Database Query Results : , , AVOs

AVOs, Acidic vesicular organelles: Click to Expand ⟱
Source:
Type:
Acidic vesicular organelles (AVOs) are cellular compartments that are characterized by their low pH and include lysosomes, autophagosomes, and autolysosomes. They play a central role in several cellular processes, including degradation of intracellular components, recycling of cellular constituents, and autophagy.

Autophagy and Its Role in Cancer
Cell Survival Mechanism:
Autophagy is often activated under stressful conditions such as nutrient deprivation, hypoxia, or chemotherapy. By degrading and recycling damaged proteins and organelles, autophagy helps cancer cells survive under adverse conditions.
Tumor Suppressor Function:
In early stages of tumorigenesis, autophagy can limit genomic instability and inflammation by removing damaged organelles and misfolded proteins. Thus, it can act as a barrier to malignant transformation.
Tumor Promotion:
In established tumors, autophagy may support cancer cell survival. Enhanced autophagy can provide energy and metabolic substrates, thereby facilitating tumor growth and resistance to therapy.
Scientific Papers found: Click to Expand⟱
313- Api,    Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
- in-vitro, Thyroid, BCPAP
LC3s↝, p62↓, ROS↑, TumCCA↑, CDC25↓, TumAuto↑, Beclin-1↑, AVOs↑, DNAdam↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,  

Autophagy & Lysosomes ⓘ

AVOs↑, 1,   Beclin-1↑, 1,   LC3s↝, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AVOs, Acidic vesicular organelles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1088  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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