Database Query Results : , , Alix/AIP‑1

Alix/AIP‑1, Alix (ALG‑2–interacting protein X): Click to Expand ⟱
Source:
Type:
Alix (ALG‑2–interacting protein X), also known as AIP‑1, is a multifunctional protein that interacts with actin and other components of the cytoskeleton.

– Altered expression or localization of Alix has been observed in various cancers, including breast, prostate, and colorectal cancers.
– Alix may contribute to tumor growth by affecting apoptosis and cell survival. In some contexts, it is suggested that Alix can modulate apoptotic signaling pathways.
– Studies have reported that Alix expression may be upregulated in certain tumor types, with changes in subcellular localization (e.g., increased cytoplasmic or membranous expression) linked to aggressive behavior.
– In some cancers, altered Alix levels have been associated with enhanced invasive and metastatic potential.
Scientific Papers found: Click to Expand⟱
1359- Ash,    Withaferin A Induces ROS-Mediated Paraptosis in Human Breast Cancer Cell-Lines MCF-7 and MDA-MB-231
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
MMP↓, Alix/AIP‑1↓, ROS↑, Paraptosis↑, ER Stress↝,
2863- HNK,    Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells
- in-vitro, Liver, Hep3B
ER Stress↑, Ca+2↑, mtDam↑, PTEN↑, PARK2↑, Alix/AIP‑1↓, ROS↑, mt-ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PARK2↑, 1,   ROS↑, 2,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   mtDam↑, 1,  

Cell Death ⓘ

Paraptosis↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   ER Stress↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,  

Migration ⓘ

Alix/AIP‑1↓, 2,   Ca+2↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Alix/AIP‑1, Alix (ALG‑2–interacting protein X)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1079  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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