Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7330- GSE,    Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
- Review, Var, NA
*BioAv↑, *ROS↓, AntiCan↑, selectivity↑, RenoP↑, *hepatoP↑, *DNAdam↓, *Stroke↓, *Bcl-2↑, cMyc↓,
7328- GSE,    Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial
- Trial, Nor, NA
*Dose↝, *BP↓, *other↝, *eff↑,
7327- GSE,    Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats
- in-vivo, CRC, NA
chemoPv↑, TumCP↓, Apoptosis↑, cycD1/CCND1↓, COX2/PTGS2↓, iNOS↓, survivin↓, β-catenin/ZEB1↓, NF-kB↓, Risk↓,
7326- GSE,    LEUCOSELECT PHYTOSOME MODULATES SERUM EICOSAPENTAENOIC ACID, DOCOSAHEXAENOIC ACID and PROSTAGLANDIN E3 IN A PHASE 1 LUNG CANCER CHEMOPREVENTION STUDY
- in-vitro, Lung, A549 - in-vitro, Lung, H520
antiNeop↑, Ki-67↓, other↑, PGE3↑,
7325- GSE,    The Effects of a Grape Seed Procyanidin Extract on Cytochrome P450 3A4 Activity and Inflammatory Mediators in the Lungs of Heavy Active and Former Smokers
- in-vitro, Lung, NA
*cardioP↑, *Inflam↓, BioAv↑, TNF-α↓, MIP‑1α/CCL3↓, GranB/GZMB↓,
7324- GSE,    A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention
- Trial, Lung, NA
BioAv↑, toxicity↝, Ki-67↓, miR-106b↓, chemoPv↑, Dose↝, miR-19b↓, PTEN↑, IGF-2R↑, p‑Akt↓, PGE2↓, PGI2↓, COX2/PTGS2↓, Apoptosis↑, TumCP↓, Inflam↓, cardioP↑,
7323- GSE,    Grape seed procyanidin extract against lung cancer: the role of microrna-106b, bioavailability, and bioactivity
- vitro+vivo, Lung, NA
miR-106b↓, P21↑, TumCG↓, Dose↝,
7322- GSE,    MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
- vitro+vivo, Lung, A549 - in-vitro, Lung, H520 - in-vitro, Lung, H1299 - in-vitro, Nor, BEAS-2B
miR-19b↓, IGF-2R↑, PTEN↑, p‑Akt↓, Dose↝,
7329- GSE,    Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers
- Trial, Nor, NA
*Dose↝, *BP↓,
1241- GSE,  PACs,    Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietin signaling
- in-vitro, Nor, NA
*VEGF↓, *MMP2↓, *MMP9↓, *p‑VEGFR2/KDR/Flk1↓,
1240- GSE,  PACs,    Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, Hs294T
TumCMig↓, TumCI↓, COX2/PTGS2↓, PGE2↓, NF-kB↓, EMT↓, E-cadherin↑, Vim↓, Fibronectin↓, N-cadherin↓,
1292- GSE,  EGCG,    Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT8
TumCG↓, Apoptosis↑,
1118- GSE,    Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF- β Signaling Pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 5637
TumCMig↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Vim↓, Slug↓, E-cadherin↑, ZO-1↑, p‑SMAD2↓, p‑SMAD3↓, p‑Akt↓, p‑ERK↓, p‑p38↓,
30- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1
HH↓, Gli1↓, Shh↓, cycD1/CCND1↓, TumCP↓,
108- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1 - in-vitro, PC, C3H10T1/2
HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,
6561- GSL,    Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *neuroP↑, *AntiCan↑, *BioAv↝, *Dose↝, *toxicity↓, *Catalase↑, *NADPH↑, *GSR↑, *ALAT∅, *AST∅,
7134- GSL,    Phase I study of oral spirogermanium
- Trial, NA, NA
*Dose↝, toxicity↝, Bil∅, toxicity↝, Dose↓,
7111- GSL,    In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens
- NA, Nor, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2/PTGS2↓, *NF-kB↓, *Inflam↓,
7485- H2,    Molecular hydrogen inhibits neuroinflammation and ameliorates depressive-like behaviors and short-term cognitive impairment in senescence-accelerated mouse prone 8 mice
- in-vivo, Nor, NA
*Dose↑, *cognitive↑, *memory↑,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
7484- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer's Disease Models
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *ROS↓, *Inflam↓, *neuroP↑, *memory↑, *Catalase↑, *TNF-α↓, *Aβ↓, *GABA↓, *H2O2↓, *GFAP↓, *antiOx↑, *NRF2↑,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓,
7486- H2,    Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
- Trial, Nor, NA
*eff↑, *uricA↓, *toxicity↓, *antiOx↑, *Inflam↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↓, *Dose↓, *ROS↓,
7488- H2,    Molecular hydrogen therapy: A "democratic" emerging strategy against aging and age-related diseases
- Review, Nor, NA
*antiOx↑, *Inflam↑, *toxicity↓, *AntiAge↑,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
7490- H2,    Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
- in-vivo, Diabetic, NA
*BG↓, *AntiDiabetic↑, *BMD↑, *hepatoP↑, *RenoP↑, *QoL↑,
7491- H2,    Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles
- in-vivo, PSA, NA
*Dose↝, *ROS↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓,
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, *Airway↓, *BALF-Infl↓, *Th2↓, *IL4↓, *IgE↓, *MDA↓, *SOD↑, *NF-kB↓, *NRF2↑,
7927- H2,    Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
- Human, Asthma, NA
*IL8↓, *IL4↓, *IL6↓, *Inflam↓, *Sepsis↓, *Stroke↓, *antiOx↑, *toxicity↓,
7928- H2,    Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis
- in-vivo, Asthma, NA
*IL33↓, *NF-kB↓, *IL1RL1/ST2↓, *ILC2↓, *E-cadherin↑, *ZO-1↑, *Inflam↓,
7929- H2,    Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
- NA, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *TNF-α↓, *AirwayM↓, *MUC5AC↓, *COL3A1↓, *VEGF↓, *NF-kB↓, *Inflam↓,
7930- H2,    Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation
- in-vivo, Asthma, NA
*GutMicro↑, *Inflam↓, *Dose↝, *AirwayM↓,
7931- H2,    Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells
- in-vitro, Asthma, NA
*p‑FcεRI↓, *NADPH↓, *H2O2↓, *Dose↝,
7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, *antiOx↑, *Eos↓, *BALF-Infl↓, *IL5↓, *IL13↓, *CCL11↓,
7933- H2,    Hydrogen inhalation ameliorates lung inflammation in mice with asthma
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *IL4↓, *IL5↓, *IL13↓, *IL10↑, *TGF-β1↑, *IgE↓, *MDA↓, *SOD↑, *Airway↓,
4343- H2,    Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation
- vitro+vivo, NA, NA
*antiOx↑, *AntiAg↑, *NO↑, *ERK↑,
4344- H2,    Hydrogen May Inhibit Collagen-Induced Platelet Aggregation: An ex vivo and in vivo Study
- in-vivo, NA, NA - ex-vivo, NA, NA
*AntiAg↑,
4347- H2,    Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study
- ex-vivo, NA, NA
*AntiAg↑,
4346- H2,    Medical Application of Hydrogen in Hematological Diseases
- Review, NA, NA
*AntiAg↑, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓,
4345- H2,    The Benefit of Hydrogen Gas as an Adjunctive Therapy for Chronic Obstructive Pulmonary Disease
- Human, NA, NA
*Inflam↓, *antiOx↑, *ROS↓, *NLRP3↑, *NF-kB↓, *SOD↑, *Catalase↑, *AntiAg↑,
4237- H2,    Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats
- in-vitro, NA, NA
*Apoptosis↓, *ROS↓, *motorD↑, *BDNF↑,
4236- H2,    Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *BDNF↑, *Casp3↓,
4235- H2,    PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression
- in-vivo, Sepsis, NA
*PPARα↑, *CREB↑, *BDNF↑, *OS↑, *cognitive↑,
4234- H2,    Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice
- in-vivo, Sepsis, NA
*cognitive↑, *DNMT1↓, *DNMT3A↓, *BDNF↑,
4306- H2,    Molecular Hydrogen as an Emerging Candidate for Preventing Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *memory↑, *neuroP↑, *OS↑, *Inflam↓,

Showing Research Papers: 4451 to 4500 of 8269
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BHB↑, 1,   CD47↓, 1,   HMGCS2↑, 1,   IGF-2R↑, 2,   miR-106b↓, 2,   miR-124-3p↓, 1,   NLR↓, 1,   PFS↑, 1,   PGE3↑, 1,   PGI2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Bil∅, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   SCD1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 3,   Apoptosis↑, 4,   Casp3↑, 1,   GranB/GZMB↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   p‑p38↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   other↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 3,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   p‑ERK↓, 1,   Gli1↓, 2,   HH↓, 2,   PI3K↓, 1,   PTEN↑, 2,   Shh↓, 1,   TumCG↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 2,   Fibronectin↓, 1,   Ki-67↓, 2,   MALAT1↓, 1,   miR-19b↓, 2,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 2,   Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 5,   Vim↓, 2,   ZO-1↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CRP↓, 1,   IL6↓, 1,   Inflam↓, 2,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   PGE2↓, 2,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 3,   Dose↓, 1,   Dose↝, 6,   eff↑, 2,   eff∅, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

Bil∅, 1,   CRP↓, 1,   EZH2↓, 1,   IL6↓, 1,   Ki-67↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum∅, 1,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 2,   NP/CIPN↓, 1,   QoL↑, 2,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 1,   toxicity↝, 3,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 96

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 3,   AirwayM↓, 3,   BALF-Infl↓, 3,   BALF-Lym↓, 1,   CCL11↓, 1,   compII↑, 1,   CXCL15↓, 1,   Eos↓, 3,   p‑FcεRI↓, 1,   GFAP↓, 1,   IgE↓, 4,   IL13↓, 5,   IL1RL1/ST2↓, 1,   ILC2↓, 1,   MUC5AC↓, 1,   NLR↓, 1,   SpO2↑, 1,   Stress↓, 1,   Stroke↓, 4,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 6,   Fenton↓, 1,   GPx↑, 3,   GSH↑, 1,   GSR↑, 1,   H2O2↓, 2,   HDL↑, 1,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 6,   MFN2↑, 1,   MPO↓, 3,   NOX4↓, 1,   NRF2↑, 5,   RNS↓, 1,   ROS↓, 15,   SOD↑, 8,   TAC↑, 1,   TBARS↓, 2,   uricA↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   compIII↑, 1,   MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   ALAT∅, 1,   BUN↓, 2,   CREB↑, 1,   KeyT↝, 1,   LDL↓, 2,   NADPH↓, 2,   NADPH↑, 1,   PPARα↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   Apoptosis↓, 3,   Bcl-2↑, 2,   Bcl-xL↑, 1,   Casp12↓, 1,   Casp3↓, 3,   Casp9↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   p38↓, 1,   p‑p38↓, 1,   TUNEL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↑, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↑, 2,   STAT3↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   APP↓, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 2,   MMP2↓, 1,   MMP9↓, 1,   TGF-β↑, 1,   TGF-β1↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   NO↓, 2,   NO↑, 1,   VEGF↓, 2,   p‑VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 1,   FOXP3↑, 1,   GM-CSF↓, 1,   HMGB1↓, 1,   IFN-γ↓, 2,   IL10↑, 3,   IL1β↓, 3,   IL2↓, 1,   IL33↓, 1,   IL4↓, 7,   IL4↑, 1,   IL5↓, 4,   IL6↓, 6,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 20,   Inflam↑, 1,   JAK2↑, 1,   LPS↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 2,   Neut↓, 1,   NF-kB↓, 8,   PGE2↓, 2,   Th2↓, 1,   TLR4↓, 1,   TNF-α↓, 9,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 4,   GABA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,   NLRP3↓, 2,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 2,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 18,   eff↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT∅, 1,   AST↓, 2,   AST∅, 1,   BG↓, 1,   BMD↑, 1,   BP↓, 2,   creat↓, 3,   GutMicro↑, 3,   IL6↓, 6,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 4,   chemoP↑, 1,   cognitive↑, 5,   hepatoP↑, 6,   memory↑, 3,   motorD↑, 1,   neuroP↑, 6,   Obesity↓, 2,   OS↑, 3,   QoL↑, 1,   RenoP↑, 2,   toxicity↓, 8,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  
Total Targets: 184

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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