Database Query Results : , , MGMT

MGMT, O^6^-methylguanine-DNA methyltransferase: Click to Expand ⟱
Source:
Type:
MGMT (O^6^-methylguanine-DNA methyltransferase) is a DNA repair enzyme that plays a crucial role in protecting the genome from alkylating damage. Key points include:
-MGMT repairs DNA lesions by removing alkyl groups from the O^6^-position of guanine, thereby preventing mutations.
-It is a “suicide enzyme,” meaning that it is inactivated after repairing one lesion.
-By counteracting the cytotoxic effects of alkylating agents, MGMT is a critical determinant of cell survival following exposure to such chemotherapeutic agents.

In several cancers, the MGMT promoter is hypermethylated. This epigenetic modification suppresses MGMT expression and has several implications:
-Reduced MGMT levels lead to an accumulation of DNA damage.
-Increased mutation rates can contribute to cancer initiation and progression.

MGMT expression levels in tumors have a significant impact on the response to alkylating agents (e.g., temozolomide in glioblastoma).
-High MGMT Expression: Can confer resistance to these drugs by effectively repairing the induced DNA damage.
-Low MGMT Expression: Often observed in tumors with MGMT promoter hypermethylation, making the cancer cells more susceptible to chemotherapeutic agents.

Improved Prognosis with Low MGMT Expression in Specific Contexts (high MGMT activity can allow tumor cells to recover from DNA damage).
Scientific Papers found: Click to Expand⟱
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
3371- QC,    Quercetin induces MGMT+ glioblastoma cells apoptosis via dual inhibition of Wnt3a/β-Catenin and Akt/NF-κB signaling pathways
- in-vitro, GBM, T98G
TIMP2↑, TumCG↓, TumCMig↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, Bax:Bcl2↑, cl‑Casp9↑, cl‑Casp3↑, DNAdam↑, γH2AX↑, MGMT↓, cl‑PARP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

frataxin↑, 1,   NRF2↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Mcl-1↓, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   MGMT↓, 3,   P53↑, 2,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   TumCG↓, 1,  

Migration ⓘ

FAK↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   Snail↓, 1,   TIMP2↑, 1,   TumCMig↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 2,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: MGMT, O^6^-methylguanine-DNA methyltransferase
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1087  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page