Database Query Results : , , FBI-1

FBI-1, FBI‑1 (Pokemon/ZBTB7A): Click to Expand ⟱
Source:
Type:
FBI-1 (also known as Pokemon, encoded by the ZBTB7A gene)
FBI‑1 is a transcriptional regulator that can act as either a repressor or an activator of target genes.
• It is involved in processes such as cell cycle progression, apoptosis, and metabolism.

Overexpression of FBI‑1 in tumors such as breast, colorectal, lung, and ovarian cancer has been associated in many reports with more aggressive tumor behavior and potentially poorer prognostic outcomes.
Scientific Papers found: Click to Expand⟱
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
2989- RES,    Resveratrol Represses Pokemon Expression in Human Glioma Cells
- in-vitro, GBM, NA
FBI-1↓, Sp1/3/4↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

FBI-1↓, 2,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TumCP↓, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FBI-1, FBI‑1 (Pokemon/ZBTB7A)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1058  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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