Database Query Results : , , Set9

Set9, SETD7 (SET domain containing lysine methyltransferase 7): Click to Expand ⟱
Source:
Type:
Set9, also known as SETD7 (SET domain containing lysine methyltransferase 7), is an enzyme that mediates the methylation of lysine residues on both histone and non-histone proteins.

SETD7 (Set9) is a lysine methyltransferase with complex roles in cancer, affecting both histone and non-histone proteins. Its expression can influence key pathways related to cell cycle control, apoptosis, and inflammation. The prognostic implications of SETD7 expression in cancers are nuanced—while in some instances it supports tumor-suppressive mechanisms (e.g., via p53 activation), in others it may promote tumor progression through alternative signaling pathways, such as those mediated by NF-κB.
Scientific Papers found: Click to Expand⟱
1400- BBR,    Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells
- in-vitro, Melanoma, U266
ROS↑, TumCCA↑, Apoptosis↑, miR-21↓, Bcl-2↓, NF-kB↓, Set9↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Set9↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Set9, SETD7 (SET domain containing lysine methyltransferase 7)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1082  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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