Database Query Results : , , RARα

RARα, RARα (NR1B1): Click to Expand ⟱
Source:
Type:
The retinoic acid receptors (RARs) are members of the nuclear receptor superfamily and function as ligand-activated transcription factors.
Three main isoforms have been characterized:
• RARα (NR1B1)
• RARβ (NR1B2)
• RARγ (NR1B3)
They bind retinoic acid (the active metabolite of vitamin A) and regulate gene expression programs involved in cell differentiation, proliferation, and apoptosis.

RARα is often found to be ubiquitously expressed at baseline in many tissues.
In solid tumors, aberrant RARα expression has been observed, but its prognostic role can be variable—sometimes correlating with a more aggressive phenotype if the downstream signaling is disrupted.
Scientific Papers found: Click to Expand⟱
1102- BBR,    Berberine suppressed epithelial mesenchymal transition through cross-talk regulation of PI3K/AKT and RARα/RARβ in melanoma cells
- in-vitro, Melanoma, B16-BL6
TumCMig↓, TumCI↓, EMT↓, p‑PI3K↓, p‑Akt↓, RARα↓, RARβ↑, RARγ↑, E-cadherin↑, N-cadherin↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

RARα↓, 1,   RARβ↑, 1,   RARγ↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑PI3K↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RARα, RARα (NR1B1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1001  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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