Database Query Results : , , GREM1

GREM1, Gremlin1: Click to Expand ⟱
Source:
Type:
GREM1 encodes Gremlin1, a secreted glycoprotein that acts primarily as an antagonist of bone morphogenetic proteins (BMPs). By modulating BMP signaling, Gremlin1 plays an important role in embryonic development, tissue differentiation, and organogenesis. In cancer, dysregulation of GREM1 can impact cell proliferation, differentiation, and migration, contributing to tumor progression.

Its aberrant overexpression in various cancers correlates with more aggressive tumor features and poorer patient outcomes, positioning it as a promising prognostic biomarker.
Scientific Papers found: Click to Expand⟱
1109- DHA,    DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells
- in-vitro, BC, NA
GREM1↓, TumCMig↓, p‑ERK↓, EMT↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   p‑ERK↓, 1,   GREM1↓, 1,  

Migration ⓘ

TumCMig↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GREM1, Gremlin1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1007  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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