| Source: |
| Type: |
| Process through which new blood vessels. Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body. Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis. Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth. -Tumour development and progression beyond a size of few millimetres‐cubed crucially depends on the onset of angiogenesis, that is, the ‘angiogenic switch’ |
| 6174- | TM, | Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse |
| - | Trial, | BC, | NA |
| 6172- | TM, | Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer |
| - | Trial, | Pca, | NA |
| 1933- | TQ, | Thymoquinone: potential cure for inflammatory disorders and cancer |
| - | Review, | Var, | NA |
| 1935- | TQ, | Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis |
| - | Review, | OS, | NA |
| 2138- | TQ, | Thymoquinone has a synergistic effect with PHD inhibitors to ameliorate ischemic brain damage in mice |
| - | in-vivo, | Nor, | NA |
| 2094- | TQ, | Cytotoxicity of Nigella sativa Extracts Against Cancer Cells: A Review of In Vitro and In Vivo Studies |
| - | Review, | Var, | NA |
| 2102- | TQ, | A review on therapeutic potential of Nigella sativa: A miracle herb |
| - | Review, | Var, | NA |
| 3559- | TQ, | Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease |
| - | Review, | AD, | NA | - | Review, | Var, | NA |
| 3571- | TQ, | The Role of Thymoquinone in Inflammatory Response in Chronic Diseases |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA |
| 3408- | TQ, | Thymoquinone: A small molecule from nature with high therapeutic potential |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3397- | TQ, | Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer |
| - | Review, | CRC, | NA |
| 3424- | TQ, | Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex |
| - | Review, | Var, | NA |
| 3425- | TQ, | Advances in research on the relationship between thymoquinone and pancreatic cancer |
| 3430- | TQ, | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
| - | Review, | Var, | NA |
| 3423- | TQ, | Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics |
| - | Review, | Var, | NA |
| 3420- | TQ, | Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway |
| - | in-vitro, | Nor, | HUVECs | - | in-vitro, | NA, | NA |
| 5904- | TV, | Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA | - | Review, | Diabetic, | NA | - | Review, | Obesity, | NA | - | Review, | AD, | NA | - | Review, | Arthritis, | NA |
| 5019- | UA, | Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions |
| - | Review, | Var, | NA |
| 5022- | UA, | Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks |
| - | Review, | Var, | NA |
| 4833- | Uro, | Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | IBD, | NA |
| 8159- | UsA, | Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity |
| - | in-vitro, | Cerv, | HeLa |
| 3151- | VitC, | Role of Vitamin C in the Function of the Vascular Endothelium |
| - | Review, | Nor, | NA |
| 4350- | VitD3, | Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:447 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid