Database Query Results : , , PGD2

PGD2, prostaglandin D2: Click to Expand ⟱

Source:

Type:

PGD2 is one of several prostaglandins produced through the cyclooxygenase (COX) pathway, primarily via the action of hematopoietic and lipocalin-type prostaglandin D synthases (HPGDS and L-PGDS, respectively). It plays roles in inflammation, immune modulation, and cellular signals that can influence tumor development and progression.

PGD2 is a prostaglandin with complex roles in cancer biology, mediating processes such as inflammation, immune modulation, and cellular differentiation. In various cancers—including breast, prostate, colorectal, lung, and ovarian cancers—alterations in PGD2 production or PGD2 synthase expression have been reported. Often, higher PGD2 signaling correlates with more favorable outcomes, likely through mechanisms involving anti-inflammatory, pro-differentiation, and pro-apoptotic effects. However, the effects of PGD2 can be context-dependent.

Scientific Papers found: Click to Expand⟱

1162-

PI,

Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response

in-vitro,

NA,

Rabbit platelets and murine macrophage RAW264.7 cells were treated with piperine

*cPLA2↓, TXA2↓, COX2↓, PGE2↓, PGD2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Angiogenesis & Vasculature ⓘ

TXA2↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, PGD2↓, 1, PGE2↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

cPLA2↓, 1,
Total Targets: 1

Scientific Paper Hit Count for: PGD2, prostaglandin D2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells