Database Query Results : , , CCL20

CCL20, Chemokine [C-C motif] ligand 20: Click to Expand ⟱

Source:

Type:

CCL20 (Chemokine [C-C motif] ligand 20), also known as MIP-3α, plays a role in immune cell recruitment and inflammation.

Upregulation in Tumors:
– Many studies have noted elevated levels of CCL20 in tumor tissues compared to adjacent normal tissues in various cancers such as colorectal, hepatocellular, breast, and pancreatic cancers.
– Increased CCL20 expression is often associated with an inflammatory tumor microenvironment that promotes tumor cell migration and invasion.

Elevated CCL20 levels have been correlated with enhanced tumor invasiveness and metastasis in several cancer types, likely driven by its ability to modulate the local immune response and promote a pro-tumorigenic microenvironment.

Scientific Papers found: Click to Expand⟱

1250-

Bif,

Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

in-vitro,

SCC,

TumCG↓, Apoptosis↑, CCL20↑, IL12↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1,

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,

Immune & Inflammatory Signaling ⓘ

CCL20↑, 1, IL12↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CCL20, Chemokine [C-C motif] ligand 20

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells