Database Query Results : , , ACC1

ACC1, acetyl‐CoA carboxylase 1: Click to Expand ⟱
Source:
Type:
ACC1 (encoded by the ACACA gene) is a key enzyme in de novo lipogenesis. It catalyzes the carboxylation of acetyl‐CoA to malonyl‐CoA, a critical step in fatty acid synthesis. Because lipids are essential for membrane synthesis and energy storage, ACC1 plays a critical role in cell growth and metabolism.

ACC1 plays a central role in fatty acid synthesis, and its dysregulation is closely linked to cancer metabolism. In many cancer types, overexpression of ACC1 is associated with:
-Enhanced lipid production to support rapid proliferation,
-Aggressive tumor behavior and potentially poorer prognosis,
-Promotion of a vulnerable metabolic state that could be targeted therapeutically.

ACC1’s expression level may serve as a prognostic marker. Studies have suggested that patients with tumors showing high ACC1 expression may have decreased overall survival or may progress more rapidly.
Scientific Papers found: Click to Expand⟱
1172- Ash,    Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
FASN↓, ACLY↓, ACC1↓, CPT1A↓, SREBP1↓,
2404- SFN,    Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
ACC1↓, FASN↓, CPT1A↓, β-oxidation↓, SREBP1?, HK2↓, PKM2↓, LDHA↓, Glycolysis↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ACC1↓, 2,   ACLY↓, 1,   CPT1A↓, 2,   FASN↓, 2,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   SREBP1?, 1,   SREBP1↓, 1,   β-oxidation↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ACC1, acetyl‐CoA carboxylase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1033  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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