Database Query Results : , , Ikaros

Ikaros, Ikaros: Click to Expand ⟱
Source:
Type:
Karos is a zinc finger transcription factor encoded by the IKZF1 gene. It is primarily known for its important roles in:
  Hematopoiesis and lymphoid lineage development.
  Regulation of gene expression during immune cell differentiation.
  Chromatin remodeling and modulation of key signaling pathways in the immune system.
Because of its central role in lymphocyte development, Ikaros has been studied extensively in the context of hematological malignancies.

In a significant subset of B-cell ALL, particularly those with high-risk features, genomic alterations in IKZF1 are frequently observed. These genetic abnormalities often lead to reduced or dysfunctional Ikaros protein.
In ALL, particularly pediatric and adult cases, IKZF1 deletions or mutations are associated with a poor prognosis. This is reflected in shorter event-free survival, higher relapse rates, and overall poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
315- Api,    Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer
- vitro+vivo, PC, Panc02
CK2↓, CD4+↑, CD8+↑, Ikaros↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Metal & Cofactor Biology ⓘ

Ikaros↑, 1,  

Cell Death ⓘ

CK2↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Ikaros, Ikaros
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1089  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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