Database Query Results : , , HSD17B4

HSD17B4, hydroxysteroid 17-beta dehydrogenase 4: Click to Expand ⟱
Source:
Type:
HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) is a multifunctional enzyme predominantly involved in peroxisomal β‑oxidation of fatty acids and steroid metabolism. Its dysregulation has attracted attention in various cancers.
Breast Cancer
• Expression:
– Some studies have observed altered HSD17B4 expression in breast cancer tissues compared to normal tissues. In certain cohorts, overexpression has been noted, which may affect local steroid metabolism and estrogen synthesis.
• Prognosis:
– Overexpression in some reports has been linked to endocrine resistance and a more aggressive phenotype, suggesting a potential role as a marker of unfavorable prognosis.

Hepatocellular Carcinoma (HCC)
• Expression:
– In liver cancers, HSD17B4 expression may be aberrant. Some studies have reported increased expression compared to non-tumor liver tissues, potentially reflecting metabolic reprogramming in cancer cells.
• Prognosis:
– Elevated HSD17B4 expression in HCC has been associated in certain reports with poor survival outcomes, suggesting its involvement in tumor metabolism and progression.
Scientific Papers found: Click to Expand⟱
1213- VitK2,    Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
- in-vitro, HCC, HepG2
HSD17B4↓, Akt↓, MEK↓, ERK↓, STAT3↓, TumCP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↓, 1,  

Core Metabolism/Glycolysis ⓘ

HSD17B4↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSD17B4, hydroxysteroid 17-beta dehydrogenase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1048  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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