DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.


Scientific Papers found: Click to Expand⟱
598- VitC,    Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly
- Review, NA, NA
H2O2↑, ROS↑, TET1↑, DNAdam↑, G6PD∅,
627- VitC,    High-Dose Vitamin C for Cancer Therapy
- Review, NA, NA
ROS↑, PARP↑, GAPDH↓, DNAdam↑, ATP↓,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
629- VitC,  Cu,  Fe,    The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer
- in-vitro, NA, NA
ROS↑, DNAdam↑, NAD↓,
628- VitC,  Mg,    Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
- in-vivo, Colon, CT26 - in-vitro, NA, MCF7 - in-vitro, NA, SkBr3
AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,
3138- VitC,    The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity
- in-vitro, RCC, RCC4 - in-vitro, CRC, HCT116 - in-vitro, BC, MDA-MB-435 - in-vitro, Ovarian, SKOV3 - in-vitro, Colon, SW48 - in-vitro, GBM, U251
eff↑, Warburg↓, BioAv↑, ROS↑, DNAdam↑, ATP↓, eff↑, necrosis↑, PARP↑,
3109- VitC,    Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway
- in-vitro, Lung, H1299
TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,
3104- VitC,    Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations
*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,
3128- VitC,    Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages
- in-vitro, Nor, NA
*ROS↓, *DNAdam↓, *TNF-α↓, *IL6↓, *p38↓,
2284- VitK2,    Menadione-induced DNA damage in a human tumor cell line
- in-vitro, BC, MCF7
DNAdam↑, ROS↑,
2276- VitK2,    Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat
- in-vivo, Nor, NA
*Albumin↑, *AST↓, *ALAT↓, *Keap1↓, *NRF2↑, *HO-1↑, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *TIMP1↓, *TGF-β↓, *ROS↓, *DNAdam↓, *Inflam↓,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
ROS↑, H2O2↑, NF-kB↑, P53↑, cJun↑, Casp3↑, MMP↓, DNAdam↑, Dose?,
7908- VT,    Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway
- in-vitro, AML, NA
MMP↓, DNAdam↑, BCR↓, ABL1↓, HRAS↓, NRAS↓, KRAS↓, Raf↓, p38↑, BAX↑, Casp9↑,
604- ZO,    Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications
- Review, NA, NA
ROS↑, Apoptosis↑, DNAdam↑,

Showing Research Papers: 401 to 416 of 416
Prev Page 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 416

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1)

Fenton↑, 1,   H2O2↑, 2,   HO-1↑, 1,   NRF2↑, 1,   ROS↑, 12,  

Mitochondria & Bioenergetics(tgid=3)

ABL1↓, 1,   ATP↓, 4,   BCR↓, 1,   MMP↓, 3,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4)

G6PD∅, 1,   GAPDH↓, 1,   NAD↓, 3,   Warburg↓, 1,  

Cell Death(tgid=5)

Apoptosis↑, 5,   BAX↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   proCasp3↑, 1,   pro‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   FasL↑, 1,   necrosis↑, 1,   p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7)

cJun↑, 1,   other↑, 1,   OV6↓, 1,  

Autophagy & Lysosomes(tgid=9)

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↑, 13,   P53↑, 1,   PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11)

P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12)

CD133↓, 1,   CSCs↓, 1,   EMT↓, 1,   EpCAM↓, 1,   HRAS↓, 1,   NRAS↓, 1,  

Migration(tgid=13)

KRAS↓, 1,   TET1↑, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14)

HIF-1↓, 1,  

Barriers & Transport(tgid=15)

SVCT-2↝, 1,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling(tgid=16)

NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↑, 2,   ChemoSen↑, 1,   Dose?, 1,   eff↑, 3,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22)

KRAS↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   OS↑, 1,   Risk↓, 1,   toxicity∅, 1,   TumVol↓, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1)

antiOx↑, 1,   HO-1↑, 1,   Keap1↓, 1,   NRF2↑, 1,   ROS↓, 3,  

Core Metabolism/Glycolysis(tgid=4)

ALAT↓, 1,  

Cell Death(tgid=5)

iNOS↓, 1,   p38↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↓, 3,  

Migration(tgid=13)

TGF-β↓, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 2,  

Clinical Biomarkers(tgid=22)

ALAT↓, 1,   Albumin↑, 1,   AST↓, 1,   IL6↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: DNAdam, DNA damage
31 Silver-NanoParticles
18 Radiotherapy/Radiation
17 Vitamin C (Ascorbic Acid)
12 Magnetic Fields
12 Curcumin
11 Fisetin
8 Quercetin
7 Chemotherapy
7 Cisplatin
7 Ashwagandha(Withaferin A)
7 Chrysin
7 Lycopene
7 salinomycin
7 Selenium NanoParticles
6 Artemisinin
6 Apigenin (mainly Parsley)
6 Berberine
6 Carvacrol
6 Emodin
6 Piperlongumine
6 Sulforaphane (mainly Broccoli)
5 Copper and Cu NanoParticles
5 Allicin (mainly Garlic)
5 Baicalein
5 Betulinic acid
5 Ellagic acid
5 diet FMD Fasting Mimicking Diet
5 Dandelion Root
5 Gallic acid
5 Kaempferol
5 nicotinamide adenine dinucleotide
5 Selenite (Sodium)
5 Thymoquinone
4 Auranofin
4 doxorubicin
4 Beta-Caryophyllene
4 Capsaicin
4 Thymol-Thymus vulgaris
4 Echinacea
4 Electrical Pulses
4 Ferulic acid
4 Garcinol
4 Magnetic Field Rotating
4 Vitamin B3,Niacin
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
3 chitosan
3 Anethole/trans-Anethole
3 borneol
3 Boron
3 Boswellia (frankincense)
3 Rosmarinic acid
3 Cat’s Claw
3 Cynaropicrin
3 Disulfiram
3 EGCG (Epigallocatechin Gallate)
3 Eurycomanone
3 Eugenol
3 Hibiscus sabdariffa
3 Juglone
3 Licorice
3 Lemongrass Extract/Citral
3 Magnolol
3 Nimbolide
3 Phenethyl isothiocyanate
3 α-Santalol/Sandalwood oil
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Vitamin K2
2 1,8-Cineole
2 Moringa oleifera
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Metformin
2 Melatonin
2 Astaxanthin
2 Aloe anthraquinones
2 brusatol
2 Bruteridin(bergamot juice)
2 Caffeic acid
2 Carnosic acid
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Crocetin
2 diet Short Term Fasting
2 Fucoidan
2 Gambogic Acid
2 Geraniol
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Hydrogen Gas
2 Hydroxycinnamic-acid
2 isoorientin
2 Propyl gallate
2 Ursolic acid
2 VitK3,menadione
1 3-bromopyruvate
1 5-Hydroxytryptophan
1 Astragalus
1 Gold NanoParticles
1 Photodynamic Therapy
1 entinostat
1 tamoxifen
1 Alpha-Lipoic-Acid
1 Fennel Oil/Foeniculum vulgare
1 Ascorbyl Palmitate
1 Baicalin
1 Biochanin A
1 Gemcitabine (Gemzar)
1 Bromelain
1 Black phosphorus
1 α-Bisabolol / Chamomile oil
1 buckwheat sprouts
1 Rutin
1 Zinc
1 carboplatin
1 Catechins
1 chaetocin
1 Chlorophyllin
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 chemodynamic therapy
1 Dichloroacetate
1 Deguelin
1 Diclofenac
1 Date Fruit Extract
1 D-limonene
1 immunotherapy
1 Butyrate
1 Sesame seeds and Oil
1 Formononetin
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 olaparib/LYNPARZA
1 Galloflavin
1 Germanium inorganic
1 Ginkgetin
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 Honokiol
1 Hyperthermia
1 HydroxyTyrosol
1 Isobavachalcone
1 isoquercitrin
1 Lapachol
1 Lasiodin
1 Luteolin
1 Methyl salicylate / Sweet Birch oil
1 Piperine
1 Plumbagin
1 Rauwolfia serpentina/Indian Snakeroot
1 Sulfasalazine
1 Aflavin-3,3′-digallate
1 temozolomide
1 triptolide
1 Urolithin
1 Iron
1 Magnesium
1 Vitexin
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:82  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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