| 7593- | I3C, | Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells |
| - | Review, | Pca, | NA |
| 7594- | I3C, | Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers |
| - | Human, | Nor, | NA |
| 1277- | I3C, | GEN, | Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein |
| - | in-vitro, | PC, | PANC1 |
| 1278- | I3C, | Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin |
| - | in-vivo, | Pca, | DU145 |
| 7385- | IBC, | Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction |
| - | vitro+vivo, | Lung, | A549 | - | in-vitro, | BC, | 4T1 |
| 7801- | IBC, | Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter |
| - | in-vitro, | CRC, | HT-29 |
| 7770- | IBC, | Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction |
| - | in-vitro, | Lung, | NA | - | vitro+vivo, | BC, | 4T1 |
| 7802- | IBC, | Isobavachalcone disrupts mitochondrial respiration and induces cytotoxicity through ROS accumulation and Akt suppression |
| - | in-vitro, | NA, | HepG2 |
| 7803- | IBC, | Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response |
| - | in-vivo, | Nor, | NA | - | in-vitro, | NA, | HepG2 |
| 7804- | IBC, | Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms |
| - | Review, | Nor, | NA |
| 7805- | IBC, | The enhanced hepatotoxicity of isobavachalcone in depigmented zebrafish due to calcium signaling dysregulation and lipid metabolism disorder |
| - | in-vivo, | Nor, | NA |
| 7806- | IBC, | Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway |
| - | in-vitro, | PC, | NA |
| 7807- | IBC, | Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway |
| - | in-vitro, | Liver, | HepG2 | - | in-vitro, | Liver, | Hep3B | - | in-vitro, | Nor, | L02 |
| 7808- | IBC, | Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells |
| - | in-vitro, | Tong, | Tca8113 |
| 7809- | IBC, | Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways |
| - | in-vitro, | GC, | MGC803 |
| 7818- | IBC, | Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma |
| - | in-vitro, | neuroblastoma, | NA |
| 7767- | IBC, | Isobavachalcone exerts anti-gastric cancer effects by targeting dihydroorotate dehydrogenase to induce ROS release and activating the STING pathway |
| - | vitro+vivo, | GC, | NA |
| 7768- | IBC, | Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells |
| - | in-vitro, | NA, | PC3 |
| 7769- | IBC, | Potential Determinants for Metabolic Fates and Inhibitory Effects of Isobavachalcone Involving in Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Efflux Transporters |
| - | in-vivo, | NA, | NA |
| 7776- | IBC, | Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation |
| - | vitro+vivo, | PC, | Panc02 |
| 7775- | IBC, | Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 7774- | IBC, | Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | CRC, | SW480 |
| 7773- | IBC, | Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells |
| - | in-vitro, | Var, | NA |
| 7772- | IBC, | Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation |
| - | vitro+vivo, | AML, | NA |
| 7771- | IBC, | Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME |
| - | vitro+vivo, | Thyroid, | CAL-62 |
| 7709- | IBC, | Isobavachalcone ameliorates cognitive deficits, and Aβ and tau pathologies in triple-transgenic mice with Alzheimer's disease |
| - | in-vivo, | AD, | NA |
| 7710- | IBC, | Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice |
| - | vitro+vivo, | AD, | NA |
| 7711- | IBC, | Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo |
| - | vitro+vivo, | BC, | NA |
| 7578- | IMA, | Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia |
| - | Trial, | CML, | NA |
| 7579- | IMA, | One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial |
| - | Trial, | GC, | NA |
| 7613- | InA, | Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii |
| - | Study, | Nor, | NA |
| 7614- | InA, | Inoscavin A, a new free radical scavenger from the mushroom Inonotus xeranticus |
| - | Study, | Nor, | NA |
| 33- | InA, | Inoscavin A, a pyrone compound isolated from a Sanghuangporus vaninii extract, inhibits colon cancer cell growth and induces cell apoptosis via the hedgehog signaling pathway |
| - | vitro+vivo, | Colon, | NA |
| 7628- | Ins, | Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line |
| - | in-vitro, | Pca, | DU145 |
| 7617- | Ins, | miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting |
| - | in-vitro, | BC, | NA |
| 7616- | Ins, | A phase I study of myo-inositol for lung cancer chemoprevention |
| - | Trial, | Nor, | NA |
| 7615- | Ins, | A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia |
| 7630- | Ins, | Modulation of both Insulin Resistance and Cancer Growth by Inositol |
| - | Review, | Var, | NA | - | Review, | Diabetic, | NA |
| 7629- | Ins, | Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol |
| - | in-vivo, | Lung, | NA |
| 7648- | Ins, | Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inositol |
| - | in-vivo, | Liver, | NA |
| 7647- | Ins, | Chemoprevention of pulmonary carcinogenesis by myo-inositol |
| - | Review, | Lung, | NA |
| 7637- | Ins, | Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes |
| - | vitro+vivo, | BC, | 4T1 |
| 7635- | Ins, | The Role of Inositols in Endocrine and Neuroendocrine Tumors |
| - | Review, | Thyroid, | NA |
| 7634- | Ins, | Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors |
| - | Trial, | Nor, | NA |
| 7636- | Ins, | Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models |
| 7638- | Ins, | d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI) |
| - | Review, | Nor, | NA |
| 7639- | Ins, | Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells |
| - | in-vitro, | Nor, | MCF10 |
| 7641- | Ins, | Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis |
| - | Review, | CRC, | NA |
| 7643- | Ins, | IP6, | Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical stud |
| - | Trial, | BC, | NA |
| 7631- | Ins, | IP6, | Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate |
| - | Review, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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