Database Query Results : , , FADD

FADD, FADD: Click to Expand ⟱
Source:
Type:
FADD (Fas-associated protein with death domain) is a protein that plays a crucial role in the apoptotic signaling pathway, particularly in the process of programmed cell death. It is involved in the signaling of death receptors, such as Fas (CD95), which, when activated, can lead to apoptosis in cells.
FADD has a dual role. On one hand, it can promote apoptosis in response to certain signals, which is a mechanism that can prevent the proliferation of cancer cells. On the other hand, some cancer cells may exploit the apoptotic pathways to evade cell death, leading to tumor survival and growth.

Expression: FADD is often expressed in breast cancer cells, and its levels can vary among different subtypes.
Prognosis: High levels of FADD expression have been associated with increased apoptosis in response to certain therapies, which may correlate with better treatment outcomes. However, in some contexts, FADD can also promote cell survival, complicating its role in prognosis.
Scientific Papers found: Click to Expand⟱
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
722- Bor,    Boric acid as a promising agent in the treatment of ovarian cancer: Molecular mechanisms
- in-vitro, Ovarian, MDAH-2774
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, ROS↑, miR-21↓, miR-130a↓, Casp8∅, Casp10∅, cycD1/CCND1∅, CDK6∅, CDK4∅, FADD∅, DR4∅, DR5∅,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↓, 1,   MDA↑, 1,   ROS↑, 7,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

BOK↑, 2,   MMP↓, 4,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   AMPK↑, 3,   cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PDK1↓, 1,   PKM2↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 2,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 7,   BAD↓, 1,   BAD↑, 1,   BAX↑, 5,   Bcl-2↓, 5,   Bcl-2↑, 1,   BID↑, 4,   Casp↑, 1,   Casp10∅, 1,   cl‑Casp12↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 4,   Casp8∅, 1,   pro‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 5,   DR4↑, 1,   DR4∅, 2,   DR5↑, 7,   DR5∅, 1,   FADD↑, 10,   FADD∅, 1,   Fas↑, 6,   FasL↑, 7,   hTERT/TERT↓, 1,   JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 4,   NAIP↓, 2,   p27↑, 1,   p38↑, 1,   survivin↓, 1,   Telomerase↓, 1,   TRAIL↑, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 3,   CDK4∅, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 1,   cycD1/CCND1∅, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   FOXM1↓, 1,   GSK‐3β↑, 1,   HH↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 3,   STAT3↓, 1,   p‑STAT3↓, 1,   TumCG↓, 2,  

Migration ⓘ

Akt2↓, 1,   AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 2,   CAFs/TAFs↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   miR-130a↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail?, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 4,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   ATF4↑, 1,   Hif1a↓, 3,   NO↑, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL4↓, 1,   M2 MC↓, 1,   NF-kB↓, 2,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,   CDK6∅, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   eff↓, 2,   eff↑, 7,  

Clinical Biomarkers ⓘ

FOXM1↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   Risk↓, 1,  
Total Targets: 138

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDHA↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   toxicity↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: FADD, FADD
2 Baicalein
2 chitosan
2 Selenium
1 Artemisinin
1 Boron
1 Selenate
1 Chrysin
1 Luteolin
1 Silymarin (Milk Thistle) silibinin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:109  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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