis↑, BAX↑, Casp3↑, Bcl-2↓, p‑Akt↓, p‑ERK↓, ChemoSideEff∅, ChemoSen↑,
1318- EMD,    Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species
- in-vitro, Nor, HL7702
*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,
1328- EMD,    Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
- in-vitro, Tong, SCC4
TumCCA↑, P21↑, Chk2↑, CycB/CCNB1↓, cDC2↓, Apoptosis↑, Cyt‑c↑, Casp9↑, Casp3↑, ROS↑, MMP↓, Bax:Bcl2↑, ER Stress↑,
1329- EMD,    Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
- in-vitro, Tong, SCC4
TumCCA↑, eff↓, P53↑, P21↑, p27/CDKN1B↑, cycA1/CCNA1↓, cycE/CCNE↓, TS↓, CDC25↓, AIF↑, proCasp9↓, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp9↑,
1331- EMD,    Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
- in-vitro, NPC, NA
TumCCA↑, CycB/CCNB1↑, DNAdam↑, Casp3↑, cl‑PARP↑, MMP↓, Ca+2↑, ROS↑,
1330- EMD,    Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway
- in-vitro, NA, NA
tumCV↓, Casp3↑, Casp9↑, MMP↓, Cyt‑c↑, BAX↑, Bax:Bcl2↑,
1245- EMD,    Emodin Exhibits Strong Cytotoxic Effect in Cervical Cancer Cells by Activating Intrinsic Pathway of Apoptosis
- in-vitro, Cerv, HeLa
TumCG↓, TumCP↓, Apoptosis↑, ROS↑, Casp3↑, Casp9↑, MMP↓, DNAdam↑, GSH↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,

Showing Research Papers: 401 to 450 of 1040
Prev Page 9 of 21 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1040

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   Ceru↓, 1,   GSH↓, 4,   GSTs↑, 1,   HO-1↓, 2,   HO-2↓, 1,   MAD↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 24,   TBARS↑, 1,   Trx1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↝, 1,   CDC25↓, 1,   MMP↓, 16,   MMP↑, 1,   mtDam↑, 4,   OCR↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 2,   ECAR↝, 1,   GlucoseCon↓, 3,   GLUT2↓, 1,   GlutMet↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   lactateProd↓, 4,   LDH↓, 2,   LDH↑, 1,   LDHA↓, 1,   PDH↝, 1,   PDK1 / PDPK1?, 2,   PFK↓, 1,   PI3K/Akt↓, 1,   PKM2∅, 1,   cl‑PPARα↓, 1,   SIRT1↓, 3,   TS↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↓, 6,   APAF1↑, 1,   Apoptosis↑, 22,   BAD↑, 3,   Bak↑, 3,   BAX↑, 15,   BAX⇅, 1,   Bax:Bcl2↑, 7,   Bcl-2↓, 16,   Bcl-xL↓, 4,   cl‑BID↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp2↑, 1,   Casp3↑, 39,   cl‑Casp3↑, 3,   Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 9,   Casp9↑, 17,   cl‑Casp9↑, 1,   proCasp9↓, 1,   Chk2↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 13,   Cyt‑c↝, 1,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   HEY1↓, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 2,   Mcl-1↓, 2,   MDM2↓, 1,   MDM2↑, 1,   MOMP↑, 1,   Myc↓, 2,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 5,   Telomerase↓, 4,   TumCD↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   miR-25-5p↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   HATs↓, 1,   other↑, 2,   pRB↑, 1,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 2,   ER Stress↓, 1,   ER Stress↑, 7,   GRP78/BiP↑, 3,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG5↝, 1,   Beclin-1/ATG6↑, 1,   Beclin-1/ATG6↝, 1,   LC3B↑, 1,   LC3II↑, 2,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 7,   DNMTs↓, 3,   p16↑, 1,   P53↑, 12,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↑, 8,   PCNA↓, 4,   SIRT6↑, 1,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1/2/5/9↓, 1,   CDK2↓, 3,   CDK2↑, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 3,   P21↓, 1,   P21↑, 6,   p‑RB1↓, 1,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   cDC2↓, 1,   CDK8↓, 1,   CIP2A↓, 1,   CSCs↓, 2,   EMT↓, 5,   ERK↓, 1,   ERK↑, 1,   p‑ERK↓, 2,   FOXO↑, 1,   Gli↓, 1,   Gli1↓, 3,   HDAC↓, 2,   HDAC1↓, 1,   HH↓, 3,   IGF-1↓, 1,   IGF-1R↑, 1,   Jun↓, 1,   miR-34a↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 3,   NOTCH1↓, 3,   NOTCH3↓, 2,   OCT4↓, 1,   PI3K↓, 3,   PTCH1↓, 1,   PTCH2↓, 1,   PTEN↑, 4,   Shh↓, 2,   Smo↓, 2,   STAT3↓, 5,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   TumCG↓, 4,   Wnt↓, 2,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 2,   Ca+2↑, 1,   Ca+2↝, 2,   E-cadherin↑, 2,   ER-α36↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   GLI2↓, 2,   Ki-67↓, 3,   MMP2↓, 7,   MMP9↓, 10,   MMPs↓, 3,   PDGF↓, 1,   PKCδ↓, 2,   Slug↓, 2,   Smad1↓, 1,   SMAD3↓, 2,   p‑SMAD4↓, 1,   Snail↓, 4,   TGF-β↓, 2,   TGF-β↑, 3,   TIMP1↑, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 7,   TumCMig↓, 5,   TumCP↓, 13,   TumMeta↓, 2,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 2,   uPA↝, 1,   Vim↓, 1,   Zeb1↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 4,   EGFR↓, 5,   Endoglin↑, 1,   Hif1a↓, 9,   VEGF↓, 9,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 2,   NHE1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 7,   CXCR4↓, 1,   IL1↑, 1,   IL1β↑, 1,   IL6↓, 3,   IL8↓, 2,   Imm↑, 3,   Inflam↓, 2,   JAK↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   RANTES?, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   BioAv∅, 1,   ChemoSen↑, 7,   DDS↑, 1,   Dose↝, 2,   Dose∅, 2,   eff↓, 3,   eff↑, 9,   Half-Life↝, 1,   Half-Life∅, 1,   RadioS↑, 3,   selectivity↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 1,   IL6↓, 3,   Ki-67↓, 3,   LDH↓, 2,   LDH↑, 1,   Myc↓, 2,   PD-L1↓, 1,   TG/TAG↓, 1,   TP53↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   ChemoSideEff∅, 1,   toxicity∅, 1,   TumVol↓, 3,  
Total Targets: 281

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 4,   H2O2↓, 1,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 14,   ROS↑, 2,   SOD↑, 6,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↓, 1,   BUN↓, 1,   glucose↓, 1,   LDH↓, 1,   LDL↓, 2,   NAD↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 5,   BAX↓, 2,   Bax:Bcl2↑, 3,   Bcl-2↓, 1,   Casp12↓, 1,   Casp3↓, 6,   Casp3↑, 1,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↓, 4,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↓, 3,   Fas↑, 2,   GADD34↓, 1,   iNOS↓, 2,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   ER Stress↓, 1,   GRP78/BiP↓, 2,   IRE1↓, 1,   PERK↓, 1,   UPR↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   P53↓, 2,   P53↑, 2,   p‑PARP↓, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycE/CCNE↑, 1,   E2Fs↑, 1,   P21↓, 2,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1R↓, 1,   mTOR↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 1,   MMP2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   NO↓, 3,   PDGFR-BB↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↓, 1,   Imm↑, 1,   Inflam↓, 11,   JAK↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 5,   BioAv↝, 1,   Dose↝, 1,   Dose∅, 1,   eff↑, 2,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   Albumin↝, 1,   AST↓, 1,   creat↓, 1,   GutMicro↑, 3,   IL6↓, 4,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 3,   cardioP↑, 3,   chemoP↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 6,   Obesity↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity?, 1,   toxicity↓, 2,   toxicity↝, 2,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 3,  
Total Targets: 134

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3
36 Silver-NanoParticles
35 Quercetin
32 Curcumin
29 Thymoquinone
26 Apigenin (mainly Parsley)
23 Sulforaphane (mainly Broccoli)
21 Baicalein
21 Berberine
18 EGCG (Epigallocatechin Gallate)
18 Emodin
18 Fisetin
17 Shikonin
16 Chrysin
16 Honokiol
15 Propolis -bee glue
14 Artemisinin
14 Magnetic Fields
14 Allicin (mainly Garlic)
14 Capsaicin
14 Licochalcone A
13 Cisplatin
13 Ashwagandha(Withaferin A)
13 Kaempferol
12 Betulinic acid
12 Boron
12 Silymarin (Milk Thistle) silibinin
11 Eugenol
11 Gambogic Acid
11 Hyperoside
10 Radiotherapy/Radiation
10 Chlorogenic acid
10 Ginkgetin
10 Graviola
10 isoorientin
10 Juglone
10 Luteolin
10 Resveratrol
9 Alpha-Lipoic-Acid
9 Carvacrol
9 Magnolol
9 Phenylbutyrate
8 doxorubicin
8 D-limonene
8 Citric Acid
8 Dandelion Root
8 Formononetin
8 Garcinol
8 Ivermectin
8 Lycopene
7 5-fluorouracil
7 Gallic acid
7 Isobavachalcone
7 Vitexin
7 Phenethyl isothiocyanate
7 Piperlongumine
7 Rosmarinic acid
6 Beta-Caryophyllene
6 Bufalin/Huachansu
6 chaetocin
6 chitosan
6 Ferulic acid
6 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
6 Nimbolide
6 Selenite (Sodium)
6 Vitamin K2
5 Boswellia (frankincense)
5 α-Bisabolol / Chamomile oil
5 Caffeic acid
5 Chemotherapy
5 Centella asiatica / Gotu kola → asiaticoside
5 Crocetin
5 Ursolic acid
5 Dichloroacetate
5 salinomycin
5 Ellagic acid
5 Paclitaxel/Taxol
5 Evodiamine
5 Isoliquiritigenin
5 isoquercitrin
5 lambertianic acid
5 Magnetic Field Rotating
5 Plumbagin
5 Aflavin-3,3′-digallate
4 3-bromopyruvate
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Melatonin
4 Anethole/trans-Anethole
4 Astaxanthin
4 Photodynamic Therapy
4 Bromelain
4 borneol
4 Carvone
4 Cucurbitacin
4 Geraniol
4 Isovitexin
4 Lemongrass Extract/Citral
4 Naringin
4 Propyl gallate
4 Piperine
4 VitK3,menadione
4 Urolithin
3 Auranofin
3 Metformin
3 Berbamine
3 Biochanin A
3 Brucea javanica
3 Carnosic acid
3 Thymol-Thymus vulgaris
3 Celastrol
3 Cynaropicrin
3 Deguelin
3 Date Fruit Extract
3 Docetaxel
3 Echinacea
3 Fenbendazole
3 Fucoidan
3 Ginkgo biloba
3 Ginkgolide B
3 Gossypol/AT-101
3 Hydrogen Gas
3 Hydroxycinnamic-acid
3 Hibiscus sabdariffa
3 Helleborus niger extracts – Christmas Rose
3 Rutin
3 itraconazole
3 Laetrile B17 Amygdalin
3 Psoralidin
3 Pterostilbene
3 α-Santalol/Sandalwood oil
3 Vitamin C (Ascorbic Acid)
2 1,8-Cineole
2 Coenzyme Q10
2 Astragalus
2 SonoDynamic Therapy UltraSound
2 entinostat
2 Gemcitabine (Gemzar)
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Fennel Oil/Foeniculum vulgare
2 Aloe anthraquinones
2 brusatol
2 Bullatacin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Cat’s Claw
2 Cichoric acid / Chicoric acid
2 methotrexate
2 Cinnamon
2 Copper and Cu NanoParticles
2 Diclofenac
2 diet FMD Fasting Mimicking Diet
2 Ginkgo biloba-EGb 761
2 Electrical Pulses
2 Eurycomanone
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 HydroxyCitric Acid
2 HydroxyTyrosol
2 Huperzine A/Huperzia serrata
2 Inositol
2 Licorice
2 Lactoferrin/Talactoferrin
2 Magnesium
2 Oleuropein
2 Parthenolide
2 Selenium
2 Selenium NanoParticles
2 Vitamin D3
1 5-Aminolevulinic acid
1 Camptothecin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 alpha Linolenic acid
1 DTS(dibenzyl trisulphide) from Anamu
1 Angelica archangelica / Garden Angelica
1 2-DeoxyGlucose
1 Ascorbyl Palmitate
1 Trastuzumab
1 almonertinib
1 epirubicin
1 temozolomide
1 Bacopa monnieri
1 Butyrate
1 Mung Bean Sprouts
1 Sorafenib (brand name Nexavar)
1 immunotherapy
1 Polyphenols
1 Oxaliplatin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 diet Methionine-Restricted Diet
1 Cannabichromene
1 eicosapentaenoic acid
1 ferumoxytol
1 Geldanamycin
1 Radicicol/monorden
1 Bortezomib
1 carboplatin
1 Galloflavin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 hydrogen sulfide
1 Orlistat
1 Hyperthermia
1 Indole-3-carbinol
1 iodine
1 Inulin Prebiotic
1 Morin
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lapachol
1 Lasiodin
1 Linalool
1 Lutein
1 Iron
1 Myricetin
1 nelfinavir/Viracept
1 sericin
1 isoflavones
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 Scoulerine
1 polyethylene glycol
1 Folic Acid, Vit B9
1 Osimertinib
1 Adagrasib
1 Terpinen-4-ol / Tea Tree Oil
1 Taurine
1 triptolide
1 Turmerones
1 Vitamin B1/Thiamine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:42  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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