Database Query Results : , , decorin

decorin, decorin: Click to Expand ⟱
Source:
Type:
Decorin is a small leucine‐rich proteoglycan found in the extracellular matrix that plays a multifaceted role in regulating cell growth, angiogenesis, and collagen fibrillogenesis. Its interaction with growth factors (such as transforming growth factor‐β [TGF‐β]), receptor tyrosine kinases, and other extracellular molecules contributes to its ability to influence tumor cell behavior. Numerous studies have investigated the expression of decorin in various cancers, revealing that its levels can influence prognosis.

Decorin is generally downregulated in the tumor microenvironment.
– Lower decorin levels have been correlated with desmoplasia and a more fibrotic, aggressive tumor phenotype, suggesting poorer prognosis.
Scientific Papers found: Click to Expand⟱
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

decorin↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCL9↓, 1,   IFN-γ↓, 1,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   MIP-1β↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: decorin, decorin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1092  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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