Database Query Results : , , Brk/PTK6

Brk/PTK6, Breast Tumor Kinase/Protein Tyrosine Kinase 6: Click to Expand ⟱
Source:
Type:
Breast Tumor Kinase (BrK), also known as Protein Tyrosine Kinase 6 (PTK6).
BrK is involved in intracellular signaling, influencing pathways related to cell proliferation, migration, and differentiation.
– In normal tissues, its expression is often limited; however, aberrant expression in tumors may contribute to oncogenic processes, including enhanced cell survival and metastatic potential.
– The kinase modulates key signaling cascades such as PI3K/AKT and MAPK that drive tumor progression.

BrK is most widely studied in breast cancer where it is frequently overexpressed, especially in a subset of tumors that do not express classical receptors (e.g., triple-negative breast cancers) as well as in some hormone receptor–positive cases.
High BrK expression has been linked in several studies to enhanced tumor progression, increased metastasis, and a poorer overall survival.
Scientific Papers found: Click to Expand⟱
1203- MSM,    Methylsulfonylmethane Suppresses Breast Cancer Growth by Down-Regulating STAT3 and STAT5b Pathways
- vitro+vivo, BC, MDA-MB-231
tumCV↓, STAT3↓, STAT5↓, IGF-1↓, Hif1a↓, VEGF↓, Brk/PTK6↓, IGF-1R↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGF-1R↓, 1,   STAT3↓, 1,   STAT5↓, 1,  

Migration ⓘ

Brk/PTK6↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Brk/PTK6, Breast Tumor Kinase/Protein Tyrosine Kinase 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1045  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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