Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4239- HNK,    Honokiol reverses depressive-like behavior and decrease in brain BDNF levels induced by chronic corticosterone injections in mice
- in-vivo, NA, NA
*Mood↑, *BDNF↑,
4240- HNK,    Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity
- in-vivo, NA, NA
*BDNF↑,
4238- HNK,    Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
- Review, AD, NA - NA, Park, NA
*BDNF↑, *hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *SIRT3↑, *Aβ↓, *Apoptosis↓, *ROS↓, *MMP↑, *Ca+2↓, *Casp3↓, *Ach↑, *PPARγ↑, *PGC-1α↑, *motorD↑, *TNF-α↓, *IL1β↓,
4241- HNK,    Effects of Honokiol on Neurological Injury and Cognitive Function in Mice with Intracerebral Hemorrhage by Regulating BDNF-TrkB-CREB Signaling Pathway
- in-vivo, Stroke, NA
*Apoptosis↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
4522- HNK,  MAG,    Honokiol Is More Potent than Magnolol in Reducing Head and Neck Cancer Cell Growth
- in-vitro, HNSCC, FaDu
AntiCan↑, tumCV↓, eff↑, survivin↓, RadioS↑,
4688- HNK,    Honokiol Suppresses Renal Cancer Cells’ Metastasis via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling
- vitro+vivo, RCC, A498
CSCs↓, EMT↓, TumCG↓, PI3K↓, Akt↓, mTOR↓, p‑Akt↓, PTEN↑, Wnt↓, β-catenin/ZEB1↓,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,
7374- HOO,    Exploring Ozonated Vegetable Oils as Antimicrobial and Functional Agents in Food Systems: A Systematic Narrative Review
- Review, Nor, NA
*AntiBio↑, *eff↝, *Half-Life↝, *eff↑, *Phen↑, *antiOx↑, eff↝, eff↝,
7373- HOO,    Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial
- Trial, Diabetic, NA
*Wound Healing↑, *QoL↑,
7372- HOO,    Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- in-vitro, Pca, PC3
Apoptosis↑, AntiDiabetic↑, Obesity↑, TumCCA↑, other↝,
7371- HOO,    Phytochemical characterization of peanut oil and its ozonized form to explore biological activities in vitro
Dose↝, AntiBio↑, antiOx↑, AntiCan↑, selectivity↑,
7469- Hops,    CHEMOPREVENTIVE PROPERTIES OF SPENT HOPS (HUMULUS LUPULUS L.) EXTRACT AGAINST ANGIOGENESIS, INVASION AND MIGRATION OF COLORECTAL CANCER CELLS
- in-vitro, CRC, SW48 - in-vitro, CRC, HT29
angioG↓, TumCI↓, TumCMig↓, MMP2↓, MMP9↓, VEGF↓, Hif1a↓, chemoPv↑,
7470- Hops,    Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A)
- NA, Nor, MCF10
*CYP1A1↓, *CYP1B1↓,
7471- Hops,    Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages
- in-vitro, Nor, RAW264.7
*IL6↓, *COX2/PTGS2↓, *iNOS↓, *NO↓, *NF-kB↓, *Inflam↓,
7472- Hops,    Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids
- in-vitro, BC, SkBr3
CYP19↓, TumCP↓, Apoptosis↑, AntiCan↑,
7675- HPT,    Quality assurance protocol for superficial and deep hyperthermia systems established by the Hellenic Association of Medical Physicists (HAMP) in cooperation with the Hellenic Society of Oncologic Hyperthemia (HSOH): A study based on European Society for Hyperthermic Oncology (ESHO) quality assurance guidelines
- Review, Var, NA
NA↝,
7651- HPT,  Rad,    Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner
- in-vitro, Var, NA
RadioS↑, DNArepair↓, Dose↑,
7650- HPT,    Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer
- Trial, BC, NA
OS↑, LC↑,
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7598- HPT,  Rad,  Chemo,    The role of capacitive hyperthermia as an adjunct treatment in oncology: a systematic review of randomized phase III trials
- Review, Var, NA
OS↑, TR↑, LC↑, *toxicity?,
7618- HPT,    ESHO 2-85. Hyperthermia as an adjuvant to radiation therapy in the treatment of advanced neck nodes: A randomized multicenter study by the European Society for Hyperthermic Oncology
ORR↑, NA↑, NA↑, BioAv↝, Dose↝, Dose↝,
7619- HPT,    The role of hyperthermia in the treatment of tumor
Imm↑, RadioS↑, ChemoSen↑, EPR↑,
7620- HPT,    Hyperthermia and radiotherapy: physiological basis for a synergistic effect
- Review, Var, NA
RadioS↑, DNArepair↓, Hypoxia↓, CSCs↓, Imm↑, pH↝, HSPs↑, ROS↑, eff↑,
7571- HPT,    Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
- vitro+vivo, Var, NA
BRCA2↓, eff↑, RadioS↑,
7621- HPT,  Rad,    Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone in patients with painful bony metastases: A phase III clinical trial study
- Trial, Pca, NA - Trial, BC, NA
Pain↓, Dose↝, CR↑,
7622- HPT,    A Review of the Current Clinical Evidence for Loco-Regional Moderate Hyperthermia in the Adjunct Management of Cancers
- Review, Var, NA
LC↑, OS↑, QoL↑, toxicity↓, Dose↝, Dose↝, ROS↑, DNArepair↓, EPR↑, DNAdam↑, HSP70/HSPA5↑, BloodF↑, Hypoxia↓,
7597- HPT,    Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group
- Trial, Var, NA
ORR↑, OS↑,
7577- HPT,  Rad,    Randomized trial of hyperthermia and radiation for superficial tumors
- Trial, Var, NA
RadioS↑, eff↑, Dose↝,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
7574- HPT,  Oxy,    Improvement of tumor oxygenation by mild hyperthermia
Hypoxia↓, OCR↓, RadioS↑, eff↑, Dose↝,
7573- HPT,  Rad,    Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies
- vitro+vivo, NA, NA
RadioS↑, BRCA2↓,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7623- HPT,  Rad,    Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i
- Review, Var, NA
BRCA2↓, RadioS↑, eff↑,
7624- HPT,  Chemo,    A multicentre randomised clinical trial of chemoradiotherapy plus hyperthermia versus chemoradiotherapy alone in patients with locally advanced cervical cancer
- Trial, Cerv, NA
OS↑, CR↑, *toxicity↓,
7627- HPT,  Rad,    Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients
CR↑, OS↑, *toxicity↝, RadioS↑,
7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, NA, NA
BRCA2↓, selectivity↑, RadioS↑, eff↝,
5054- HPT,    Induction of Oxidative Stress by Hyperthermia and Enhancement of Hyperthermia-Induced Apoptosis by Oxidative Stress Modification
- Review, Var, NA
eff↓, ROS↑, Apoptosis↑,
5053- HPT,  Rad,  Chemo,    Association of elevated reactive oxygen species and hyperthermia induced radiosensitivity in cancer stem-like cells
- in-vitro, Var, NA
CSCs↓, TumCP↓, ROS↑, RadioS↑,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
5051- HPT,  doxoR,    Hyperthermia Enhances Doxorubicin Therapeutic Efficacy against A375 and MNT-1 Melanoma Cells
- in-vitro, Melanoma, A375
tumCV↓, TumCCA↑, ROS↑, eff↑,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
5050- HPT,    Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review
- Review, Nor, NA
*ROS↑, *SOD1↓, *GSH↓, other↑, HIF-1↑, ROS↑,
886- HPT,    Impact of hyper- and hypothermia on cellular and whole-body physiology
- Analysis, NA, NA
MMP↓, OXPHOS↓, ATP↓, ROS↑, Apoptosis↑, Cyt‑c↑,
7475- HRT,    Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial
- Review, Lung, NA
Risk↝,
7473- HRT,    Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women’s Health Initiative Randomized Clinical Trials
- Review, BC, NA
Risk↓,
7474- HRT,    Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
- Review, BC, NA
Risk↑,
7476- HRT,    Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study
- Review, Nor, NA
*cognitive↓,
7477- HRT,    Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis
- Trial, Nor, NA
*Dose↝, *memory∅, *cognitive∅,

Showing Research Papers: 4701 to 4750 of 8269
Prev Page 95 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   CR↑, 3,   LC↑, 4,   NA↑, 3,   NA↝, 1,   ORR↑, 2,   TR↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   OXPHOS↓, 1,   ROS↑, 10,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,   mtDam↑, 1,   OCR↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 7,   Bak↑, 1,   BAX↓, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   proCasp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 3,   cl‑GSDME↑, 1,   Pyro↑, 1,   survivin↓, 2,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↑, 2,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA2↓, 5,   DNAdam↑, 1,   DNArepair↓, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 4,   EMT↓, 2,   mTOR↓, 1,   PI3K↓, 1,   PTEN↑, 1,   TOP2↓, 1,   TumCG↓, 2,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   cal2↑, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EPR↑, 3,   HIF-1↑, 1,   Hif1a↓, 1,   Hypoxia↓, 6,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 5,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 2,   e-pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 2,   Dose↑, 1,   Dose↝, 12,   eff↓, 1,   eff↑, 8,   eff↝, 3,   RadioS?, 1,   RadioS↑, 15,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 5,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   chemoPv↑, 1,   Obesity↑, 1,   OS↑, 7,   Pain↓, 1,   QoL↑, 1,   Risk↓, 1,   Risk↑, 1,   Risk↝, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 97

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   CYP1A1↓, 1,   GSH↓, 1,   ROS↓, 1,   ROS↑, 1,   SIRT3↑, 1,   SOD1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   CREB↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3↓, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

CYP1B1↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 4,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↓, 1,   cognitive↑, 1,   cognitive∅, 1,   hepatoP↑, 1,   memory∅, 1,   Mood↑, 1,   motorD↑, 1,   QoL↑, 1,   toxicity?, 1,   toxicity↓, 2,   toxicity↝, 1,   Wound Healing↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Phen↑, 1,  
Total Targets: 49

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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