Database Query Results : , , SOD1

SOD1, superoxide dismutase 1: Click to Expand ⟱
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Type:
SOD1 (superoxide dismutase 1) is a key antioxidant enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide.

In several cancers including breast, lung, HCC, and others, alterations in SOD1 expression have been observed, reflecting its role in managing oxidative stress.
• Elevated SOD1 levels are sometimes associated with aggressive tumor behavior, therapy resistance, or decreased apoptosis due to enhanced ROS detoxification.
• Conversely, the protective role of antioxidants can also mitigate oxidative mutation loads, leading to context-dependent and occasionally favorable outcomes.

In non-small cell lung cancer (NSCLC), increased SOD1 levels have been reported in some cohorts, potentially as a mechanism to cope with high reactive oxygen species (ROS) levels.
Scientific Papers found: Click to Expand⟱
265- ALA,    Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↓, SOD↓, GSTP1/GSTπ↓, NRF2↓, p62↓, p62↑, SOD↑, p‑mTOR↑, Beclin-1↓, ROS↑, SOD1↑,
1235- ALA,  Cisplatin,    α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- in-vitro, Nor, HEI-OC1 - ex-vivo, NA, NA
ROS↑, HO-1↓, *toxicity↓, chemoP↑, *ROS↓, *HO-1↑, *SOD1↑, *NRF2↑,
2612- Ba,  MF,    The effect of a static magnetic field and baicalin or baicalein interactions on amelanotic melanoma cell cultures (C32)
- in-vitro, Melanoma, NA
SOD1↑, SOD2↑, GPx1↑, Dose?, eff↝, SOD1↓, SOD2↓, GPx1↓,
2654- CUR,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, Catalase↓, SOD1↓, GLO-I↓, NADPH↓, TumCCA↑, Apoptosis↑, Akt↓, ER Stress↑, JNK↑, STAT3↓, BioAv↑,
4990- Dipy,    Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management
- in-vivo, Nor, NA
*Ferroptosis↓, *HO-1↓, SOD1↑,
5012- DSF,  Cu,    Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
ROS↑, ALDH↓, TumCP↓, CSCs↓, angioG↓, TumMeta↓, DNAdam↑, Proteasome↓, SOD1↓, GSR↓, ox-GSSG↑, GSH/GSSG↓, MMP↓, Akt↓, cycD1/CCND1↓, NF-kB↓, CSCs↓, MAPK↓, angioG↓, DrugR↓, EMT↓, Vim↓, BioAv↑, eff↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
3212- EGCG,    EGCG maintained Nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells
- in-vitro, Lung, A549 - in-vivo, Lung, NCIH23
NRF2⇅, eff↑, SOD1↑, SOD1↓, MMP2⇅, MMP9⇅,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
3457- MF,    Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis
- Review, Var, NA
Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
3567- MFrot,  MF,    The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review
- Review, Stroke, NA
*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
1942- PL,    Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines
- in-vitro, BC, MCF-7
ROS↑, SOD1↑, Trx1↓, Catalase↓, PrxII↓, ROS↑, GADD45A↑, P21↑, DNAdam↑, TumCCA↑,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
4909- Sal,    Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
- vitro+vivo, CRC, NA
AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,
3296- SIL,    Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
- in-vitro, Oral, Ca9-22 - in-vivo, Oral, YD10B
TumCP↓, TumCCA↑, ROS↑, SOD1↓, SOD2↓, *JNK↑, toxicity?, TumCMig↓, TumCI↓, N-cadherin↓, Vim↓, E-cadherin↑, EMT↓, P53↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, SOD↓,
1344- SK,    Novel multiple apoptotic mechanism of shikonin in human glioma cells
- in-vitro, GBM, U87MG - in-vitro, GBM, Hs683 - in-vitro, GBM, M059K
ROS↑, GSH↓, MMP↓, P53↑, cl‑PARP↑, Catalase↓, SOD1↑, Bcl-2↓, BAX↑, eff↓,
3420- TQ,    Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway
- in-vitro, Nor, HUVECs - in-vitro, NA, NA
*NF-kB↓, *NLRP3↓, *angioG↑, *MMP9↑, *VEGF↑, *OS↑, *Pyro?, *ROS↓, *Apoptosis↓, *SIRT1↑, *SOD1↑, *HO-1↑, *eNOS↑, *ASC?, *Casp1↓, *IL1β↓, *IL18↓,
2089- TQ,    Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes
- in-vitro, Nor, SH-SY5Y
*neuroP↑, *ROS↓, *SOD1↑, *Catalase↑,
2087- TQ,    Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
- in-vivo, Nor, NA
*LDL↓, *SOD1↑, *Catalase↑, *GPx↑, *antiOx↑,
5024- TQ,    Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?
- Review, Covid, NA
*NRF2↑, *NF-kB↓, *Inflam↓, *ROS↓, *HO-1↑, antiOx↑, GSH↑, GSTs↑, GSR↑, SOD1↑, Catalase↑, GPx↑, p62↓, Beclin-1↑, Sepsis↓, cardioP↑, hepatoP↑, neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

DrugR↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 3,   Catalase↑, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   GPx↑, 1,   GPx1↓, 1,   GPx1↑, 1,   GSH↓, 4,   GSH↑, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 1,   ox-GSSG↑, 1,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   NRF2⇅, 1,   PrxII↓, 1,   ROS↓, 1,   ROS↑, 11,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 2,   SOD1↓, 6,   SOD1↑, 8,   SOD2↓, 2,   SOD2↑, 2,   Trx1↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 3,   mtDam↑, 1,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   CYP3A4↓, 1,   GLO-I↓, 1,   GlutMet↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   NADPH↓, 1,  

Cell Death ⓘ

Akt↓, 4,   Apoptosis↑, 4,   Bak↑, 1,   BAX↑, 4,   Bcl-2↓, 4,   Bcl-xL↓, 1,   BIM↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Cyt‑c↑, 2,   DR4↑, 1,   Fas↑, 1,   HGF/c-Met↓, 1,   JNK↑, 2,   MAPK↓, 2,   MAPK↑, 1,   MDM2↓, 1,   p38↑, 1,   Proteasome↓, 1,   survivin↓, 2,   Telomerase↓, 2,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,   HSPs↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   Beclin-1↑, 1,   p62↓, 2,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   DNMTs↓, 1,   GADD45A↑, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   cFos↓, 1,   cMET↓, 1,   CSCs↓, 2,   CSCs↑, 1,   EMT↓, 4,   ERK↓, 2,   p‑FOXO3↓, 1,   HDAC↓, 1,   mTOR↓, 1,   p‑mTOR↑, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PTEN↑, 1,   SOX2↓, 1,   STAT3↓, 2,   TOP2↓, 1,   TumCG↓, 2,  

Migration ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 1,   MMP2⇅, 1,   MMP9↓, 2,   MMP9⇅, 1,   MMPs↓, 2,   N-cadherin↓, 2,   Slug↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 1,   Vim↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 2,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   IL6↓, 1,   IL8↓, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 3,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   ChemoSen↑, 6,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 1,   eff↓, 2,   eff↑, 4,   eff↝, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 2,   HER2/EBBR2↓, 1,   p‑HER2/EBBR2↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 2,   hepatoP↑, 1,   neuroP↑, 1,   Risk↓, 1,   toxicity?, 1,   toxicity↓, 1,   TumW↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 183

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 6,   Ferroptosis↓, 1,   GPx↑, 2,   GPx1↑, 5,   GPx4↑, 4,   GSH↑, 1,   GSR↑, 1,   HO-1↓, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 6,   OXPHOS↓, 1,   RNS↓, 1,   ROS↓, 10,   SOD↑, 2,   SOD1↑, 12,   SOD2↑, 5,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mitResp↓, 1,   mtDam↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   Glycolysis↑, 1,   HK2↑, 1,   LDL↓, 1,   PFKL↑, 1,   PFKM↑, 1,   PKM2↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp1↓, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   JNK↑, 1,   Pyro?, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↝, 2,   tumCV↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,   IGF-1R↓, 1,  

Migration ⓘ

AP-1↓, 1,   APP↓, 1,   MMP2↓, 1,   MMP9↑, 1,   TumCMig↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   eNOS↑, 1,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↑, 1,  

Immune & Inflammatory Signaling ⓘ

ASC?, 1,   COX2↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL1β↑, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 4,   JAK↓, 1,   NF-kB↓, 3,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↓, 1,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   Dose↝, 4,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

BP∅, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 2,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,   OS↑, 1,   toxicity?, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 93

Scientific Paper Hit Count for: SOD1, superoxide dismutase 1
6 Magnetic Fields
4 Thymoquinone
2 Alpha-Lipoic-Acid
2 EGCG (Epigallocatechin Gallate)
2 Piperlongumine
1 Cisplatin
1 Baicalein
1 Curcumin
1 Dipyridamole
1 Disulfiram
1 Copper and Cu NanoParticlex
1 Hydrogen Gas
1 Magnetic Field Rotating
1 Phenethyl isothiocyanate
1 salinomycin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1052  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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