Database Query Results : , , compIII

compIII, Mitochondrial complex III: Click to Expand ⟱
Source:
Type:
Complex III is part of the mitochondrial respiratory chain. It plays a key role in oxidative phosphorylation by transferring electrons from ubiquinol (coenzyme Q) to cytochrome c.
• The complex is made up of multiple subunits. In humans, some of the key proteins include:
-UQCRC1 (ubiquinol-cytochrome c reductase core protein I)
-UQCRC2 (core protein II)
-UQCRFS1 (the Rieske iron-sulfur protein)
-UQCRB (cytochrome b)

Complex III is a significant source of reactive oxygen species (ROS) when electron transport is inefficient. Increased ROS can promote DNA damage and genomic instability, factors known to drive cancer progression.
Expression levels of Complex III subunits, particularly UQCRFS1 and UQCRC1, have been evaluated as biomarkers. High expression may suggest a more aggressive tumor phenotype, thus linking mitochondrial respiratory chain activity with clinical outcomes.
Scientific Papers found: Click to Expand⟱
1355- Ash,    Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, HMEC
eff↑, mt-ROS↑, mitResp↓, OXPHOS↓, compIII↑, BAX↑, Bak↑, other↓, ATP∅, *ROS∅,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   compI↓, 1,   GPx↓, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   OXPHOS↓, 1,   ROS↑, 1,   mt-ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ATP∅, 1,   compIII↓, 1,   compIII↑, 1,   mitResp↓, 1,   MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 2,   selectivity↑, 2,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS∅, 2,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 2

Scientific Paper Hit Count for: compIII, Mitochondrial complex III
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1070  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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