Database Query Results : , , selectivity

selectivity, selectivity: Click to Expand ⟱

Source:

Type:

The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability

Scientific Papers found: Click to Expand⟱

5271-

3BP,

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Review,

Var,

selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,

5281-

3BP,

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

Case Report,

Var,

Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,

5280-

3BP,

Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting

in-vitro,

PC,

mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,

5278-

3BP,

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

Caco-2

in-vitro,

CRC,

SW48

ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,

5277-

3BP,

3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model

in-vivo,

PC,

Panc02

mouse model

HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,

5461-

AF,

Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

MCF10

Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,

375-

AgNPs,

ALA,

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer

in-vitro,

PC,

Bxpc-3

 we used α-lipoic acid concentrations of 0.5 and 1 mM

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

in-vivo,

NA,

dropping 200 µL or 400 µL of a 14 ppm AgNP solution, 200 µL or 400 µL of a 0.5 mM α-lipoic acid solution, or both solutions together on the chorioallantoic membrane (CAM)

chick embryos

mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

L02

tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

GL26

in-vitro,

Cerv,

HeLa

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4402-

AgNPs,

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

in-vitro,

BC,

BT549

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

MCF10

TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,

4397-

AgNPs,

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

NA,

Wounds,

 99 nm, with a zeta potential of −6 mV

selectivity↑, tumCV↓, antiOx↑, Inflam↓,

4393-

AgNPs,

Nanotoxic Effects of Silver Nanoparticles on Normal HEK-293 Cells in Comparison to Cancerous HeLa Cell Line

in-vitro,

Cerv,

HeLa

1.98 µL/mL

in-vitro,

Nor,

HEK293

0.622 µL/mL

selectivity↓,

4388-

AgNPs,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

in-vitro,

Cerv,

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4422-

AgNPs,

Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications

in-vitro,

Cerv,

HeLa

AntiCan↑, selectivity↑,

4421-

AgNPs,

Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells

in-vitro,

Cerv,

selectivity↑, eff↝, other↝,

4413-

AgNPs,

Anzaroot,

Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells

in-vitro,

BC,

MCF-7

12.35 μg/mL

The IC50 value for root extract-mediated SNPs was found to be 21.73 μg/mL

chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,

4411-

AgNPs,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

in-vitro,

Lung,

A549

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4431-

AgNPs,

doxoR,

Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy

in-vitro,

BC,

4T1

PA-AgNPs have an average hydrodynamic diameter of 130 nm

in-vivo,

BC,

4T1

in-vitro,

Nor,

3T3

AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,

4429-

AgNPs,

Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles

in-vitro,

Liver,

HepG2

*toxicity↝, selectivity↑, mt-ROS↑,

4363-

AgNPs,

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

in-vivo,

fibroS,

particles was approximately 10 nm

LACA mice

TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,

4433-

AgNPs,

Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

L02

selectivity↑, selectivity↓, mt-ROS↑,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

in-vitro,

BC,

MCF-7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4376-

AgNPs,

Interaction of multi-functional silver nanoparticles with living cells

in-vitro,

Nor,

L929

in-vitro,

Lung,

A549

eff↑, selectivity↑,

4371-

AgNPs,

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

in-vitro,

Liver,

HUH7

20−50 nm

eco-friendly approach silver nanoparticles (AgNPs) using root extracts of Beta vulgaris L.

ROS↑, selectivity↑, DNAdam↑, Apoptosis↑, GSH↓, lipid-P↑, MMP↓, DNAdam↑,

4365-

AgNPs,

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Review,

Var,

ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

4558-

AgNPs,

Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

in-vitro,

PC,

PANC1

3.19 ug/mL

ROS↑, selectivity↑, NO↑, SOD↓, GPx4↓, Catalase↓, TumCCA↑, MMP↓,

4555-

AgNPs,

Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Liver,

HepG2

*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,

4551-

AgNPs,

Fenb,

Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy

in-vivo,

Lung,

mice

eff↑, eff↑, Apoptosis↑, selectivity↓, TumCG↓,

4541-

AgNPs,

RosA,

Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities

in-vitro,

Nor,

WI38

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

PANC1

*antiOx↑, TumCD↓, selectivity↑,

4540-

AgNPs,

VitC,

Silver nanoparticles from ascorbic acid: Biosynthesis, characterization, in vitro safety profile, antimicrobial activity and phytotoxicity

in-vitro,

Nor,

*Bacteria↓, *selectivity↑,

4584-

AgNPs,

Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells

in-vitro,

Pca,

DU145

selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27↑, P21↑, AntiCan↑,

4573-

AgNPs,

Bioactive silver nanoparticles derived from Carica papaya floral extract and its dual-functioning biomedical application

in-vitro,

Var,

MCF-7

21.25 ± 1.14 µg/mL

NA,

HEK293

169.96 ± 2.3 µg/mL

toxicity↓, Bacteria↓, selectivity↑,

5147-

AgNPs,

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells

in-vitro,

Lung,

A549

TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,

5340-

Ajoene,

Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB

in-vitro,

AML,

Apoptosis↑, selectivity↑, H2O2↑, NF-kB↑,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

2000-

AL,

Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds

in-vitro,

BC,

MDA-MB-231

5–20 mg/mL

13.69 mg/mL

in-vitro,

BC,

MCF-7

5–20 mg/mL5–20 mg/mL

15.35 mg/mL

in-vitro,

Nor,

selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,

5356-

AL,

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

Review,

GC,

Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

Review,

NA,

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

3442-

ALA,

α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

C4-2B

in-vitro,

Nor,

3T3

tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,

3454-

ALA,

Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness

in-vitro,

BC,

MCF-7

(0.5 mM, 1 mM, 2.5 mM, and 5 mM)

in-vitro,

BC,

MDA-MB-231

TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,

5326-

ALC,

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

vitro+vivo,

Liver,

HepG2

mice

TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,

1999-

Api,

doxoR,

Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation

in-vitro,

Nor,

NRK52E

in-vitro,

Nor,

MPC5

in-vitro,

BC,

4T1

in-vivo,

NA,

APG (125, 250, and 500 mg/kg) for two weeks,

mice

neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,

1548-

Api,

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Review,

Colon,

*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,

1559-

Api,

Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

Dose↓, selectivity↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

2584-

Api,

Chemo,

The versatility of apigenin: Especially as a chemopreventive agent for cancer

Review,

Var,

ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,

2316-

Api,

The interaction between apigenin and PKM2 restrains progression of colorectal cancer

in-vitro,

CRC,

LS174T

in-vitro,

CRC,

HCT8

in-vivo,

CRC,

TumCP↓, PKM2↓, Glycolysis↓, TumCG↑, selectivity↑,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Review,

Var,

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

2570-

ART/DHA,

Discovery, mechanisms of action and combination therapy of artemisinin

Review,

Nor,

*BioAv↓, *Half-Life↓, *toxicity↓, *ROS↑, GSH↓, selectivity↑,

2572-

ART/DHA,

SRF,

Antileukemic efficacy of a potent artemisinin combined with sorafenib and venetoclax

in-vitro,

AML,

CHOP↑, Mcl-1↓, ChemoSen↑, selectivity↑,

2574-

ART/DHA,

Artemisinin: A Promising Adjunct for Cancer Therapy

Review,

Var,

selectivity↑, eff↑,

2581-

ART/DHA,

PB,

Synergistic cytotoxicity of artemisinin and sodium butyrate on human cancer cells

in-vitro,

AML,

Molt-4 cells

eff↑, selectivity↑,

2582-

ART/DHA,

5-ALA,

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

in-vivo,

CRC,

HCT116

mouse xenograft CRC model

in-vitro,

CRC,

HCT116

eff↑, ROS↑, selectivity↑, TumCG↓, toxicity↓,

5381-

ART/DHA,

Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

NCM460

in-vitro,

CRC,

HT29

in-vitro,

CRC,

HCT8

Ferroptosis↑, CYP24A1↓, Ca+2↑, SCD1↓, FAO↑, lipid-P↑, eff↑, selectivity↑, other?,

2003-

Ash,

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

in-vitro,

Pca,

PC3

2 μM WA

in-vitro,

Pca,

DU145

in-vitro,

Nor,

TIG-1

in-vitro,

PC,

LNCaP

TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,

5396-

Ash,

Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology

Review,

Var,

selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,

3172-

Ash,

Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis

in-vitro,

HCC,

HepG2

in-vitro,

Nor,

HL7702

Keap1↑, NRF2↓, EMT↓, TumCP↓, TumCI↓, selectivity↑, *toxicity↓, ROS↑, MDA↑, GSH↓, Ferroptosis↑,

1142-

Ash,

Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer

Review,

BC,

MCF-7

typ 2-5uM

Ashwagandha was well tolerated at a dose of 300 mg per day in an eight-week study [147]. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective

NA,

BC,

MDA-MB-231

NA,

Nor,

HMEC

Apoptosis↑, ROS↑, DNAdam↑, OXPHOS↓, *ROS∅, Bcl-2↓, XIAP↓, survivin↓, DR5↑, IKKα↓, NF-kB↓, selectivity↑, *ROS∅, eff↓, Paraptosis↑,

3163-

Ash,

Rad,

Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis

*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,

4822-

ASTX,

Rad,

Astaxanthin Synergizes with Ionizing Radiation (IR) in Oral Squamous Cell Carcinoma (OSCC)

tumCV↓, selectivity↑, RadioS↑, GPx4↓, Ferroptosis↑,

4818-

ASTX,

MEL,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,

4810-

ASTX,

Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

in-vitro,

BC,

MDA-MB-231

10 μM to 25 μM and 50 μM,

in-vitro,

Nor,

MCF10

TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,

4981-

ATV,

Crosstalk between Statins and Cancer Prevention and Therapy: An Update

Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,

4986-

ATV,

Dipy,

The combination of statins and dipyridamole is effective preclinically in AML, MM, and breast cancer

Review,

Var,

HMG-CoA↓, AntiAg↑, eff↑, Apoptosis↑, selectivity↑, *toxicity↓, TumCG↓, PDE4↓, other↑,

5248-

Ba,

BA,

doxoR,

Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

HUVECs

toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,

5250-

Ba,

Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment

Review,

Var,

Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp↓, BioAv↑, selectivity↑,

2479-

Ba,

Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells

in-vitro,

HCC,

SW480

 40 μmol/L

in-vitro,

Pca,

PC3

12LOX↓, DR5↑, CHOP↑, ROS↑, *ROS∅, selectivity↑,

2615-

Ba,

The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways

Review,

Var,

*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,

1533-

Ba,

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

in-vitro,

BrCC,

MCF-7

85μM for 24 h

in-vitro,

Nor,

MCF10

557uM

tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,

1523-

Ba,

Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression

in-vitro,

OS,

MG63

(12.5, 25, and 50 μM)

in-vitro,

Nor,

hFOB1.19

TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,

2023-

BBR,

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

in-vitro,

Colon,

0-100uM

in-vitro,

Nor,

YAMC

TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,

2022-

BBR,

GoldNP,

Rad,

Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

in-vitro,

Liver,

SMMC-7721 cell

in-vitro,

Nor,

HL7702

*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,

2021-

BBR,

Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways

Review,

NA,

*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,

5178-

BBR,

Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,

2700-

BBR,

Cell-specific pattern of berberine pleiotropic effects on different human cell lines

in-vitro,

GBM,

U343

in-vitro,

GBM,

MIA PaCa-2

in-vitro,

Nor,

HDFa

selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,

2707-

BBR,

Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway

in-vitro,

Liver,

HepG2

concentrations >25 µM after 48 h

in-vitro,

BC,

MCF-7

GLUT1↓, Akt↓, mTOR↓, ATP↓, GlucoseCon↓, TumCP↓, Warburg↓, selectivity↑, TumCCA↑, Glycolysis↓,

2686-

BBR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

Nor,

Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,

943-

BetA,

Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

in-vivo,

NA,

mouse model

Glycolysis↓, lactateProd↓, GlucoseCon↓, ECAR↓, cMyc↓, LDHA↓, p‑PDK1↓, PDK1↓, Cav1↑, *Glycolysis↑, selectivity↑, OCR↓, OXPHOS↓,

2718-

BetA,

The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis

in-vitro,

AML,

U937

TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2729-

BetA,

Betulinic acid in the treatment of tumour diseases: Application and research progress

Review,

Var,

ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,

2732-

BetA,

Chemo,

Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78

in-vitro,

BC,

MCF-7

18.411

in-vitro,

BC,

MDA-MB-231

20.465 μM

in-vitro,

Nor,

MCF10

ChemoSen↑, selectivity↑, GRP78/BiP↑, ER Stress↑, PERK↑, Ca+2↑, Cyt‑c↑, BAX↑, Bcl-2↓,

2735-

BetA,

Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications

Review,

Var,

mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,

2747-

BetA,

Betulinic acid, a natural compound with potent anticancer effects

Review,

Var,

selectivity↑, Cyt‑c↑, *toxicity↓, TOP1↓, NF-kB↓, ROS↑, RadioS↑, ChemoSen↑,

2752-

BetA,

Betulinic acid: a natural product with anticancer activity

Review,

Var,

selectivity↑, ChemoSen↑, RadioS↑, MMP↓, cl‑Casp3↑, Cyt‑c↑, ROS↑, NF-kB↑, TOP1↓,

696-

Bor,

Nothing Boring About Boron

Review,

Var,

>3mg

upper intake level (UL) of 20 mg/d

*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,

738-

Bor,

Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways

in-vitro,

GBM,

U251

in-vitro,

GBM,

A172

in-vitro,

Nor,

SVGp12

TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,

3506-

Bor,

Boron Chemistry for Medical Applications

Review,

NA,

radioP↑, selectivity↑,

3513-

Bor,

Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status

in-vitro,

Pca,

DU145

in-vitro,

Nor,

MEF

NRF2↑, selectivity↑, NQO1↑, GCLC↑, HO-1↑, TumCP↓,

2024-

Bos,

Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro

in-vitro,

BC,

MCF-7

 101.1

in-vitro,

Nor,

MCF10

275.2

MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,

1646-

CA,

Caffeic acid: a brief overview of its presence, metabolism, and bioactivity

Review,

Nor,

*BioAv↓, ROS⇅, selectivity↑, other∅, VEGF↓, MMP2↓, MMP9↓,

1650-

CA,

Adjuvant Properties of Caffeic Acid in Cancer Treatment

Review,

Var,

ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,

3032-

CA,

Carnosic Acid Induces Apoptosis Through Reactive Oxygen Species-mediated Endoplasmic Reticulum Stress Induction in Human Renal Carcinoma Caki Cells

in-vitro,

Kidney,

Caki-1

cl‑PARP↑, ROS↑, ER Stress↑, ATF4↑, CHOP↑, selectivity↑,

5203-

CAP,

Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells

in-vitro,

OS,

74.4 μM/mL

tumCV↓, TNF-α↓, NF-kB↓, selectivity↑, Apoptosis↑, TumCMig↓,

2014-

CAP,

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

Bxpc-3

150uM

in-vitro,

Nor,

HPDE-6

150uM

normal pancreatic epithelial cells were resistant to the effects of capsaicin.

in-vivo,

PC,

AsPC-1

mice orally fed with 2.5 mg/kg capsaicin

mice, 2.5 mg/kg capsaicin was given to mice by oral gavage, which is 0.202 mg/kg when converted to human equivalent dose (HED) and equates to 13.2 mg dose of capsaicin for a 60 kg person

ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,

2015-

CAP,

CUR,

urea,

Anti-cancer Activity of Sustained Release Capsaicin Formulations

Review,

Var,

AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,

2018-

CAP,

MF,

Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma

Review,

HCC,

TRPV1↑, eff↑, Akt↓, mTOR↓, p‑STAT3↑, MMP2↑, ER Stress↑, Ca+2↑, ROS↑, selectivity↑, MMP↓, eff↑,

2019-

CAP,

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

Review,

Var,

chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,

2020-

CAP,

Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale

Review,

Var,

AntiTum↑, selectivity↑, TRPV1↑, MMP↓, Ca+2↑, ER Stress↑, angioG↓, Casp3?, cl‑PARP↑, selectivity↑, ROS↑, *ROS∅, selectivity↑,

4481-

Chit,

Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy

Review,

Var,

*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,

4489-

Chit,

SeNPs,

Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy

in-vitro,

GBM,

U87MG

diameters of Cs-SeNPs with chitosan contents of 0.1, 0.15, and 0.2% were 88.66 ± 0.65, 88.90 ± 0.57, and 91.45 ± 2.57 nm

TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,

4478-

Chit,

Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA

in-vitro,

BC,

MDA-MB-231

290 μg ml−1

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,

2806-

CHr,

Se,

Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy

in-vitro,

Var,

eff↑, selectivity↑, Dose↝, TrxR↓, GSH↓, MMP↓, ROS↑, H2O2↑,

2784-

CHr,

Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)

Review,

Var,

Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,

2786-

CHr,

Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives

Review,

Var,

Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,

1586-

Citrate,

Extracellular Citrate Is a Trojan Horse for Cancer Cells

in-vitro,

Liver,

HepG2

<5mM(low), vs >10,25mM(high)

17mM

Dose?, ac‑H4↓, lipidDe↓, ACLY↓, selectivity↑, *ACLY∅, Glycolysis↓, NADH↓, OAA↑, other↑,

1580-

Citrate,

Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway

in-vitro,

Pca,

PC3

 (0-3 mM)

in-vivo,

PC,

50 mg/kg/day, i.p.)

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

WPMY-1

 (0-3 mM)

Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1↑, TumAuto↑, CaMKII ↓,

1574-

Citrate,

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

in-vitro,

Lung,

A549

5,10,15mM

in-vitro,

Melanoma,

WM983B

in-vivo,

NA,

4 g/kg citrate twice a day for 4 week

mice. Plasma levels in chronically treated animals were approximately 3 mM

TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,

4763-

CoQ10,

Chemo,

doxoR,

Effect of Coenzyme Q10 on Doxorubicin Cytotoxicity in Breast Cancer Cell Cultures

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

ChemoSen∅, antiNeop∅, *cardioP↑, Dose↝, selectivity↑, TumCG∅, TumCG∅, Apoptosis∅,

4768-

CoQ10,

Role of coenzymes in cancer metabolism

Review,

Var,

Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,

1642-

Cu,

HCAs,

Copper-assisted anticancer activity of hydroxycinnamic acid terpyridine conjugates on triple-negative breast cancer

in-vitro,

BC,

4T1

(IC50 ∼ 3.5 ± 2.5 μM

in-vitro,

Nor,

L929

IC50 ∼ 15 ± 5 μM

tumCV↓, selectivity↑,

1602-

Cu,

A simultaneously GSH-depleted bimetallic Cu(ii) complex for enhanced chemodynamic cancer therapy†

in-vitro,

BC,

MCF-7

3.2uM

in-vitro,

BC,

4T1

3.3uM

in-vitro,

Lung,

A549

4uM

in-vitro,

Liver,

HepG2

3.5uM

eff↑, GSH↓, H2O2↑, ROS↑, *BioAv↑, selectivity↑, TumCCA↑, Apoptosis↑, Fenton↑, *toxicity?,

1600-

Cu,

Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis

Review,

NA,

ER Stress↑, ROS↑, AntiTum↑, GSH↓, Ferroptosis↑, selectivity↑, GSH/GSSG↓, *ROS∅, eff↑,

1570-

Cu,

Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector

Review,

NA,

selectivity↑, antiOx↑, ROS↑, eff↑, GSH↓, lipid-P↑, Catalase↓, SOD↓, other↑,

1572-

Cu,

Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

Review,

NA,

eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

1596-

Cu,

CDT,

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Review,

NA,

TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,

1980-

CUR,

Rad,

Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells

in-vitro,

Cerv,

HeLa

10 µM

in-vitro,

Laryn,

FaDu

10 µM

selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,

1979-

CUR,

Rad,

Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase

in-vitro,

Lung,

A549

eff↑, ROS↑, GSH/GSSG↓, TrxR↓, selectivity↑,

2304-

CUR,

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

in-vitro,

Lung,

H1299

0–20 μM curcumin for 24

in-vitro,

BC,

MCF-7

in-vitro,

Cerv,

HeLa

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,

4650-

CUR,

Curcumin and cancer stem cells: curcumin has asymmetrical effects on cancer and normal stem cells

Review,

Var,

SCD1↓, IL6↓, IL8↓, IL1↓, *selectivity↑, Wnt↝, NOTCH↝, HH↝, FAK↝,

1875-

DCA,

Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells

in-vitro,

neuroblastoma,

in-vivo,

NA,

five mice were treated with 2.5 mg/kg/
dose of DCA, 14 mice were treated with 25 mg/kg/dose

mice

selectivity↑, AntiCan↑, TumVol↓, PDKs↓, mt-OXPHOS↑, MMP↓, Glycolysis↓, toxicity↓, Warburg↓, ROS↑, eff↑,

1864-

DCA,

MET,

Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells

in-vitro,

BC,

MCF-7

DCA (2.5 mM) and metformin (1 mM)

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,

1881-

DCA,

Chemo,

Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report

in-vitro,

NA,

HT1080

in-vitro,

NA,

WI38

Case Report,

Var,

eff↑, selectivity↑, OS↑,

1873-

DCA,

Dual-targeting of aberrant glucose metabolism in glioblastoma

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

U251

PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,

1868-

DCA,

MET,

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy

Case Report,

NA,

eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,

4901-

DCA,

Sal,

Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer

Review,

NSCLC,

Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,

5195-

DCA,

Rad,

Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

in-vitro,

BC,

4T1

in-vitro,

BC,

EMT6

PDKs↑, ROS↑, p‑PDH↓, ECAR↓, lactateProd↓, selectivity↓, RadioS↑,

5196-

DCA,

Dichloroacetate induces apoptosis in endometrial cancer cells

in-vitro,

Var,

selectivity↑, MMP↓, survivin↓, Ca+2↓, P53↑, PDK1↓, PDH↑, Glycolysis↓, OXPHOS↑, ROS↑, Cyt‑c↑, Apoptosis↑, Casp↑, tumCV↓, PUMA↑,

4455-

DFE,

Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest

in-vitro,

BC,

MCF-7

5, 10, 15, 20 and 25 mg/ml) of MEAD for 24, 48 and 72 h

18.2 mg/ml

in-vitro,

Nor,

3T3

 50 mg/ml

TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,

4454-

DFE,

Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells

in-vitro,

Liver,

HepG2

16.78 mg/mL

ROS↑, MMP↓, TumCCA↑, Apoptosis↑, selectivity↑, MMP↓, TumCCA↑,

1845-

dietFMD,

Fasting and fasting mimicking diets in cancer prevention and therapy

Review,

Var,

eff↑, selectivity↑, ChemoSen↑,

1849-

dietFMD,

The emerging role of fasting-mimicking diets in cancer treatment

Review,

Var,

TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,

1851-

dietFMD,

Chemo,

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

in-vitro,

GBM,

LN229

in-vitro,

neuroblastoma,

SH-SY5Y

selectivity↑, selectivity↑, ROS↑, DNAdam↑, BG↓,

1861-

dietFMD,

Chemo,

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

in-vitro,

Colon,

CT26

in-vivo,

NA,

selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,

1810-

dietKeto,

Oxy,

The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

in-vivo,

Var,

mice

BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,

2268-

dietMet,

Methionine dependency and cancer treatment

Review,

Var,

ChemoSen↑, *eff↑, selectivity↑, eff↑,

2263-

dietMet,

Methionine Restriction and Cancer Biology

Review,

Var,

AntiCan↑, TumCP↓, TumCG↓, selectivity↑, ChemoSen↓, RadioS↑, Insulin↓, *GlucoseCon↑, *ROS↓, *antiOx↑, *GSH↑, GSH↑, eff↑, polyA↓, TS↓, Raf↓, Akt↓, Casp9↑, Bak↑, P21↑, p27↑, Insulin↓, IGF-1↓,

2264-

dietMet,

Methionine restriction for cancer therapy: From preclinical studies to clinical trials

Review,

Var,

TumCP↓, *ROS?, ChemoSen↑, RadioS↑, eff↑, ROS↑, selectivity↑, TS↓, eff↑,

4984-

Dipy,

ATV,

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

in-vitro,

AML,

eff↑, Apoptosis↑, selectivity↑, TumCG↓, HMG-CoA↓, HMGCR↑,

4915-

DSF,

Cu,

Disulfiram: A novel repurposed drug for cancer therapy

Review,

Var,

ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

in-vitro,

HCC,

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

4832-

EA,

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

*antiOx↑, *AntiCan↑, TumCMig↓, angioG↓, ChemoSen↑, RadioS↑, *chemoP↑, *BioAv↓, eff↓, selectivity↑, MMP2↓, MMP9↓, VEGF↓, TumCCA↑, Apoptosis↑, ROS↑, BioAv↑,

1605-

EA,

Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

Review,

Var,

*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,

1608-

EA,

Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity

in-vitro,

Cerv,

HeLa

35 μg/mL

in-vitro,

Liver,

HepG2

220ug/mL

in-vitro,

BC,

MCF-7

75 ug/mL

in-vitro,

Lung,

A549

242um/mL

in-vitro,

Nor,

HUVECs

258um/mL

eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,

1613-

EA,

Ellagitannins in Cancer Chemoprevention and Therapy

Review,

Var,

ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,

3238-

EGCG,

Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications

Review,

Var,

Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2↓, angioG↓,

3214-

EGCG,

EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway

in-vitro,

Nor,

MRC-5

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

HEK293

in-vitro,

BC,

MDA-MB-231

in-vitro,

CRC,

HCT116

mTOR↓, AMPK↑, selectivity↑, ROS↑, selectivity↑, HO-1↓, *NRF2↑, NRF2↓, *HO-1↑,

1514-

EGCG,

Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture

in-vitro,

Cerv,

HeLa

1-50uM

in-vitro,

Nor,

MCF10

selectivity↑, *toxicity∅, TumCG↓, NADHdeh?, eff↑, ENOX2↓, Dose?,

1503-

EGCG,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

Review,

NA,

IC50 values ranging from 0.21 to 0.47 μM

selectivity↑, DNMT1↓, RECK↑, MMPs↓, TumCI↓, angioG↓, TumMeta↓, HATs↓, IκB↑, NF-kB↓, IL6↓, COX2↓, NOS2↓, ac‑H3↑, ac‑H4↑, eff↑,

1515-

EGCG,

Phen,

Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells

in-vitro,

Cerv,

HeLa

0.003 uM

in-vitro,

Nor,

MCF10

exceeded 20 uM

 note IC50 not reached for normal cells

in-vitro,

BC,

BT20

0.01 uM

selectivity↑, ENOX2↓, NADH↑, SK↓, eff↑, aSmase↑,

2309-

EGCG,

Chemo,

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts

in-vitro,

PC,

MIA PaCa-2

(20–100 μM) for 72 h

in-vitro,

Nor,

HPNE

in-vitro,

PC,

PANC1

in-vivo,

NA,

mice

TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,

5223-

EMD,

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

in-vitro,

CRC,

DLD1

in-vitro,

Nor,

CCD841

tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,

2497-

Fenb,

In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells

in-vitro,

GBM,

Dose?, selectivity↑, TumCD↑, α-tubulin↓,

2496-

Fenb,

Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells

in-vitro,

NSCLC,

A549

1.6 μm

in-vitro,

NSCLC,

H460

1.2 uM

TumCG↓, selectivity↑, P53↑, IKKα↑, ER Stress↑, GRP78/BiP↑, CHOP↑, ATF3↑, IRE1↑, NOXA↑, ROS↑, MMP↓, Cyt‑c↑, selectivity↑, eff↝,

2851-

FIS,

Apoptosis induction in breast cancer cell lines by the dietary flavonoid fisetin

in-vitro,

BC,

MDA-MB-468

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

in-vitro,

BC,

SkBr3

in-vitro,

Nor,

tumCV↓, selectivity↑, TumCCA↑, Apoptosis↑, ROS∅,

2852-

FIS,

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

Review,

CRC,

Risk↓, P53↑, MDM2↓, COX2↓, Wnt↓, NF-kB↓, CDK2↓, CDK4↓, p‑RB1↓, cycE/CCNE↓, P21↑, NRF2↓, ROS↑, Casp8↑, Fas↑, TRAIL↑, DR5↑, MMP↓, Cyt‑c↑, selectivity↑, P450↝, GSTs↝, RadioS↑, Inflam↓, β-catenin/ZEB1↓, EGFR↓, TumCCA↑, ChemoSen↑,

2860-

FIS,

Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways

in-vitro,

PC,

PANC1

in-vitro,

PC,

Bxpc-3

in-vitro,

Nor,

hTERT-HPNE

in-vivo,

NA,

mice

AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,

2824-

FIS,

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Review,

Var,

*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,

2833-

FIS,

AgNPs,

Glucose-capped fisetin silver nanoparticles induced cytotoxicity and ferroptosis in breast cancer cells: A molecular perspective

in-vitro,

BC,

MDA-MB-231

11.275 ± 0.197 μg/mL

MMP↓, ROS↑, NRF2↑, NOX↑, selectivity↑,

2842-

FIS,

Fisetin inhibits cellular proliferation and induces mitochondria-dependent apoptosis in human gastric cancer cells

in-vitro,

GC,

AGS

TumCCA↑, CDK2↓, P53↑, selectivity↑, MMP↓, DNAdam↑, cl‑PARP↑, mt-ROS↑, eff↓, survivin↓,

4023-

FulvicA,

Shilajit (Mumio) Elicits Apoptosis and Suppresses Cell Migration in Oral Cancer Cells through Targeting Urokinase-type Plasminogen Activator and Its Receptor and Chemokine Signaling Pathways

in-vitro,

Oral,

tumCV↓, selectivity↑, Apoptosis↑, uPA↓, TumCMig↓, Dose↝, CXCc↓,

4025-

FulvicA,

Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment

in-vitro,

Bladder,

T24/HTB-9

Review,

AD,

tumCV↓, selectivity↑, TumCCA↑, other↝, *neuroP↑, *memory↑, *tau↓, *other↝, *lipid-P↓, *VitC↑, *antiOx↑,

4027-

FulvicA,

Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

31.3±0.4 µg/ml

in-vitro,

BC,

MCF-7

 40±0.8µg/ml

in-vitro,

Nor,

MCF10

89.66±1.2 µg/ml

tumCV↓, selectivity↑, TGF-β↓, Twist↓, NOTCH1↓, CTNNB1↓, Src↓, E-cadherin↑, EMT↓, TumMeta↓, BioAv↑,

5149-

GamB,

Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells

in-vitro,

lymphoma,

JeKo-1

TumCG↓, Apoptosis↑, selectivity↑, MMP↓, Casp3↑, Casp9↑, Casp8↑, Bax:Bcl2↑,

1971-

GamB,

Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-435

1.5 μM

in-vitro,

BC,

MDA-MB-468

2.35 μM

in-vivo,

NA,

injections of saline or GA (4 or 8 mg/kg) twice

mice

Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,

4513-

GLA,

Antineoplastic Effects of Gamma Linolenic Acid on Hepatocellular Carcinoma Cell Lines

in-vitro,

Liver,

HUH7

TumCP↓, ROS↑, Apoptosis↑, HO-1↑, Trx↑, lipid-P↑, eff↓, MMP↓, DNAdam↑, selectivity↑,

4510-

GLA,

Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies

Review,

NA,

Apoptosis↑, selectivity↑, eff↓, ROS↑, lipid-P↑, P53↑, radioP↑, chemoP↑,

4509-

GLA,

Gamma-linolenic Acid (GLA) sensitizes pancreatic cancer cells to gemcitabine

in-vitro,

PC,

PANC1

tumCV↑, selectivity↑, ChemoSen↑,

1904-

GoldNP,

AgNPs,

Unveiling the Potential of Innovative Gold(I) and Silver(I) Selenourea Complexes as Anticancer Agents Targeting TrxR and Cellular Redox Homeostasis

in-vitro,

Lung,

H157

in-vitro,

BC,

MCF-7

in-vitro,

Colon,

HCT15

in-vitro,

Melanoma,

A375

TrxR↓, selectivity↑, eff↑, eff↝, ROS↑, MMP↓, Apoptosis↑, eff↑,

841-

Gra,

The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach

in-vitro,

CRC,

HT-29

1.62ug/ml@48hr

in-vitro,

Nor,

CCD841

32.51μg/ml@48 h

normal human colon cells

PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,

2437-

Gra,

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

in-vitro,

Pca,

LNCaP

1–5 μg/ml

in-vitro,

Pca,

22Rv1

in-vitro,

Pca,

PC3

in-vitro,

Nor,

PWR-1E

NOX↓, selectivity↑,

2523-

H2,

Prospects of molecular hydrogen in cancer prevention and treatment

Review,

Var,

ROS↓, TumCP↓, TumMeta↓, AntiTum↑, GutMicro↑, Inflam↓, OS↑, radioP↑, selectivity↑, SOD↑, IL1β↑, IL8↑, TNF-α↑, neuroP↑,

2516-

H2,

Hydrogen Gas in Cancer Treatment

Review,

Var,

*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,

2512-

H2,

Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

in-vivo,

asthmatic,

selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,

2509-

H2,

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway

in-vitro,

Endo,

AN3CA

in-vivo,

Endo,

endometrial tumors in a xenograft mouse model.

selectivity↑, mt-ROS↑, ROS↑, TumW↓, GSDMD↑, Pyro↑, Dose↝, eff↓, TumVol↓,

2526-

H2,

Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro

in-vitro,

ESCC,

KYSE-510

 we investigated solidified hydrogen-occluding-silica (H2-silica) that can release molecular hydrogen into cell culture medium

*ROS↓, selectivity↑, ROS↓,

2528-

H2,

Local generation of hydrogen for enhanced photothermal therapy

in-vitro,

Var,

eff↑, ROS↓, selectivity↑, ROS↑, other↝, ROS↑,

1638-

HCAs,

Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications

Review,

Nor,

*BioAv↓, Inflam↓, COX2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27↑, P53↑, VEGF↓, MAPK↓,

2073-

HNK,

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

in-vitro,

OS,

U2OS

21.5 μM

in-vivo,

NA,

40 mg/kg

TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,

2875-

HNK,

Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

in-vitro,

Lung,

A549

20, 40 and 60 µM

in-vitro,

Lung,

H1299

in-vitro,

Lung,

H460

in-vitro,

SCC,

H226

HDAC↓, tumCV↓, TumCCA↑, cycD1/CCND1↓, ac‑H3↑, ac‑H4↑, selectivity↑, CDK2↓, CDK4↓,

2879-

HNK,

Honokiol Inhibits Lung Tumorigenesis through Inhibition of Mitochondrial Function

in-vitro,

Lung,

H226

in-vivo,

NA,

mouse

tumCV↓, selectivity↑, TumCP↓, TumCCA↑, Apoptosis↑, mt-ROS↑, Casp3↑, Casp7↑, OCR↓, Cyt‑c↑, ATP↓, mitResp↓, AMP↑, AMPK↑,

2865-

HNK,

Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma

in-vitro,

MB,

DAOY

vitro+vivo,

NA,

BioAv↓, BioAv↓, TumCP↓, selectivity↑, P53↑, P21↑, CDK4↓, cycD1/CCND1↓, mtDam↑, ROS↑, eff↓, Casp3↑, BAX↑, LC3II↑, Beclin-1↑, ATG7↑, p62↑, eff↑, ChemoSen↑, *toxicity↓,

2864-

HNK,

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Review,

Var,

TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,

2891-

HNK,

Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs

Review,

Var,

AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,

2892-

HNK,

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells

in-vitro,

Lung,

A549

 30.42

in-vitro,

Lung,

H460

50.58

in-vitro,

Lung,

H385

59.38 ± 6.75 μM

in-vitro,

Nor,

BEAS-2B

TumCCA↑, Apoptosis↑, SIRT3↑, Hif1a↓, selectivity↑, p‑mTOR↓, p70S6↓,

2895-

HNK,

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

in-vitro,

Lung,

PC9

 0.26 μM

eff↑, TumCP↓, mt-ROS↑, Prx3↑, mt-STAT3↓, *toxicity∅, selectivity↑, ChemoSen↑,

4637-

HT,

Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells

in-vitro,

Nor,

RWPE-1

52.20 ± 4.19

in-vitro,

Pca,

LNCaP

41.17 ± 2.79

in-vitro,

Pca,

22Rv1

9.32 ± 0.50

in-vitro,

Pca,

PC3

28.88 ± 2.25

selectivity↑, TumCMig↓, p‑Akt↓, ROS↑, CSCs↓, CD44↓, TumCP↓,

4638-

HT,

Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation

in-vitro,

CRC,

DLD1

NA,

selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,

4639-

HT,

Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

C4-2B

TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,

4640-

HT,

The anti-cancer potential of hydroxytyrosol

Review,

Var,

selectivity↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, MPT↑, Fas↑, PI3K↓, Akt↓, mTOR↓, Mcl-1↓, survivin↓, STAT3↓, EMT↓, TumCI↓, angioG↓, E-cadherin↑, N-cadherin↓, Snail↓, Twist↓, MMPs↓, MMP2↓, MMP9↓, VEGF↓, VEGFR2↓, Hif1a↓, CSCs↓, CD44↓, Wnt↓, β-catenin/ZEB1↓,

1917-

JG,

Inhibition of human leukemia cells growth by juglone is mediated via autophagy induction, endogenous ROS production, and inhibition of cell migration and invasion

in-vitro,

AML,

HL-60

0-80uM

selectivity↑, LC3I↑, LC3II↑, Beclin-1↑, ROS↑, tumCV↓, Dose↝, TumAuto↑,

2925-

LT,

Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

HEK293

in-vitro,

BC,

MCF-7

HSP90↓, p‑STAT3↓, Apoptosis↑, selectivity↑,

2904-

LT,

Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons

in-vitro,

Park,

SK-N-SH

in-vitro,

AD,

*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,

1715-

Lyco,

Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence

Review,

Var,

antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, eff↑,

4783-

Lyco,

Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells

in-vitro,

GC,

AGS

in-vitro,

GC,

SGC-7901

in-vitro,

Nor,

GES-1

TumCG↓, TumCCA↑, Apoptosis↑, MMP↓, selectivity↑, cycE1↓, TP53↑, *antiOx↑,

4791-

Lyco,

Investigating into anti-cancer potential of lycopene: Molecular targets

Review,

Var,

*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,

4796-

Lyco,

The Anti-proliferation Effects of Lycopene on Breast Cancer Cells

in-vitro,

BC,

MCF-7

 0,2,4,6,8 and 10 μM lycopene media solution prepared from 2 mM stock solution of pure crystalline lycopene in tetrahydrofuran.

in-vitro,

Nor,

MCF10

TumCG↓, selectivity↑, *BioAv↑, *antiOx↑, *ROS↓, Risk↓, *cardioP↑,

2540-

M-Blu,

Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Review,

Var,

Review,

AD,

*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,

5252-

MAG,

Insights on the Multifunctional Activities of Magnolol

Review,

Var,

BioAv↓, *Inflam↓, *Bacteria↓, *antiOx↑, *neuroP↑, *cardioP↑, CYP1A1↓, *PPARγ↑, *NF-kB↓, *COX2↓, *iNOS↓, *ROS↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, P21↑, TumCG↓, TumCMig↓, TumCI↓, Ki-67↓, PCNA↓, MMP2↓, MMP9↓, MMP7↓, DNAdam↑, MMP↓, TumCP↓, selectivity↑, PI3K↓, Akt↓, H2O2↓, Hif1a↓, *BDNF↑, *NRF2↑, *AChE↑,

4534-

MAG,

Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells

in-vitro,

Liver,

HepG2

in-vitro,

CRC,

COLO205

AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

4516-

MAG,

Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models

in-vivo,

NSCLC,

selectivity↑, Apoptosis↑, TumCCA↑, Casp3↑, cycD1/CCND1↓, CDK4↓, VEGF↓, FOXP3↓, IDO1↓,

4536-

MAG,

Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis

in-vitro,

Liver,

HepG2

in-vivo,

CRC,

COLO205

implanted subcutaneously in nude mice

AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,

1898-

MeJa,

Methyl jasmonate and its potential in cancer therapy

Review,

Var,

ROS↑, selectivity↑, toxicity↝,

1785-

MEL,

Antitumoral melatonin-loaded nanostructured lipid carriers

in-vitro,

Var,

selectivity↑, TumCD↑,

1781-

MEL,

Melatonin in patients with cancer receiving chemotherapy: a randomized, double-blind, placebo-controlled trial

Trial,

Lung,

QoL↑, OS∅, selectivity↑,

1778-

MEL,

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

Review,

Var,

Review,

AD,

*ROS↓, *antiOx↓, ROS↑, selectivity↑, Dose↑, *mitResp↑, *ATP↑, *ROS↓, eff↑, ROS↑, Dose↑, *toxicity∅, ROS↑, eff↓, ROS↝, Dose↑, other↑,

1777-

MEL,

Melatonin as an antioxidant: under promises but over delivers

Review,

NA,

*ROS↓, *Fenton↓, *antiOx↑, *toxicity∅, *GPx↑, *GSR↑, *GSH↑, *NO↓, *Iron↓, *Copper↓, *IL1β↓, *iNOS↓, *Casp3↓, *BBB↑, *RenoP↑, chemoP↑, *Ca+2↝, eff↑, *PKCδ?, ChemoSen↑, eff↑, Akt↓, DR5↑, selectivity↑, ROS↑, eff↑,

2244-

MF,

Little strokes fell big oaks: The use of weak magnetic fields and reactive oxygen species to fight cancer

Review,

Var,

RPM↑, Glycolysis∅, ROS↑, ChemoSen↑, RadioS↑, selectivity↑,

2237-

MF,

The Effect of Pulsed Electromagnetic Field Stimulation of Live Cells on Intracellular Ca2+ Dynamics Changes Notably Involving Ion Channels

in-vitro,

AML,

KG-1

40 mins

 10 Hz [DC: 30%, intensity:26.2 mT], 30 Hz [DC: 30%, intensity:20.3 mT], and 50 Hz [DC: 30%, 15 mT].

in-vitro,

Nor,

HUVECs

Ca+2↑, selectivity↑, *Inflam↓, *TNF-α↓, *NF-kB↓, *Ca+2↓,

2261-

MF,

Tumor-specific inhibition with magnetic field

in-vitro,

Nor,

GP-293

5 mT, 2h/day, 3 days

in-vitro,

Liver,

HepG2

in-vitro,

Lung,

A549

ROS↑, Ca+2↓, Apoptosis↑, *selectivity↑, TumCG↓, *i-Ca+2↓, i-Ca+2↑,

2260-

MF,

Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming

in-vitro,

GBM,

U87MG

18 mT at the center

in-vitro,

GBM,

LN229

in-vivo,

NA,

AMF for 30 min daily, for a total of five sessions.

mice

TumCP↓, TumCG↓, OS↑, ROS↑, SOD2↑, eff↓, ECAR↓, OCR↑, selectivity↑, *toxicity∅, TumVol↓, PGC-1α↑, OXPHOS↑, Glycolysis↓, PKM2↓,

526-

MF,

Inhibition of Cancer Cell Growth by Exposure to a Specific Time-Varying Electromagnetic Field Involves T-Type Calcium Channels

in-vitro,

BC,

MDA-MB-231

Thomas-EMF is a low-intensity, frequency-modulated (25-6 Hz) EMF pattern.

Thomas-EMF used in our experiments is a complex time-modulated pattern (25–6 HZ)

in-vitro,

BC,

MCF-7

in-vitro,

Pca,

HeLa

vitro+vivo,

Melanoma,

B16-BL6

in-vitro,

Nor,

HEK293

TumCG↓, Ca+2↑, selectivity↑, *Ca+2∅, ROS↑, HSP70/HSPA5↑, AntiCan↑,

532-

MF,

A 50 Hz magnetic field influences the viability of breast cancer cells 96 h after exposure

in-vitro,

BC,

MDA-MB-231

0.1 mT and 1.0 mT, 50Hz, 96h

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

TumCP↓, MMP↓, ROS↑, eff↝, selectivity↑,

534-

MF,

Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer

in-vitro,

BC,

MCF-7

0.5,1mT 8-39Hz

square wave

in-vitro,

BC,

MDA-MB-231

in-vivo,

Nor,

MCF10

Ca+2↑, Apoptosis↑, eff↝, eff↑, selectivity↑, eff↝, eff↝,

496-

MF,

Low-Frequency Magnetic Fields (LF-MFs) Inhibit Proliferation by Triggering Apoptosis and Altering Cell Cycle Distribution in Breast Cancer Cells

in-vitro,

BC,

MCF-7

1mT, 200Hz, 24h

200 Hz reached the optimum inhibition effect

in-vitro,

BC,

ZR-75-1

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

ROS↑, PI3K↓, Akt↓, GSK‐3β↑, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, CycB/CCNB1↓, TumCCA↑, p‑Akt↓, TumCP↓, selectivity↑, eff↓,

501-

MF,

Low Intensity and Frequency Pulsed Electromagnetic Fields Selectively Impair Breast Cancer Cell Viability

in-vitro,

BC,

MCF-7

2-5mT, 10-50Hz, 30-90min/d

harmless to non-malignant cell types

in-vitro,

Nor,

MCF10

Apoptosis↑, *toxicity↓, ChemoSen↑, chemoP↑, selectivity↑, DNAdam↑,

507-

MF,

Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism

in-vitro,

Liver,

HepG2

5 mT and 20 Hz

adherence inhibition rate for Hepg2 and A549 estimated at 18% and 30% respectively

in-vitro,

Lung,

A549

in-vitro,

Nor,

GP-293

MMP↓, TumCG↓, ROS↑, *Ca+2↓, Ca+2↑, selectivity↑, i-pH↑,

512-

MF,

Pulsed Electromagnetic Fields (PEMFs) Trigger Cell Death and Senescence in Cancer Cells

in-vitro,

BC,

MCF-7

11mT, 8Hz, square wave, 2x/d 30mins, 5 d

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

FF95

TumCP↓, *toxicity↓, ChemoSen↑, RadioS↑, selectivity↑, Ca+2↑,

4092-

MF,

Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology

Review,

Var,

Apoptosis↑, selectivity↑, ROS↑, Catalase↓, TumVol↓, angioG↓,

3480-

MF,

Cellular and Molecular Effects of Magnetic Fields

Review,

NA,

ROS↑, *Ca+2↑, *Inflam↓, *Akt↓, *mTOR↓, selectivity↑, *memory↑, *MMPs↑, *VEGF↑, *FGF↑, *PDGF↑, *TNF-α↑, *HGF/c-Met↑, *IL1↑,

3478-

MF,

One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study

Trial,

BC,

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

C2C12

TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,

3465-

MF,

Magnetic fields and angiogenesis

Review,

Var,

angioG↓, *angioG↑, selectivity↑, Ca+2↝, ROS↝,

4425-

MF,

doxoR,

Brief Magnetic Field Exposure Stimulates Doxorubicin Uptake into Breast Cancer Cells in Association with TRPC1 Expression: A Precision Oncology Methodology to Enhance Chemotherapeutic Outcome

in-vitro,

BC,

4T1

in-vitro,

BC,

MCF-7

ChemoSen↑, TRPC1↑, Dose↓, selectivity↑,

4354-

MF,

doxoR,

Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach

in-vivo,

BC,

MDA-MB-231

3mT, PEMFs stimulation for 1 h weekly for 5 weeks

NSG mice were purchased from The Jackson’s Laboratory and used at 8-10 weeks of age.

in-vivo,

BC,

MCF-7

selectivity↑, Apoptosis↑, TumCI↓, tumCV↓, TumVol↓, eff↓, eff↑, ROS↑, Ca+2↑, TumCMig↓,

5241-

MF,

A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment

Review,

Var,

other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,

2259-

MFrot,

MF,

Method and apparatus for oncomagnetic treatment

in-vitro,

GBM,

Oncomagnetic patent

MMP↓, Bcl-2↓, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, DNAdam↑, ROS↑, lactateProd↑, Apoptosis↑, MPT↑, *selectivity↑, eff↑, MMP↓, selectivity↑, TCA?, H2O2↑, eff↑, *antiOx↑, H2O2↑, eff↓, GSH/GSSG↓, *toxicity∅, OS↑,

2258-

MFrot,

MF,

EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE

in-vitro,

GBM,

GBM

in-vitro,

Nor,

SVGp12

TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,

186-

MFrot,

MF,

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields

in-vitro,

GBM,

GBM

 new device that generates oscillating magnetic fields (OMF) by rapid rotation of strong permanent magnets in specially designed patterns of frequency and timing

in-vitro,

Lung,

mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓, H2O2↑, eff↓, GSH↑, MMP↓,

187-

MFrot,

MF,

Method for noninvasive whole-body stimulation with spinning oscillating magnetic fields and its safety in mice

in-vivo,

GBM,

healthy mice

selectivity↑, ROS↑, *ROS∅, *toxicity∅, ETC↓, TumVol↓, Dose↝,

184-

MFrot,

MF,

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

in-vitro,

GBM,

GBM

 80mT pulsed

ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,

205-

MFrot,

MF,

Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis

vitro+vivo,

BC,

MDA-MB-231

 0.1-T and 0.4-T (~4.2 Hz)

 mouse

OS↑, F-actin↓, TumCI↓, TumCMig↓, Rho↓, selectivity↑, TumMeta↓,

198-

MFrot,

MF,

Biological effects of rotating magnetic field: A review from 1969 to 2021

Review,

Var,

AntiCan↑, breath↑, Pain↓, Appetite↑, Strength↑, BowelM↑, TumMeta↓, TumCCA↑, ETC↓, MMP↓, TumCD↑, selectivity↑, ROS↑, Casp3↑, TumCG↓, TumCCA↑, ChrMod↑, TumMeta↓, Imm↑, DCells↑, Akt↓, OS⇅, toxicity↓, QoL↑, hepatoP↑, Pain↓, Weight↑, Strength↑, Sleep↑, IL6↓, CD4+↑, CD8+↑, Ca+2↑, radioP↑, chemoP↑, *BMD↑, *AntiAge↑, *AMPK↑, *P21↓, *P53↓, *mTOR↓, *OS↑, *β-Endo↑, *5HT↓,

4566-

MFrot,

On the mitochondrial aspect of reactive oxygen species action in external magnetic fields

Study,

Var,

ROS↑, ETC↓, selectivity↑,

1891-

MGO,

Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma

in-vitro,

SCC,

NADH↓, MMP↓, Cyt‑c↑, selectivity↑, Apoptosis↑, ROS↑, ATP↓,

4976-

Nimb,

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

vitro+vivo,

PC,

ROS↑, Apoptosis↑, TumAuto↑, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Dose↓, selectivity↑, Akt↓, eff↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓,

4643-

OLE,

HT,

Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

Review,

Var,

TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,

1812-

Oxy,

Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer

in-vitro,

Lung,

A549

in-vivo,

Lung,

mouse

in-vitro,

NA,

BEAS-2B

TumCG↓, CD31↑, P53↓, Dose∅, other↑, Apoptosis↑, Hif1a↑, selectivity↑,

2061-

PB,

Chemo,

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells

in-vitro,

PC,

PANC1

in-vitro,

PC,

COLO357

in-vitro,

PC,

Bxpc-3

HDAC↓, Apoptosis↑, eff↑, selectivity↑, TumCCA↑, eff↑, selectivity↑,

2037-

PB,

Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria

in-vitro,

GBM,

in-vivo,

GBM,

rats bearing intracranial gliomas

AntiTum↑, *toxicity↓, selectivity↑, TumCG↓,

2046-

PB,

Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment

in-vitro,

BC,

MCF-7

0.1–20 mM) for 24, 48, 72 h

in-vitro,

BC,

MDA-MB-468

in-vitro,

Nor,

MCF10

Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,

1674-

PBG,

SDT,

HPT,

Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells

in-vitro,

PC,

PANC1

in-vitro,

Nor,

H6c7

tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,

1681-

PBG,

Propolis: Its Role and Efficacy in Human Health and Diseases

Review,

Nor,

*Inflam↓, *AntiCan↑, *antiOx↑, *hyperG↓, *BG↓, *HbA1c↓, *NF-kB↓, *ROS↓, *TGF-β↑, *selectivity↑,

1684-

PBG,

Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

in-vitro,

BC,

MCF-7

25, 50, 100, and 200 μg/mL

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

HUVECs

Apoptosis?, ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑,

1685-

PBG,

Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

in-vitro,

BC,

MCF-7

25, 50, 100, and 200 μg/mL

ANXA7↑, ROS↑, NF-kB↓, MMP↓, selectivity↑, Dose⇅, ROS⇅,

1670-

PBG,

Lung response to propolis treatment during experimentally induced lung adenocarcinoma

in-vivo,

Lung,

rats

GSH↑, SOD↑, MDA↓, selectivity↑, Inflam↓, TumW↓,

1663-

PBG,

Propolis and Their Active Constituents for Chronic Diseases

Review,

Var,

NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,

1666-

PBG,

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Review,

Var,

ChemoSen↑, TumCCA↑, TumCP↓, Apoptosis↑, antiOx↓, ROS↑, COX2↑, ER(estro)↓, cycA1/CCNA1↓, CycB/CCNB1↓, CDK2↓, P21↑, p27↑, hTERT/TERT↓, HDAC↓, ROS⇅, Dose?, ROS↓, ROS↑, DNAdam↑, ChemoSen↑, LOX1↓, lipid-P↓, NO↑, Igs↑, NK cell↑, MMPs↓, VEGF↓, Hif1a↓, GLUT1↓, HK2↓, selectivity↑, RadioS↑, GlucoseCon↓, lactateProd↓, eff↓, *BioAv↓,

1668-

PBG,

Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms

Review,

Var,

antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,

4946-

PEITC,

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

PC3

Apoptosis↑, TumAuto↑, ROS↑, OXPHOS↓, ATP↓, selectivity↑, ETC↓, eff↓, eff↓, BAX↑,

4949-

PEITC,

Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells

in-vitro,

Cerv,

HeLa

ROS↑, selectivity↑, CSCs↓, Sp1/3/4↓, P-gp↓, ALDH↓, GSH↓, TumCP↓, Apoptosis↑,

4951-

PEITC,

ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis

in-vitro,

Ovarian,

PA1

5 μM

in-vitro,

Ovarian,

SKOV3

ROS↑, TumCP↓, GSH↓, selectivity↑, UPR↑, CHOP↑, ER Stress↑, GRP78/BiP↑, PERK↑, ATF6↑, eff↓, TumCG↓, Apoptosis↑, toxicity↓,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,

4963-

PEITC,

Sensory Acceptable Equivalent Doses of β - Phenylethyl isothiocyanate (PEITC) Induce Cell Cycle Arrest and Retard Growth of p53 Mutated Oral Cancer In Vitro and In Vivo

vitro+vivo,

Oral,

CAL27

5 and 10 mg/kg PEITC, equivalent to human organoleptic acceptable doses

vitro+vivo,

Oral,

FaDu

vitro+vivo,

Oral,

SCC4

vitro+vivo,

Oral,

SCC9

Dose↝, selectivity↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4922-

PEITC,

Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms

Review,

Var,

Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,

4924-

PEITC,

Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial

Trial,

Oral,

 consumed 200 g of Nutri-Jelly with and without 20 mg of PEITC

QoL↑, P53↑, OS↑, Cyt‑c↝, other↝, ROS↑, selectivity↑, P21↑, TumCCA↑, Dose↝, BioAv↑, Weight↑, chemoP↑,

4928-

PEITC,

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

vitro+vivo,

Colon,

SW-620

 6 weeks duration either in the presence 2.5 μM PEITC

nude mice,

Risk↓, HDAC↓, TumW↓, TumCG↓, AP-1↓, cAMP↓, NF-kB↓, BMI1↓, SUZ12↓, EZH2↓, selectivity↑,

4941-

PEITC,

PEITC: A resounding molecule averts metastasis in breast cancer cells in vitro by regulating PKCδ/Aurora A interplay

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

PKCδ↑, Apoptosis↓, selectivity↑, tumCV↓, p‑NRF2↑, cl‑PARP1↑, TumCMig↓, ROS↓, Hif1a↓,

5183-

PEITC,

Cisplatin,

Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

HaCaT

DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,

5220-

PG,

TMZ,

Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway

in-vitro,

GBM,

U87MG

TumCMig↓, MMP2↓, MMP9↓, NF-kB↓, ROS↑, selectivity↑,

1947-

PL,

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

in-vitro,

GC,

SGC-7901

in-vitro,

GC,

TrxR1↓, ROS↑, ER Stress↑, mtDam↑, selectivity↑, NO↑, TumCCA↑, mt-ROS↑, Casp9↑, Bcl-2↓, Bcl-xL↓, cl‑PARP↑, eff↓, lipid-P↑,

1948-

PL,

born,

Natural borneol serves as an adjuvant agent to promote the cellular uptake of piperlongumine for improving its antiglioma efficacy

in-vitro,

GBM,

selectivity↑, ROS↑, BioAv↓, BioAv↑, Apoptosis↑, TumCCA↑, eff↑,

1949-

PL,

Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor

in-vitro,

CRC,

HCT116

in-vitro,

Cerv,

HeLa

TrxR↓, selectivity↑, ROS↑, IDO1↓,

1950-

PL,

Increased Expression of FosB through Reactive Oxygen Species Accumulation Functions as Pro-Apoptotic Protein in Piperlongumine Treated MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

in-vitro,

Lung,

A549

selectivity↑, ROS↑, SETBP1↓, cl‑Casp9↑, eff↓, FOSB↑,

1953-

PL,

Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation

in-vitro,

Lung,

A549

in-vitro,

Nor,

WI38

ROS↑, selectivity↑, TrxR↓, TumCCA↑, GSH?, H2O2↑,

1944-

PL,

Piperlongumine, a Novel TrxR1 Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cells by ROS-Mediated ER Stress

in-vitro,

HCC,

HUH7

0.625, 2.5, 5, 10, 15, 20, 30, 40, and 50 µM

in-vitro,

HCC,

HepG2

ER Stress↑, TrxR1↓, ROS↑, eff↓, Bcl-2↓, proCasp3↓, BAX↓, cl‑Casp3↑, TumCCA↑, p‑PERK↑, ATF4↑, TumCG↓, lipid-P↑, selectivity↑,

1943-

PL,

Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells

in-vitro,

GBM,

0-10 μM

in-vivo,

NA,

mice

selectivity↑, ROS↑, selectivity↑, Prx4↓, *Prx4∅, ER Stress↑, CHOP↑, UPR↑,

1941-

PL,

Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer

in-vitro,

HNSCC,

selectivity↑, eff↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,

1939-

PL,

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

in-vitro,

HCC,

HepG2

5-20 μM

in-vitro,

HCC,

HUH7

in-vivo,

NA,

(1.5 mg/kg

mice

TumCMig↓, TumCI↓, ER Stress↑, selectivity↑, tumCV↓, ROS↑, GSH↓, eff↓, Ca+2↑, MAPK↑, CHOP↑, Dose↝,

2973-

PL,

The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

4T1

MMP2↓, MMP9↓, IL6↓, E-cadherin↑, ROS↑, EMT↓, Zeb1↓, Slug↓, TumMeta↓, selectivity↑, MMP2↓, GSH↓,

3000-

PL,

Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

in-vitro,

Nor,

HUVECs

in-vitro,

Laryn,

HEp2

Inflam↓, AntiTum↑, *α-tubulin↓, selectivity↑, HIF2a↓, MCP1↓,

2941-

PL,

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

in-vivo,

BC,

MDA-MB-231

mice

in-vitro,

OS,

U2OS

in-vitro,

BC,

MDA-MB-453

ROS↑, Apoptosis↑, selectivity↑, *ROS∅, GSH↓, GSSG↑, H2O2↑, NO↑, Half-Life?,

2944-

PL,

Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells

in-vitro,

Thyroid,

IHH4

 2 and 3 μM

in-vitro,

Thyroid,

8505C

in-vivo,

NA,

10 mg/kg

Nude mice

ROS↑, selectivity↑, tumCV↓, TumCCA↑, Apoptosis↑, ERK↑, Akt↓, mTOR↓, neuroP↑, Bcl-2↓, Casp3↑, PARP↑, JNK↑, *toxicity↓, eff↓, TumW↓,

2946-

PL,

Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent

Review,

Var,

ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp↓, MDR1↓, MRP1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,

2949-

PL,

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

in-vitro,

GBM,

LN229

5, 10 and 20 uM

in-vitro,

GBM,

U87MG

selectivity↑, ROS↑, JNK↑, p38↑, GSH↓, eff↓,

2955-

PL,

Heme Oxygenase-1 Determines the Differential Response of Breast Cancer and Normal Cells to Piperlongumine

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

ROS?, *ROS∅, other⇅, HO-1↑, *HO-1↑, NRF2↑, Keap1↓, cl‑PARP↑, selectivity↑, GSH↓, GSSG↑,

2954-

PL,

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy

Review,

Var,

NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,

2006-

PLB,

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway

in-vitro,

OS,

MG63

in-vitro,

Nor,

hFOB1.19

tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,

2005-

PLB,

Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)

in-vivo,

Nor,

EL4

mouse

in-vitro,

AML,

Jurkat

JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,

4969-

PSO,

The Coumarin Psoralidin Enhances Anticancer Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

in-vitro,

Cerv,

HeLa

AntiCan↑, chemoPv↑, TRAIL↑, selectivity↑, toxicity↓, MMP↓, Apoptosis↑,

5157-

PTL,

An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells

vitro+vivo,

AML,

Canine studies

CSCs↓, selectivity↑, BioAv↓, BioAv↑, ROS↑, NF-kB↓, P53↑,

5156-

PTL,

Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells

in-vitro,

AML,

NADPH↑, PPP↑, NRF2↑, ROS↑, CSCs↓, selectivity↑, other↝,

1987-

PTL,

Rad,

A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells

in-vitro,

Pca,

PC3

in-vitro,

Nor,

PrEC

selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,

1994-

PTL,

Parthenolide Inhibits Tumor Cell Growth and Metastasis in Melanoma A2058 Cells

in-vitro,

Melanoma,

A2058

20uM

in-vitro,

Nor,

L929

27uM

tumCV↓, selectivity?, ROS?, BAX↑, TumCCA?, MMP2↓, MMP9↓, TumCMig↓, eff↑,

2409-

PTS,

Pterostilbene Induces Pyroptosis in Breast Cancer Cells through Pyruvate Kinase 2/Caspase-8/Gasdermin C Signaling Pathway

in-vitro,

BC,

EMT6

 0, 20, 40, 60, and 80 µM of PTE for 24, 48, and 72 h

in-vitro,

BC,

4T1

in-vitro,

Nor,

HC11

Pyro↑, Glycolysis↓, *toxicity∅, selectivity↑, GSDMC↑, PKM2↓, PKM1↑, GlucoseCon↓, lactateProd↓, ATP↓, TumCG↓,

3344-

QC,

Quercetin induced ROS production triggers mitochondrial cell death of human embryonic stem cells

in-vitro,

Nor,

hESC

mt-ROS↑, selectivity↑, P53↑, ROS⇅,

3380-

QC,

Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases

Review,

Var,

Review,

Park,

Review,

AD,

JAK↓, STAT↓, Inflam↓, NO↓, COX2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,

3353-

QC,

Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells

in-vitro,

Oral,

KON

 0, 1.5625, 3.125, 6.25, 12.5, 25, 50, 100, and 400 µg/mL

50ug/L @ 72h

in-vitro,

Nor,

MRC-5

tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,

3343-

QC,

Quercetin, a Flavonoid with Great Pharmacological Capacity

Review,

Var,

Review,

AD,

Review,

Arthritis,

*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,

66-

QC,

Emerging impact of quercetin in the treatment of prostate cancer

Review,

Pca,

CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt/(β-catenin)↓, PSA↓, VEGF↓, PARP↑, Casp3↑, Casp9↑, DR5↑, ROS⇅, Shh↓, P53↑, P21↑, EGFR↓, TumCCA↑, ROS↑, miR-21↓, TumCP↓, selectivity↑, PDGF↓, EGF↓, TNF-α↓, VEGFR2↓, mTOR↓, cMyc↓, MMPs↓, GRP78/BiP↑, CHOP↑,

71-

QC,

Role of Bax in quercetin-induced apoptosis in human prostate cancer cells

in-vitro,

Pca,

LNCaP

 10, 30, 50 100 uM

in-vitro,

Pca,

PrEC

in-vitro,

Pca,

YPEN-1

in-vitro,

Pca,

HCT116

Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓, Cyt‑c↑, selectivity↑,

73-

QC,

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90

in-vitro,

Pca,

LNCaP

5, 10, 25, 50, 100 uM

 Normal prostate epithelial cells

in-vitro,

Pca,

DU145

in-vitro,

Pca,

PC3

HSP90↓, Casp3↑, Casp9↑, TumCG↓, TumCD↑, selectivity↑, toxicity↓,

2303-

QC,

doxoR,

Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells

in-vitro,

BC,

4T1

100uM

51.42 uM

in-vivo,

NA,

quercetin 100 mg/kg day or DOX 5 mg/kg

mice

cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,

2991-

RES,

Chemo,

Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells

in-vitro,

Melanoma,

MSTO-211H

in-vitro,

Nor,

MeT5A

eff↑, selectivity↑, Sp1/3/4↓,

1744-

RosA,

Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity

Review,

Var,

chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,

3011-

RosA,

Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition

in-vitro,

GBM,

SH-SY5Y

MARK4 activity (IC50 = 6.204 µM)

in-vitro,

Lung,

A549

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

MCF10

MARK4↓, p‑tau↓, selectivity↑, *toxicity∅,

3008-

RosA,

Rosmarinic acid decreases viability, inhibits migration and modulates expression of apoptosis-related CASP8/CASP3/NLRP3 genes in human metastatic melanoma cells

in-vitro,

Melanoma,

SK-MEL-28

tumCV↓, TumCMig↓, ROS↓, Casp3↑, selectivity↑, Casp8↑, NLRP3↓,

3033-

RosA,

Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth

in-vitro,

Pca,

22Rv1

0 and 50 µg/ml of rosemary extract for 24 hrs.

13.3 µg/ml

in-vitro,

Pca,

LNCaP

27 µg/ml

vitro+vivo,

NA,

Athymic nude mice

ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP↑, PERK↓, GRP78/BiP↑, PSA↓,

4899-

Sal,

Anticancer activity of salinomycin quaternary phosphonium salts

in-vitro,

Var,

eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,

4903-

Sal,

Salinomycin: A new paradigm in cancer therapy

Review,

Var,

TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,

5004-

Sal,

Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,

5003-

Sal,

Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review

Review,

Var,

CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,

4996-

Sal,

The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

CSCs↓, selectivity↑, Wnt↓, ERStress↑, Ca+2↓, UPR↑, CHOP↑, β-catenin/ZEB1↓, CD44↓, CD24↓, PKCδ↑,

4905-

Sal,

Salinomycin as a drug for targeting human cancer stem cells

Review,

Var,

CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,

4910-

Sal,

A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent

Apoptosis↑, CSCs↓, ChemoSen↑, RadioS↑, selectivity↑, Wnt↓, toxicity⇅,

5122-

Sal,

Identification of selective inhibitors of cancer stem cells by high-throughput screening

in-vivo,

BC,

SUM159

NA,

4T1

CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,

5121-

Sal,

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

in-vitro,

BC,

CSCs↓, Wnt↓, selectivity↑,

5041-

SAS,

Cisplatin,

Xc− inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

in-vitro,

CRC,

xCT↓, Inflam↓, Apoptosis↓, GSH↓, ROS↑, TumCG↓, selectivity↑, eff↑, eff↓,

5038-

SAS,

Rad,

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

in-vivo,

Melanoma,

B16-F10

xCT↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,

2549-

SDT,

Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation

Review,

Var,

sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp↓, ER Stress↑, other↑,

4615-

Se,

Rad,

Selenium as an adjuvant for modification of radiation response

Review,

Nor,

*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,

4484-

Se,

Chit,

PEG,

Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells

in-vitro,

Melanoma,

U266

tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

4488-

Se,

Chit,

PEG,

Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats

in-vivo,

Liver,

HepG2

 size ranging from 390 to 450 nm

diethylnitrosamine (DEN)-induced liver cancer in rats

in-vivo,

Nor,

HL7702

tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,

4715-

Se,

The Interaction of Selenium with Chemotherapy and Radiation on Normal and Malignant Human Mononuclear Blood Cells

chemoP↑, radioP↑, selectivity↑, ChemoSen↑, GSH↓, *GSH↑, *DNAdam↓, DNAdam↑, eff↑,

4734-

SeNPs,

CPT-11,

Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles

in-vitro,

CRC,

HCT8

in-vivo,

NA,

chemoP↑, ChemoSen↑, P53↑, Apoptosis↑, TumCG↓, Casp↑, Dose↝, NRF2↓, selectivity↑, *NRF2↑,

4608-

SeNPs,

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Review,

Var,

NA,

AD,

*toxicity↝, *toxicity↓, *other↝, ROS↑, *Dose↝, *selenoP↑, AntiCan↑, AntiTum↑, *Bacteria↓, *radioP↑, *BioAv↑, *Inflam↓, *Imm↑, ChemoSen↑, *AntiAg↑, selectivity↑, eff↑, other↝, *eff↑, *Aβ↓, *eff↑,

4603-

SeNPs,

Therapeutic applications of selenium nanoparticles

Review,

Var,

AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, eff↑, *eff↑,

4480-

SeNPs,

Chit,

Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway

in-vitro,

Lung,

A549

 55.285 and 30.9 nm, for SeNPs and Se-chitosan NPs, respectively.

Chito-NPs of 24.09 µg/mL, whereas for SeNPs it was 18.56 µg/mL

in-vitro,

Nor,

HK-2

selectivity↑, *toxicity↓, ROS↑, mtDam↑, Apoptosis↑, LDH↑,

4501-

SeNPs,

Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell Lines

in-vitro,

GBM,

A172

10ug/mL

in-vitro,

Colon,

Caco-2

in-vitro,

Pca,

DU145

3ug/mL

in-vitro,

BC,

MCF-7

10ug/mL

in-vitro,

Nor,

L929

*BioAv↑, selectivity↑, AntiCan↑, Apoptosis↑, CHOP↑, GADD34↑, BIM↑, PUMA↑, Ca+2↝,

4469-

SeNPs,

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Review,

Var,

antiOx↑, selectivity↑, eff↑, AntiCan↑, Apoptosis↑, ROS↑, MMP↓, Casp3↑, Casp9↑, AntiTum↑, TumCG↓, TumMeta↓, angioG↓, Cyt‑c↑, DNAdam↑, RadioS↑, BBB↑, *toxicity↓, ChemoSen↑,

4471-

SeNPs,

Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis

in-vitro,

Liver,

HepG2

stable SeNPs were prepared with an average size of 113 nm

eff↑, ROS↑, MMP↓, Casp9↑, Bcl-2↓, selectivity↑, Apoptosis↑,

4472-

SeNPs,

Therapeutic potential of selenium nanoparticles

Review,

Var,

*ROS↓, *BioAv↑, *antiOx↑, toxicity↓, eff↑, *other↝, EPR↑, selectivity↑, eff↑, RadioS↑, eff↑, *Bacteria↓,

4473-

SeNPs,

Anti-cancerous effect and biological evaluation of green synthesized Selenium nanoparticles on MCF-7 breast cancer and HUVEC cell lines

in-vitro,

BC,

MCF-7

65 nm and 34 nm

in-vitro,

Nor,

HUVECs

AntiCan↑, selectivity↓, *Bacteria↓, *antiOx↑, *toxicity↓, ROS↑, tumCV↓,

4449-

SeNPs,

PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction

in-vitro,

Liver,

HepG2

PEG-SeNPs had Se cores about 5 nm in diameter, and the coated PEG gave them coronas and hydrodynamic diameters of about 28.7 nm

MMP↓, selectivity↑, Apoptosis↑, ROS↑,

4448-

SeNPs,

Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies

Review,

Nor,

*toxicity↓, *toxicity↓, selectivity↑, *antiOx↑, *cognitive↑, *other↝, TumCCA↑,

4453-

SeNPs,

Selenium Nanoparticles: Green Synthesis and Biomedical Application

Review,

NA,

*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,

4457-

SeNPs,

Selenium nanoparticles: a review on synthesis and biomedical applications

Review,

Var,

NA,

Diabetic,

*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,

3192-

SFN,

Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention

in-vitro,

Pca,

PC3

15 μM SFN

Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,

3182-

SFN,

Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells

in-vitro,

AML,

 10 and 30 μM SFN

B1647 cell line

Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,

2166-

SFN,

Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction

in-vitro,

Oral,

in-vivo,

NA,

CSCs↓, selectivity↑, TumCMig↓, TumCI↓,

1498-

SFN,

Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

NCM460

selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,

1502-

SFN,

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

Review,

NA,

HDAC↓, AntiCan↑, DNMTs↓, hTERT/TERT↓, selectivity↑,

1497-

SFN,

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

in-vitro,

Nor,

PrEC

in-vitro,

Pca,

LNCaP

15 µM SFN

in-vitro,

Pca,

PC3

HDAC↓, selectivity↑, TumCCA↑, Apoptosis↑, selectivity↑, H3↑, P21↑, selectivity↑,

1494-

SFN,

doxoR,

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

in-vivo,

BC,

rats

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,

1734-

SFN,

Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia

in-vitro,

Bladder,

RT112

selectivity↑, TumCP↓, Glycolysis↓, Hif1a↓,

1736-

SFN,

Antitumor and antimetastatic effects of dietary sulforaphane in a triple-negative breast cancer models

in-vitro,

BC,

in-vivo,

BC,

TumCG↓, selectivity↓,

3299-

SIL,

Silymarin Effect on Mitophagy Pathway in the Human Colon Cancer HT-29 Cells

in-vitro,

Colon,

HT29

0 (control), 25, 50, and 100 μ, g/ml of Silymarin for 48

tumCV↓, MMP↓, ROS↑, selectivity↑,

3282-

SIL,

Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions

Review,

NA,

hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,

2230-

SK,

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer

in-vitro,

CRC,

HCT116

in-vivo,

NA,

TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,

2185-

SK,

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

in-vitro,

Lung,

LLC1

10 μM

in-vitro,

Melanoma,

B16-BL6

in-vivo,

NA,

mouse

Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, selectivity↑, Warburg↓, TumVol↓, TumW↓,

2227-

SK,

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

in-vitro,

GC,

BGC-823

13.35uM

in-vitro,

GC,

SGC-7901

9.63uM

in-vitro,

Nor,

GES-1

>20 μM

selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,

2226-

SK,

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

in-vitro,

HCC,

HUH7

in-vitro,

HCC,

Bel-7402

selectivity↑, ROS↑, eff↓, Akt↓, RIP1↓, NF-kB↓,

3048-

SK,

Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

4T1

in-vitro,

Nor,

MCF12A

in-vivo,

NA,

tumCV↓, selectivity↑, EMT↓, TumCMig↓, TumCI↓, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, β-catenin/ZEB1↓, GSK‐3β↑,

2009-

SK,

Necroptosis inhibits autophagy by regulating the formation of RIP3/p62/Keap1 complex in shikonin-induced ROS dependent cell death of human bladder cancer

in-vitro,

Bladder,

TumCG↓, selectivity↑, *toxicity∅, Necroptosis↑, ROS↑, p62↑, Keap1↑, *NRF2↑, eff↑,

2008-

SK,

Cisplatin,

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo

in-vitro,

CRC,

HCT116

in-vivo,

NA,

mice

ChemoSen↑, selectivity↑, i-ROS↑, DNAdam↑, MMP↓, TumCCA↑, eff↓, *toxicity↓,

2007-

SK,

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

in-vitro,

lymphoma,

U937

<10uM

in-vitro,

BC,

MCF-7

in-vitro,

BC,

SkBr3

in-vitro,

CRC,

HCT116

in-vitro,

OS,

U2OS

NA,

Nor,

RPE-1

RPE-1-GFP-EB3 cells were treated with 25 μM shikonin

tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,

2010-

SK,

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

in-vitro,

Lung,

H1975

2.6uM

in-vitro,

Lung,

H1650

3.9uM

in-vitro,

Nor,

CCD19

12.2uM

Normal cells, shows <span class="wphighlight">selectivity</span>

EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,

977-

SK,

A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells

in-vitro,

BC,

T47D

SK (1-5uM) for 24 h

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

HMEC

TumCG↓, ERα/ESR1↓, selectivity↑, *toxicity↓,

4742-

SSE,

Antitumor Effects of Selenium

Review,

Var,

Review,

Arthritis,

Review,

Sepsis,

*antiOx↓, *Inflam↓, Risk↓, TumCI↓, TumMeta↓, radioP↑, chemoP↑, Apoptosis↑, ROS↑, DNAdam↑, Dose↑, selectivity↑, *other↓, *BioAv↑, ROS↑, MMP↓, Casp↑, *Imm↑, *Pain↓, Sepsis↓, MMP2↓, MMP9↓, *Half-Life↓,

5078-

SSE,

Rad,

Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer

Trial,

Pca,

33 mg dose level,

15 patients with metastatic cancer treated with selenite (5.5 to 49.5 mg) orally as a single dose 2 hours before each radiation therapy (RT) treatment.

Half-Life↝, OS↑, Pain↓, PSA↓, GSH↓, ROS↑, selectivity↑, TumCG↓, AR↓, Dose↑, ChemoSen↑, RadioS↑,

5074-

SSE,

Application of Sodium Selenite in the Prevention and Treatment of Cancers

Review,

Var,

Imm↑, angioG↑, DNArepair↑, NK cell↑, ROS↑, AntiCan↑, selectivity↑, ER Stress↑, TumAuto↑, necrosis↑, toxicity↝, Dose↑,

5093-

SSE,

Pharmacological mechanisms of the anticancer action of sodium selenite against peritoneal cancer in mice

in-vivo,

Var,

AntiCan↑, eff↑, selectivity↑, ROS↑, Dose↝, Trx↓, GSH↓,

5110-

SSE,

Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells

in-vitro,

AML,

APL NB4

Apoptosis↑, selectivity↑, TumAuto↓, PI3K↓, Akt↓,

5088-

SSE,

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

in-vitro,

BC,

MCF-7

in-vitro,

GBM,

U87MG

in-vitro,

Pca,

PC3

in-vitro,

Cerv,

HeLa

in-vitro,

GBM,

A172

Ferroptosis↑, ROS↑, Iron↑, xCT↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,

5086-

SSE,

Sodium Selenite Induces Superoxide-Mediated Mitochondrial Damage and Subsequent Autophagic Cell Death in Malignant Glioma Cells

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

T98G

in-vitro,

GBM,

A172

TumAuto↑, ROS↑, TumCD↑, tumCV↓, selectivity↑, MMP↓, eff↓, MitoP↑,

1688-

SSE,

Potential Role of Selenium in the Treatment of Cancer and Viral Infections

Review,

Var,

IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,

5327-

TFdiG,

Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells

in-vitro,

Ovarian,

A2780S

23.81 μM

TumCG↓, selectivity↑, TumCCA↑, Apoptosis↑, P53↑, BAX↑, BAD↑, cl‑Casp3↑, p‑Akt↓, MDM2↓, MMP↓, Cyt‑c↑,

5330-

TFdiG,

Cisplatin,

Theaflavin-3,3′-Digallate Enhances the Inhibitory Effect of Cisplatin by Regulating the Copper Transporter 1 and Glutathione in Human Ovarian Cancer Cells

in-vitro,

Ovarian,

A2780S

in-vitro,

Ovarian,

OVCAR-3

selectivity↑, ChemoSen↑, DNAdam↑, GSH↓, CTR1↑,

1935-

TQ,

Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis

Review,

OS,

Apoptosis↑, TumCCA↑, angioG↓, TumMeta↓, ROS↑, P53↑, Twist↓, E-cadherin↑, N-cadherin↓, NF-kB↓, IL8↓, XIAP↓, Bcl-2↓, STAT3↓, MAPK↓, PI3K↓, Akt↓, ERK↓, MMP2↓, MMP9↓, *ROS↓, HO-1↑, selectivity↑, TumCG↓,

1936-

TQ,

Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line

in-vitro,

Ovarian,

CaOV3

6ug/mL

in-vitro,

Nor,

WRL68

selectivity↑, TumCP↓, MMP↓, Bcl-2↓, BAX↑, ROS↑,

2124-

TQ,

Thymoquinone: an emerging natural drug with a wide range of medical applications

Review,

Var,

hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑,

2097-

TQ,

Crude extract of Nigella sativa inhibits proliferation and induces apoptosis in human cervical carcinoma HeLa cells

in-vitro,

Cerv,

HeLa

 IC50 values for 25, 50, 75 and 100 ug/ml were observed after 72, 48, 24 and 24 h

Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8↑, cl‑PARP↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, P53↑, P21↑, TumCP↓, Apoptosis↓, selectivity↑,

2084-

TQ,

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

Review,

Var,

*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,

2093-

TQ,

Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells

in-vitro,

Liver,

HepG2

TQ (125–1000 ug/mL).

in-vitro,

Nor,

TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,

2096-

TQ,

Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines

in-vitro,

Nor,

GP-293

in-vitro,

Kidney,

ACHN

selectivity↑, eff↝,

2106-

TQ,

Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy

Review,

Var,

Apoptosis↑, TumCCA↑, ROS↑, *Catalase↑, *SOD↑, *GR↑, *GSTA1↓, *GPx↑, *H2O2↓, *ROS↓, *lipid-P↓, *HO-1↑, p‑Akt↓, AMPKα↑, NK cell↑, selectivity↑, Dose↝, eff↑, GSH↓, eff↓, P53↑, p‑STAT3↓, PI3K↑, MAPK↑, GSK‐3β↑, ChemoSen↑, RadioS↑, BioAv↓, NRF2↑,

2110-

TQ,

Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells

in-vitro,

HCC,

HepG2

50–250 μg/ml) of NSO

44.6 μg/ml

in-vitro,

BC,

MCF-7

46.2 μg/ml

in-vitro,

Lung,

A549

245 μg/ml

in-vitro,

Nor,

HEK293

1136 μg/ml

indicates <span class="wphighlight">selectivity</span>

P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Review,

CRC,

6-112uM (table 1)

ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

3424-

TQ,

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Review,

Var,

DNMT1↓, HDAC1↓, TumCCA↑, ROS↑, Apoptosis↑, angioG↓, TumMeta↓, selectivity↑, BioAv↓, BioAv↓, HDAC1↓, HDAC4↓, UHRF1↓, selectivity↑, G9a↓,

3422-

TQ,

Thymoquinone, as a Novel Therapeutic Candidate of Cancers

Review,

Var,

selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,

3421-

TQ,

Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer

Analysis,

Nor,

in-vivo,

Nor,

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

HaCaT

HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,

5020-

UA,

Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway

in-vitro,

Ovarian,

 IC50 of 35 µM in cancer cells and IC50 of 75 µM in normal cell lines

tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,

4857-

Uro,

Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study

in-vitro,

ESCC,

KYSE-30

tumCV↓, selectivity↑, TumCCA↑, ROS↑, Bcl-2↓, BAX↑, P21↑, MMP2↓, MMP9↓,

4838-

Uro,

The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention

Review,

Var,

BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,

4854-

Uro,

Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)

Review,

Pca,

AR↓, ROS↓, Apoptosis↑, selectivity↑, Dose↑, MDA↓, SOD↑, GPx↑, ROS↑, Casp3↑, Casp9↑,

1888-

VitB1/Thiamine,

DCA,

High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate

in-vitro,

PC,

SK-N-BE

NA,

PC,

PANC1

p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,

1215-

VitC,

immuno,

Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma

ex-vivo,

HCC,

in-vivo,

HCC,

mice

other↓, *GPx4↑, *GSH↑, GPx4↓, GSH↓, selectivity↑,

1819-

VitC,

VitK3,

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

Review,

Var,

Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,

1836-

VitC,

VitK3,

Chemo,

Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib

in-vitro,

AML,

tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,

3145-

VitC,

Vitamin C inhibits the growth of colorectal cancer cell HCT116 and reverses the glucose‐induced oncogenic effect by downregulating the Warburg effect

in-vitro,

CRC,

HCT116

Warburg↓, TumCG↓, Glycolysis↓, GlucoseCon↓, ATP↓, lactateProd↓, selectivity↑, GLUT1↓, PKM2↓, LDHA↓, mTOR↓,

3109-

VitC,

Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway

in-vitro,

Lung,

H1299

TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,

3104-

VitC,

Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations

*antiOx↑, *ROS↓, *DNAdam↓, ROS↑, TET1↑, CSCs↓, HIF-1↓, BioAv↑, selectivity↑,

3133-

VitC,

Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells

in-vitro,

Ovarian,

*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,

2279-

VitK2,

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways

in-vitro,

Bladder,

T24/HTB-9

0-100uM

in-vitro,

Bladder,

J82

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

L02

in-vivo,

NA,

mice

MMP↓, Cyt‑c↑, Casp3↑, p‑JNK↑, p‑p38↑, ROS↑, eff↓, tumCV↓, selectivity↑, *toxicity↓, TumVol↓,

1821-

VitK3,

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration

in-vitro,

Oral,

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

HaCaT

selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

1820-

VitK3,

Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells

in-vitro,

CRC,

SW480

in-vitro,

CRC,

SW-620

selectivity↑, TumCI↓, TumCMig↓, EMT↓, E-cadherin↑, ZO-1↑, N-cadherin↓, Vim↓, Zeb1↓, MMP2↓, MMP9↓, TOPflash↓, β-catenin/ZEB1↓, p300↓, cycD1/CCND1↓, TumCCA↑,

4890-

ZER,

Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite

in-vitro,

Nor,

RAW264.7

*iNOS↓, *COX2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

4886-

ZER,

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio

in-vitro,

Liver,

HepG2

3.45 ± 0.026 μg/ml.

TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 392

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 3, CD8+↑, 1, Sepsis↓, 1,
Total Targets: 726

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx?, 1, antiOx↓, 2, antiOx↑, 32, mt-antiOx↑, 1, Catalase↑, 9, Copper↓, 1, Fenton↓, 1, GPx↑, 7, GPx1↑, 1, GPx4↑, 1, GSH↓, 1, GSH↑, 14, GSH/GSSG↑, 1, GSR↑, 1, GSSG↓, 1, GSSG∅, 1, GSTA1↓, 1, GSTA1↑, 1, GSTs↑, 2, H2O2↓, 1, H2O2↑, 1, HDL↑, 1, HO-1↑, 7, hyperG↓, 1, Iron↓, 1, lipid-P↓, 5, MDA↓, 6, Nrf1↑, 1, NRF2↑, 12, Prx↑, 1, Prx4∅, 1, ROS?, 1, ROS↓, 37, ROS↑, 4, ROS∅, 16, SAM-e↑, 1, selenoP↑, 2, SOD↑, 12, SOD1↑, 1, SOD2↑, 2, VitC↑, 2, VitE↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 2, ATP↝, 1, mitResp↑, 1, MMP↑, 1, MMP∅, 2, OCR↑, 1,

Core Metabolism/Glycolysis ⓘ

ACLY∅, 1, ALAT↓, 2, AMPK↑, 1, ECAR↓, 1, GlucoseCon↑, 2, Glycolysis↓, 1, Glycolysis↑, 1, NAD↑, 1, NAD↝, 1, NADPH↑, 1, NADPH∅, 1, PPARγ↑, 1, SIRT1↑, 2,

Cell Death ⓘ

Akt↓, 1, Apoptosis↓, 1, Bax:Bcl2↓, 1, Casp3↓, 2, Casp3∅, 1, cl‑Casp8↑, 1, Cyt‑c↓, 2, Cyt‑c∅, 1, HGF/c-Met↑, 1, IAP1↓, 1, iNOS↓, 3, JNK↓, 1, JNK↑, 1, MAPK↓, 1,

Transcription & Epigenetics ⓘ

other↓, 1, other↝, 5,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, HSP27↓, 1, p‑PERK↑, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 3, DNAdam↑, 1, GADD45A↑, 1, P53↓, 1,

Cell Cycle & Senescence ⓘ

P21↓, 1,

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1, EP2↓, 1, ERK↓, 1, ERK↑, 1, p‑ERK↑, 1, FGF↑, 1, GSK‐3β↓, 1, mTOR↓, 3, PTEN↑, 1,

Migration ⓘ

AntiAg↑, 1, Ca+2↓, 2, Ca+2↑, 1, Ca+2↝, 2, Ca+2∅, 1, i-Ca+2↓, 1, MMP13↓, 1, MMPs↑, 1, PDGF↑, 1, PKCδ?, 1, serineP↓, 1, TGF-β↑, 1, TIMP1↓, 1, α-tubulin↓, 1, β-Endo↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, angioG↑, 1, Hif1a↑, 1, NO↓, 2, VEGF↑, 2,

Barriers & Transport ⓘ

BBB↑, 4, GLUT1↓, 1, SVCT-2↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 6, CRP↓, 2, IFN-γ↓, 1, IL1↑, 1, IL10↓, 1, IL17↓, 1, IL1β↓, 5, IL6↓, 4, IL8↓, 1, Imm↑, 2, Inflam↓, 26, MCP1↓, 1, NF-kB↓, 7, PGE2↓, 1, TNF-α↓, 8, TNF-α↑, 1, VitD↑, 1,

Synaptic & Neurotransmission ⓘ

5HT↓, 1, AChE↑, 1, BDNF↑, 2, tau↓, 2,

Protein Aggregation ⓘ

Aβ↓, 3,

Hormonal & Nuclear Receptors ⓘ

GR↑, 2, testos↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 14, BioAv↑, 12, BioAv↝, 2, BioEnh↑, 1, Dose↑, 1, Dose↝, 6, eff↑, 14, eff↝, 1, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 3, Half-Life∅, 2, P450↓, 1, selectivity↑, 8,

Clinical Biomarkers ⓘ

ALAT↓, 2, ALP↓, 1, AST↓, 2, BG↓, 1, BMD↑, 2, BMPs↑, 1, BP↓, 1, Calcium↑, 1, creat↓, 1, CRP↓, 2, GutMicro↑, 1, HbA1c↓, 1, hs-CRP↓, 1, IL6↓, 4, Mag↑, 1, VitD↑, 1,

Functional Outcomes ⓘ

AntiAge↑, 1, AntiCan↓, 1, AntiCan↑, 2, AntiDiabetic↑, 1, AntiTum↑, 1, cardioP↑, 7, CardioT↓, 1, chemoP↑, 7, chemoPv↑, 2, ChemoSideEff↓, 1, cognitive↑, 3, hepatoP↑, 3, memory↑, 4, neuroP↑, 9, OS↑, 1, Pain↓, 2, radioP↑, 4, RenoP↑, 2, Risk↓, 2, toxicity?, 1, toxicity↓, 40, toxicity↝, 8, toxicity∅, 19,

Infection & Microbiome ⓘ

AntiViral↑, 1, Bacteria↓, 9, Inf↓, 1,
Total Targets: 199

Scientific Paper Hit Count for: selectivity, selectivity

34 Silver-NanoParticles
26 Magnetic Fields
17 Piperlongumine
14 Selenium NanoParticles
13 Thymoquinone
11 Radiotherapy/Radiation
10 Chemotherapy
10 salinomycin
10 Phenethyl isothiocyanate
10 Shikonin
9 Vitamin C (Ascorbic Acid)
9 Dichloroacetate
9 Sulforaphane (mainly Broccoli)
8 doxorubicin
8 Betulinic acid
8 Copper and Cu NanoParticles
8 Honokiol
8 Magnetic Field Rotating
8 Propolis -bee glue
8 Quercetin
8 Selenite (Sodium)
7 Artemisinin
7 Berberine
6 Apigenin (mainly Parsley)
6 Baicalein
6 Capsaicin
6 chitosan
6 EGCG (Epigallocatechin Gallate)
6 Fisetin
6 Hydrogen Gas
5 3-bromopyruvate
5 Rosmarinic acid
5 Ashwagandha(Withaferin A)
5 Melatonin
5 Curcumin
5 Selenium
5 HydroxyTyrosol
4 Alpha-Lipoic-Acid
4 Phenylbutyrate
4 Boron
4 diet FMD Fasting Mimicking Diet
4 Ellagic acid
4 Lycopene
4 Magnolol
4 Cisplatin
4 Parthenolide
4 VitK3,menadione
3 Fenbendazole
3 Allicin (mainly Garlic)
3 Metformin
3 Astaxanthin
3 Atorvastatin
3 Chrysin
3 Citric Acid
3 diet Methionine-Restricted Diet
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Urolithin
2 Dipyridamole
2 Gold NanoParticles
2 Caffeic acid
2 Coenzyme Q10
2 Hydroxycinnamic-acid
2 Date Fruit Extract
2 Oxygen, Hyperbaric
2 Disulfiram
2 Gambogic Acid
2 Graviola
2 Luteolin
2 SonoDynamic Therapy UltraSound
2 Plumbagin
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Boswellia (frankincense)
1 Carnosic acid
1 urea
1 chemodynamic therapy
1 diet Ketogenic
1 PXD, phenoxodiol
1 Emodin
1 Juglone
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Nimbolide
1 Oleuropein
1 Hyperthermia
1 Propyl gallate
1 temozolomide
1 borneol
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 Ursolic acid
1 Vitamin B1/Thiamine
1 immunotherapy
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , selectivity

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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