Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
7478- HRT,    Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Systematic Review to Update the 2002 and 2005 U.S. Preventive Services Task Force Recommendations
- Review, BC, NA
*Stroke↑, Risk⇅, *cognitive↓,
7524- HT,    The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics
- Trial, Nor, NA
*Dose↝, *BioAv↝, *Half-Life↝, *toxicity↓, *BioAv↝, *BioAv↝,
7543- HT,    Hydroxytyrosol supplementation increases vitamin C levels in vivo. A human volunteer trial
- Trial, Nor, NA
VitC↑,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
7540- HT,    Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation
- in-vitro, CRC, HCT8 - in-vitro, CRC, HCT116
TrxR1↑, ROS↑, TumCP↓, Apoptosis↑, TumCCA↑, Dose↝, eff↓,
7525- HT,    Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans
- Human, Nor, NA
*BioAv↑, *BioAv↑,
7526- HT,    Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans
- Trial, Nor, NA
*Half-Life↝, *BioAv↑, *Dose↝, *BioAv↝,
7527- HT,    Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation
- vitro+vivo, NA, HT29 - in-vitro, NA, Caco-2
EGFR↓, TumCP↓, TumCG↓,
7528- HT,    Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
- NA, NA, Jurkat - NA, NA, HL-60 - NA, NA, RAW264.7
*antiOx↑, *Inflam↓, *AntiBio↑, *cardioP↑, AntiCan↑, TumCCA↑, PI3K↓, MAPK↑, ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, p‑P53↓,
7529- HT,    Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *TNF-α↓, *neuroP↑,
7530- HT,    The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease
- in-vivo, AD, NA
*Learn↑, *Copper↓,
7531- HT,  OLE,    Olive Components (Biophenols or Polyphenols) in Neurodegenerative Disease Models and Clinical Studies: A Systematic Review of Evidence and Translational Barriers
- Review, AD, NA
*Aβ↑, *cognitive↑, *antiOx↑, *Inflam↓, *neuroP↑,
7535- HT,    Hydroxytyrosol acetate from olive leaves (Olea Europaea L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line
- in-vitro, Liver, Bel-7402
TumCP↓, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, Apoptosis↑,
7536- HT,    Effects of Desert Olive Tree Pearls Containing High Hydroxytyrosol Concentrations on the Cognitive Functions of Middle-Aged and Older Adults
- Trial, AD, NA
*Dose↑, *motorD↑, *cognitive↑, *Dose↝,
7537- HT,    Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1 α Signaling
- in-vitro, Nor, PC12
*ROS↓, *mtDam↓, *PI3K↑, *Akt↑, *mTOR↑, *Hif1a↑,
7538- HT,    An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans
- in-vivo, AD, NA
*ROS↓, *Aβ↓,
7539- HT,    Polyphenols Extracts from Oil Production Waste Products (OPWPs) Reduce Cell Viability and Exert Anti-Inflammatory Activity via PPARγ Induction in Colorectal Cancer Cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo
tumCV↓, Apoptosis↑, TumCCA↑, p‑NF-kB↑, TNF-α↑, IL8↓, PPARγ↑, Inflam↓, Dose↝,
7541- HT,    Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer
- Trial, BC, NA
Dose↝, MMP9↓, TIMP1↓,
601- HT,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, JNK↑, TNF-α↓, PPP2R1A↑,
4635- HT,    Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer
- Trial, BC, NA
*Wnt↓, *NOTCH↓, *ROS↓, TumCP↓, CSCs↓,
4636- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/ß-catenin and TGFß signaling
- in-vitro, BC, SUM159 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, BC, BT549
Wnt↓, β-catenin/ZEB1↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, TGF-β↓, CSCs↓, TumCMig↓, chemoP↑,
4637- HT,    Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vitro, Pca, PC3
selectivity↑, TumCMig↓, p‑Akt↓, ROS↑, CSCs↓, CD44↓, TumCP↓,
4638- HT,    Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation
- in-vitro, CRC, DLD1 - NA, NA, 1-
selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
4640- HT,    The anti-cancer potential of hydroxytyrosol
- Review, Var, NA
selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
4642- HT,    Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
- in-vitro, HCC, HepG2 - NA, NA, Hep3B - NA, NA, SK-HEP-1
TumCP↓, TumCCA↑, Apoptosis↑, Akt↓, NF-kB↓, TumCG↓, angioG↓,
4644- HT,    The Hydroxytyrosol Induces the Death for Apoptosis of Human Melanoma Cells
- in-vitro, Melanoma, NA
tumCV↓, Apoptosis↑, P53↑, γH2AX↑, Akt↓, ROS↑, DNAdam↑,
4645- HT,    Hydroxytyrosol: Bioavailability, toxicity, and clinical applications
- Review, NA, NA
*antiOx↑, *Inflam↓, AntiTum↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↓,
4634- HT,    Hydroxytyrosol in cancer research: recent and historical insights on discoveries and mechanisms of action
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, chemoP↑,
4633- HT,    Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
- in-vitro, BC, NA
AntiCan↑, CSCs↓, antiOx↑, NQO1↑, TumCCA↑, ER Stress↑, Apoptosis↑, UPR↑,
4632- HT,    Hydroxytyrosol inhibits cancer stem cells and the metastatic capacity of triple-negative breast cancer cell lines by the simultaneous targeting of epithelial-to-mesenchymal transition, Wnt/β-catenin and TGFβ signaling pathways
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, SUM159
CSCs↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Wnt↓, p‑LRP6↓, LRP6↓, cycD1/CCND1↓, EMT↓, Slug↓, Zeb1↓, Snail↓, Vim↓, SMAD2↓, SMAD3↓, TGF-β↓,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, *AChE↓, *Ach↑, *memory↑, *NGF↑, *BDNF↑,
4211- Hup,    Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
- in-vitro, NA, NA
*memory↑, *p‑Akt↑, *BACE/β-secretase↓, *cognitive↑,
7479- Hup,    A phase II trial of huperzine A in mild to moderate Alzheimer disease
- Trial, AD, NA
*Dose↝, *cognitive↑, *eff∅, *AChE↓,
7480- Hup,    Pharmacokinetics of huperzine A following oral administration to human volunteers
- Trial, AD, NA
*Dose↝, *BioAv↝, *Half-Life↝,
3805- Hup,    Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China
- Analysis, AD, NA
*AChE↓,
3804- Hup,    Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
- Review, AD, NA
*cognitive↑, *cognitive∅, *AChE↓,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE/β-secretase↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
3802- Hup,    New insights into huperzine A for the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑,
3801- Hup,    An update on huperzine A as a treatment for Alzheimer's disease
- Review, AD, NA
*AChE↓, *antiOx↑, *neuroP↑,
3800- Hup,    Role of huperzine a in the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑, *cognitive↑,
3799- Hup,    The use of Huperzia species for the treatment of Alzheimer's disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *AChE↓,
7570- HYP,    Hyperoside suppresses BMP-7-dependent PI3K/AKT pathway in human hepatocellular carcinoma cells
- in-vitro, Liver, HepG2
TumCCA↑, TumCP↓, BMP7/OP1↓, p‑Akt↓, PI3K↓,
7569- HYP,    Inhibitory effects of hyperoside on lung cancer by inducing apoptosis and suppressing inflammatory response via caspase-3 and NF-κB signaling pathway
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, Casp3↑, Apoptosis↑, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL18↓, TumVol↓, TumW↓,
7557- HYP,    Hyperoside protects the blood-brain barrier from neurotoxicity of amyloid beta 1-42
- in-vitro, AD, NA
*neuroP↑, *Aβ↓, *Casp3↑, *ZO-1↓, *CLDN5↓, *OCLN↓, *MMP2↑, *MMP↓,
7568- HYP,  PacT,    Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling
- in-vitro, BC, MDA-MB-231
Inflam↓, AntiTum↑, selectivity↑, chemoP↑, TumCI↓, ChemoSen↑, tumCV↓, Apoptosis↑, Casp3↑, TLR4↓, NF-kB↓,

Showing Research Papers: 4751 to 4800 of 8269
Prev Page 96 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   NQO1↑, 1,   NRF2↓, 1,   ROS↑, 9,   TrxR1↑, 1,   VitC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 3,   MPT↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 3,   Apoptosis↑, 13,   BAX↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 3,   Casp↑, 2,   Casp3↑, 3,   Casp9↑, 2,   Cyt‑c↑, 2,   Fas↑, 1,   Ferroptosis↑, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   p27/CDKN1B↑, 1,   PPP2R1A↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   UPR↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   p‑P53↓, 1,   cl‑PARP↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 2,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 2,   CSCs↓, 6,   EMT↓, 3,   FOXO3↓, 1,   LRP6↓, 2,   p‑LRP6↓, 1,   mTOR↓, 1,   PI3K↓, 3,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 3,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 3,   TGF-β↓, 2,   TIMP1↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 10,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 5,   p‑NF-kB↑, 1,   TLR1↑, 1,   TLR4↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   Dose↝, 3,   eff↓, 2,   eff↑, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   EGFR↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 3,   Risk⇅, 1,   toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 113

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   Learn↑, 1,   Stroke↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Copper↓, 1,   GPx↑, 1,   Iron↓, 2,   MDA↓, 1,   ROS↓, 7,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTL↓, 1,   IronCh↑, 1,   TfR1/CD71↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↑, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Casp3↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   NOTCH↓, 1,   PI3K↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

MMP2↑, 1,   PKA↑, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CLDN5↓, 1,   Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   OCLN↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 5,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 9,   BDNF↑, 4,   NGF↑, 1,   PSD95↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   Aβ↑, 1,   BACE/β-secretase↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 6,   Dose↑, 1,   Dose↝, 7,   eff∅, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 3,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↓, 1,   cognitive↑, 10,   cognitive∅, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 10,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 68

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page