Database Query Results : , , CXCL9

CXCL9, CXCL9: Click to Expand ⟱
Source:
Type:
CXCL9 (also known as monokine induced by gamma interferon, MIG) is a chemokine that plays a critical role in immune surveillance by recruiting activated T cells, natural killer (NK) cells, and other leukocytes to the tumor microenvironment. Its expression is often regulated by interferon‐γ (IFN-γ) and other inflammatory cytokines.
– CXCL9 is often expressed by both tumor and stromal cells.
– High expression can be found in tumor microenvironments.
– Elevated CXCL9 expression is generally linked to a favorable prognosis due to effective immune cell recruitment.

Strategies that boost CXCL9 expression or restore its activity in immunologically "cold" tumors are being explored as potential means to enhance the efficacy of immunotherapies.
Scientific Papers found: Click to Expand⟱
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

decorin↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCL9↓, 1,   IFN-γ↓, 1,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   MIP-1β↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CXCL9, CXCL9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1093  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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