Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7369- HibSad,    Components in aqueous Hibiscus rosa-sinensis flower extract inhibit in vitro melanoma cell growth
- in-vitro, Melanoma, B16-BL6 - in-vitro, Nor, LA25
TumCG↓, selectivity↑, Dose↝, eff↑,
7367- HibSad,  CUR,  Moringa,  CAP,  RosA  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases
- Review, Nor, NA
*ACE/ACE1↓,
7366- HibSad,    Does consumption of an aqueous extract of Hibscus sabdariffa affect renal function in subjects with mild to moderate hypertension?
- Human, Nor, NA
*creat↓, *RenoP↑,
7365- HibSad,    Insight into the molecular evidence supporting the remarkable chemotherapeutic potential of Hibiscus sabdariffa L
- Review, Var, NA
chemoPv↑, selectivity↑, TumCCA↑, Apoptosis↑, TumAuto↑, TumMeta↓, ATG5↑, Beclin-1/ATG6↑, LC3II↑, MMP2↓, MMP9↓, CD31/PECAM-1↓, VEGF↓, uPA↓, TIMP2↑, NF-kB↓, p38↑, P53↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑, Cyt‑c↑, TNF-α↑, Fas↑, FasL↑, JNK↑, cJun↑, angioG↓, VEGFR2/KDR/Flk1↓, PCNA↓, CCN2/CTGF↓, RAGE↓,
7364- HibSad,    Hibiscus sabdariffa calyx extract induces anti-proliferative and anti-migratory effects in ovarian cancer
- in-vitro, Ovarian, OVCAR-3
*Inflam↓, *AntiBio↑, *antiOx↑, TumCMig↓, AKT1↓, cycD1/CCND1↓,
7363- HibSad,    Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation
Apoptosis↑, selectivity↑, p‑p38↑, JNK↑, cJun↑, Cyt‑c↑, Fas↑, FasL↑,
7362- HibSad,    The effect of a water extract and anthocyanins of hibiscus sabdariffa L on paracetamol-induced hepatoxicity in rats
- in-vivo, Nor, NA
*Dose↝, *hepatoP↑,
7361- HibSad,    Hibiscus sabdariffa L. - a phytochemical and pharmacological review
- Review, Var, NA
*Bacteria↓, *hepatoP↑, *diuretic↑, *LDL↓, *antiOx↑, *ACE/ACE1↓, *Ca+2↝, *toxicity↓, *ROS↓, *RenoP↑,
7360- HibSad,    Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa
- Study, Nor, NA
*diuretic↑, *BP↓, *ACE/ACE1↓,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7357- HibSad,    Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells
- in-vitro, CRC, LoVo
Apoptosis↑, AMPK↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑Casp3↑, Dose↝, mtDam↑, MMP↓, Akt↓,
7356- HibSad,    Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
AntiCan↑, Apoptosis↑, selectivity↑, ChemoSen↑, ROS↑, MMP↓, eff↑,
7355- HibSad,    Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, ER-α36↓, BRCA1↓, Cav1↓, Proteasome↓, TumAuto↑, TumCMig↓, TumCI↓,
7354- HibSad,    Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway
- vitro+vivo, Pca, LNCaP
MMP9↓, NF-kB↓, Akt↓, TumVol↓, PI3K↓, *antiOx↑, Dose↝,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,
7352- HibSad,    Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis
- Review, Nor, NA
*BP↓, *toxicity↓,
7351- HibSad,    Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression
- in-vitro, AML, HL-60
tumCV↓, DNAdam↑, RB1↓, Bcl-2↓, BAX↑,
7350- HibSad,    Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway
- in-vitro, GC, AGS
TumCD↑, DNAdam↑, P53↑, Bcl-2↓, Mcl-1↓, Cyt‑c↑, FasL↑, Fas↑, p38↑, BAX↑, Dose↝, TumCCA↑,
7349- HibSad,    Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract
- Trial, Nor, NA
*Dose↝, *Half-Life↓, *Half-Life↝, *BioAv↓, *antiOx↑, *BioAv↓,
1160- HibSad,    Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation
- Analysis, NA, NA
ER(estro)↓,
7348- Hne,    Apoptosis‐inducing activity of Helleborus nigerin ALL and AML
- in-vitro, AML, NA
TumCP↓, Casp3↑,
7347- Hne,    Study of potent cytotoxic activity of Helleborus cyclophyllus Boiss against a human adenocarcinoma cell line
- NA, Lung, A549
tumCV↓, selectivity↑, pro‑Casp3↓, cl‑PARP1↑,
7346- Hne,    Subcutaneous application of Helleborus niger 12x in older patients with dementia-a retrospective cohort study
- Trial, AD, NA
*cognitive↑,
7345- Hne,    A root extract of Helleborus niger possess cytotoxic properties in neuroblastoma cells
- in-vitro, neuroblastoma, NXS2
TumCP↓, Casp8↑, Casp9↑, Ca+2↑,
7344- Hne,    Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy
- in-vitro, Cerv, HeLa
tumCV↓, ROS↑, eff↓, TumAuto↓,
7343- Hne,    Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer
- in-vitro, Melanoma, A431 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HaCaT - in-vitro, Nor, JB6
*Dose↝, *antiOx↑, selectivity↑, Bcl-2↓, BAD↑, BAX↑,
7341- Hne,    Preclinical evaluation of safety and potential of black hellebore extracts for cancer treatment
- Review, Var, NA
angioG↓, TumCP↓, *Inflam↓, *Bacteria↓, *glucose↓, *neuroP↓, *hepatoP↓, *Imm↝,
7340- Hne,    Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells
- in-vitro, AML, NA
TumCP↓, Apoptosis↑, selectivity↑,
7339- Hne,    Apoptosis-inducing activity of Helleborus niger in ALL and AML
- in-vitro, AML, NA
TumCP↓, DNAdam↓, Casp3↑, MMP↓, eff↑, Apoptosis↑,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
7467- HNK,    Honokiol regulates ovarian cancer cell malignant behavior through YAP/TAZ pathway modulation
- vitro+vivo, Oral, NA
tumCV↓, TumCP↓, TumCMig↓, TumCI↓, YAP/TEAD↓, TAZ↓, TumCG↓,
7466- HNK,  PDT,  MET,    Enhanced integrated therapy for breast cancer employing Honokiol-loaded mesoporous polydopamine nanoparticles in conjunction with photothermal effects and low-dose metformin
- in-vitro, BC, NA
TumCD↓, Dose↝, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑, TumCP↓,
7465- HNK,    Aptamer-modified GSH-degradable honokiol polyprodrug nanoparticles for ovarian cancer-specific targeting therapy
- in-vitro, Ovarian, NA
Dose↝, eff↑,
7464- HNK,    Bioinformatics and In Vitro Study Reveal ERα as The Potential Target Gene of Honokiol to Enhance Trastuzumab Sensitivity in HER2+ Trastuzumab-Resistant Breast Cancer Cells
- in-vitro, BC, HCC1954
tumCV↓, ChemoSen↑,
7463- HNK,    Honokiol Inhibits Colorectal Cancer Cell Growth: Involvement of Hsp27 as a Molecular Target
- in-vitro, CRC, NA
TumCG↓, TumCCA↑, Cyt‑c↑, Apoptosis↑, cl‑PARP↑, Bcl-2↓, HSP27↓,
7461- HNK,    Honokiol: a potent chemotherapy candidate for human colorectal carcinoma
- vitro+vivo, CRC, RKO
Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,
7460- HNK,    Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lb MPMs) for Improving Solubility to Enhance Oral Bioavailability
- in-vivo, Nor, NA
BioAv↝, BioAv↝,
7459- HNK,    Honokiol Exhibits Anti-Tumor Effects in Breast Cancer by Modulating the miR-148a-5p-CYP1B1 Axis
- in-vitro, BC, MDA-MB-231
TumCP↓, Apoptosis↓, TumCMig↓, CYP1B1↓, ChemoSen↑,
7458- HNK,    Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2
- in-vitro, Ovarian, OVCAR-3
TumCP↓, TumCI↓, Ferroptosis↑, YAP/TEAD↓, OTUB2↓,
7457- HNK,    Honokiol enhances the sensitivity of cetuximab in KRASG13D mutant colorectal cancer through destroying SNX3-retromer complex
- in-vitro, CRC, NA
ChemoSen↑,
7456- HNK,    Honokiol in the treatment of triple-negative breast cancer: a network pharmacology approach and experimental validation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Apoptosis↑, TumCMig↓, TumCP↓, HSP90↓, AKT1↓, EGFR↓, HSP90↓, MDM2↓, HDAC1↓,
7455- HNK,    Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies
- Review, Var, NA
ChemoSen↑, Imm↝, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiCan↑, *Inflam↓, *antiOx↑, eff↑, *TNF-α↓, *IL1?, *IL6?,
7454- HNK,    Updated progression of honokiol in lung cancer treatment
- Review, Lung, NA
AntiCan↑, eff↑,
7453- HNK,    Determination of Potential Lead Compound from Magnolia officinalis for Alzheimer's Disease through Pharmacokinetic Prediction, Molecular Docking, Dynamic Simulation, and Experimental Validation
- Study, AD, NA
*BACE/β-secretase↓, *AChE↓, *QPCT/QC↓, *GSK‐3β↓, *toxicity↓,
2874- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6‐mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
MMP9↓, α-tubulin↑, TumCI↓, HDAC6↓, HSP90↓, TumCMig↓, EGFR↓,
2875- HNK,    Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
- in-vitro, Lung, A549 - in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, SCC, H226
HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,
2876- HNK,    Honokiol from Magnolia spp. induces G1 arrest via disruption of EGFR stability through repressing HDAC6 deacetylated Hsp90 function in lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Lung, H23 - in-vitro, Lung, HCC827
EGFR↓, HSP90↓,
2877- HNK,    Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer
- in-vitro, GC, AGS
HDAC3↓, NF-kB↓, CEBPB↓, ER Stress↑, EMT↓, Wnt↓, β-catenin/ZEB1↓,
2878- HNK,    Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
- in-vitro, Lung, H1299
TumCMig↓, TumCI↓, MMP9↓, α-tubulin↑, HDAC6↓, HSP90↓,
2879- HNK,    Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function
- in-vitro, Lung, H226 - in-vivo, NA, NA
tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,

Showing Research Papers: 4601 to 4650 of 8269
Prev Page 93 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

OTUB2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   ROS↑, 3,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mitResp↓, 1,   MMP↓, 5,   mtDam↑, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 2,   AMP↑, 1,   AMPK↑, 3,   Cav1↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 12,   BAD↑, 2,   BAX↑, 6,   Bcl-2↓, 8,   Bcl-xL↓, 2,   Casp↑, 1,   cl‑Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   pro‑Casp3↓, 1,   Casp7↑, 2,   Casp8↑, 4,   Casp9↑, 4,   Cyt‑c↑, 6,   Fas↑, 5,   FasL↑, 4,   Ferroptosis↑, 1,   JNK↑, 2,   Mcl-1↓, 1,   MDM2↓, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   p‑p38↑, 1,   Proteasome↓, 1,   TumCD↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   ac‑H3↑, 1,   ac‑H4↑, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP27↓, 1,   HSP90↓, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CYP1B1↓, 1,   DNAdam↓, 1,   DNAdam↑, 3,   P53↑, 3,   cl‑PARP↑, 2,   cl‑PARP1↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↑, 1,   RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPB↓, 1,   CSCs↓, 1,   EMT↓, 2,   Gli1↓, 1,   HDAC↓, 1,   HDAC1↓, 2,   HDAC3↓, 2,   HDAC6↓, 2,   HH↓, 1,   miR-34a↑, 1,   PI3K↓, 2,   PTCH1↓, 1,   RAS↓, 1,   Shh↓, 1,   p‑STAT3↓, 1,   TAZ↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 1,   ER-α36↓, 1,   MMP2↓, 2,   MMP9↓, 4,   RAGE↓, 1,   TIMP2↑, 1,   TumCI↓, 6,   TumCMig↓, 8,   TumCP↓, 12,   TumMeta↓, 1,   uPA↓, 1,   α-tubulin↑, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 3,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Imm↝, 1,   NF-kB↓, 5,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 6,   Dose↝, 7,   eff↓, 1,   eff↑, 6,   Half-Life↝, 1,   selectivity↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   EGFR↓, 3,   IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   chemoPv↑, 1,   OS↑, 1,   TumVol↓, 1,  
Total Targets: 134

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 3,   AntiBio↑, 2,   diuretic↑, 2,   QPCT/QC↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   ROS↓, 3,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,   LDL↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1?, 1,   IL6?, 1,   Imm↝, 1,   Inflam↓, 6,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   Dose↝, 3,   Half-Life↓, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 3,   creat↓, 1,   IL6?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 3,   neuroP↓, 1,   neuroP↑, 1,   RenoP↑, 2,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 40

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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