Database Query Results : , , TLR1

TLR1, Toll-Like Receptor 1: Click to Expand ⟱
Source:
Type:
TLR1 is one of the Toll-like receptors (TLRs), a family of pattern recognition receptors that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).

TLR1 expression is not confined solely to immune cells; its expression has also been detected in various tumor cells as well as in the surrounding stroma. Aberrant expression or activation of TLR1 in the tumor microenvironment can influence both innate and adaptive immune responses within tumors. This modulation can have complex effects on tumor progression.

Due to its dual role, TLR1 holds potential as both a prognostic biomarker and a therapeutic target.
Scientific Papers found: Click to Expand⟱
4641- HT,    Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,
1195- SM,    Salvia miltiorrhiza polysaccharide activates T Lymphocytes of cancer patients through activation of TLRs mediated -MAPK and -NF-κB signaling pathways
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2 - in-vitro, CRC, HCT116
T-Cell↑, TumCP∅, IL4↑, IL6↑, IFN-γ↑, TLR4↑, TLR1↑, TLR2↑, p‑JNK↑, p‑ERK↑, IKKα↑,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   NRF2↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,   p‑JNK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,  

Migration ⓘ

TumCP∅, 1,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↑, 1,   IKKα↑, 1,   IL4↑, 1,   IL6↑, 1,   T-Cell↑, 1,   TLR1↑, 2,   TLR2↑, 1,   TLR4↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TLR1↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: TLR1, Toll-Like Receptor 1
1 HydroxyTyrosol
1 Salvia miltiorrhiza
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1041  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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