Database Query Results : , , EMMPRIN

EMMPRIN, Extracellular Matrix Metalloproteinase Inducer: Click to Expand ⟱
Source:
Type:
EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as CD147 or basigin EMMPRIN is a transmembrane glycoprotein that facilitates intercellular communication.
It is best known for its role in upregulating matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix (ECM). This degradation is a key step in tumor invasion and metastasis.

EMMPRIN is overexpressed in a wide range of cancers, including breast, head and neck, lung, liver, and colorectal cancers, among others.
Increased EMMPRIN expression is often observed in more aggressive tumor types and is correlated with enhanced invasive capabilities.
High EMMPRIN levels are detected not only in tumor cells but also in the surrounding stromal cells, supporting a pro-tumorigenic microenvironment.
Scientific Papers found: Click to Expand⟱
1148- ART/DHA,    Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
- in-vitro, AML, THP1
MMP9↓, EMMPRIN↓, p‑PKCδ↓, p‑JNK↓, p‑p38↓, p‑ERK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑JNK↓, 1,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Migration ⓘ

EMMPRIN↓, 1,   MMP9↓, 1,   p‑PKCδ↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EMMPRIN, Extracellular Matrix Metalloproteinase Inducer
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1020  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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