Database Query Results : , , GlutaM

GlutaM, Glutaminolysis: Click to Expand ⟱
Source:
Type:
Glutaminolysis is the metabolic process through which glutamine, a non-essential amino acid, is catabolized to support cellular energy and biosynthesis. In many cancer cells, glutaminolysis is upregulated to meet the high demands for energy (ATP), biosynthetic precursors, and maintenance of redox balance.
Key Steps and Abbreviations in Glutaminolysis.
Glutamine (Gln): uptake of glutamine from the extracellular environment.
Glutaminase (GLS):Converts glutamine into glutamate by deamination. GLS overexpressed in cancers.
Glutamate (Glu): further converted into α-ketoglutarate (α-KG).
Glutamate Dehydrogenase (GDH): Catalyzes the conversion of glutamate to α-KG, feeding the tricarboxylic acid cycle (TCA, also known as Krebs cycle).
α-Ketoglutarate (α-KG):α-KG is a key intermediate in the TCA cycle.
Additional Players:
c-Myc: A transcription factor frequently overexpressed in cancer that upregulates genes involved in glutamine uptake and metabolism, including GLS.
SLC1A5 (ASCT2): A glutamine transporter that is often upregulated in cancer to facilitate increased glutamine uptake.

In many cancers there is an upregulation of key glutaminolysis components:GLS, SLC1A5, c-Myc. Many studies have found that overexpression of glutaminolysis-related enzymes (especially GLS) correlates with aggressive tumor behavior and poor patient outcomes.
Scientific Papers found: Click to Expand⟱
2542- M-Blu,    In Vitro Methylene Blue and Carboplatin Combination Triggers Ovarian Cancer Cells Death
- in-vitro, Ovarian, OV1369 - in-vitro, Ovarian, OV1946 - in-vitro, Nor, ARPE-19
BioAv↝, TumCP↓, GlutaM↓, Warburg↓, OCR↑, Glycolysis↓, ATP↓, BioAv↝, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

GlutaM↓, 1,   Glycolysis↓, 1,   Warburg↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 2,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GlutaM, Glutaminolysis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1083  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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