Database Query Results : , , p85S6K

p85S6K, isoform of S6 kinase: Click to Expand ⟱
Source:
Type:
S6 kinases are a family of serine/threonine kinases that play an important role in mediating protein synthesis, cell growth, and metabolism.
They are downstream effectors of the mTOR pathway, a central regulator of cellular metabolism that integrates signals from nutrients, growth factors, and energy status.
• p85 S6K Specifics:
The p85 S6K isoform (sometimes noted in contrast to other S6K isoforms such as p70 S6K) has been identified in certain cell types and under specific conditions.
While the p70 isoform is more widely studied, p85 S6K has been associated with distinct regulatory roles, potentially linking mTOR signaling with other cellular processes.

Overactivation of mTOR and its downstream targets (including S6K) frequently correlates with enhanced cell growth, survival, and metabolic reprogramming in tumor cells.
Increased S6K activity (and by extension, higher levels of p85 S6K in relevant contexts) has sometimes been correlated with poor prognosis, including lower overall survival and increased tumor aggressiveness.

The p85 S6K isoform, as part of the broader mTOR/S6K axis, plays a role in regulating protein synthesis and cell proliferation—a link that is particularly significant in cancer. Its expression and activation status have been associated with tumor aggressiveness and poor prognosis in certain cancers.
Scientific Papers found: Click to Expand⟱
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   p70S6↓, 1,   TSC2↑, 1,  

Protein Folding & ER Stress ⓘ

HSF1↓, 1,   HSP70/HSPA5↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   p85S6K↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: p85S6K, isoform of S6 kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1071  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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