Database Query Results : , , SDC1

SDC1, Syndecan-1 (SDC-1): Click to Expand ⟱

Source:

Type:

Syndecan-1 (SDC-1), a transmembrane heparan sulfate proteoglycan, supports the integrity of the epithelial compartment.
Syndecan-1 is a transmembrane heparan sulfate proteoglycan that functions as a coreceptor in cell–matrix and cell–cell interactions. It plays a key role in modulating signaling pathways through its extracellular domain, which interacts with growth factors, cytokines, and components of the extracellular matrix. Through these interactions, Syndecan-1 influences critical cellular processes such as adhesion, proliferation, migration, and differentiation.

The expression of Syndecan-1 is often deregulated. However, its expression can be either upregulated or downregulated depending on the tumor type and its stage of progression. For example, high levels of Syndecan-1 are observed in multiple myeloma, while in other cancers, such as certain carcinomas, loss or redistribution from the cell membrane to the cytoplasm is linked with tumor progression.

Scientific Papers found: Click to Expand⟱

1184-

DHA,

Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer

in-vitro,

Pca,

PC3

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

SDC1↑, p‑PCK1↓, Akt↓, BAD↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

p‑PCK1↓, 1,

Cell Death ⓘ

Akt↓, 1, BAD↓, 1,

Migration ⓘ

SDC1↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SDC1, Syndecan-1 (SDC-1)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells